The influence of dietary supplementation with cranberry tablets on the urinary risk factors for nephrolithiasis

Redmond, Elaine J.; Murphy, Ciaran; Leonard, James V.; Faulds, K; Abdelfadil, S; Crowley, V E; Lynch, Thomas; Manecksha, Rustom P.

doi:10.1007/s00345-018-2344-1

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…31 Importantly, cranberry tablets may alter urinary oxalate and uric acid excretion, so patients with a history of urolithiasis should be counselled about this risk before choosing cranberry as a preventative approach. 32 Until now, the evidence to support a role of cranberries for UTI prevention is inconclusive. Recent evidence, however, suggests that some of the conflicting evidence regarding cranberry efficacy in UTI prevention may come from differences in cranberry formulations and products; varying amounts of bioactive PACs within each product may underlie differing efficacies in UTI prevention.…”

Section: Cranberriesmentioning

confidence: 99%

Recurrent Urinary Tract Infection in Women from a Urologist’s Perspective

Ramart

Ackerman²

2023

Siriraj Med J

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Urinary tract infection (UTI) referred to microbial invasion of the urinary tract system, typically due to bacteria. UTI is more common in women than men, which is thought to be due to differences in lower urinary tract anatomy. Making a diagnosis of UTI begins with the presence of clinical symptoms consistent with either pyelonephritis and cystitis. When pyelonephritis symptoms are present, it is usually associated with bacterial infection, while the symptoms of clinical cystitis may or may not be caused by infection. As both urologic and non-urologic conditions can produce the clinical symptoms of cystitis, diagnosis of UTI requires both pyuria and bacteriuria on urine examination. Complicated UTI is when the infection is associated with either host or bacterial factors that increase the chance of reinfection and decrease treatment efficacy, such as altered organism virulence, immunocompromise, or urinary tract abnormalities. The urologist’s primary role in UTI management is to evaluate for such urinary tract abnormalities and, if needed, resolve those conditions to prevent recurrent infection. This review will describe the urologists’ evaluation and management of complicated and recurrent UTI and inform physician about the urinary tract abnormalities that can predispose to recurrent UTI.

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Section: Cranberriesmentioning

confidence: 99%

Recurrent Urinary Tract Infection in Women from a Urologist’s Perspective

Ramart

Ackerman²

2023

Siriraj Med J

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“…Thus, warfarin can interfere with cranberry polyphenols and can cause severe bleeding. In addition, cranberry may stimulate increased vitamin B 12 absorption in patients being treated with proton pump inhibitors, stimulating the rapid metabolism of alkaline drugs (e.g., antidepressants or opioids) and reducing their therapeutic efficacy (Redmond et al, 2019).…”

Section: Therapeutic Perspectives and Clinical Gapsmentioning

confidence: 99%

Therapeutic potential of cranberry for kidney health and diseases

Amin

Thalluri

Docea

et al. 2022

eFood

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A higher risk of cardiovascular mortality in persons with chronic renal failure (CRF) is linked to inflammation, oxidative stress, cellular aging, and gut dysbiosis, to name a few contributing factors. According to a growing body of evidence, some dietary choices may reduce the severity of certain adverse effects. Specialized databases such as PubMed/Medline, Embase, Google Scholar, and UpToDate were searched to find published studies that focus on the pharmacological effects and mechanisms of cranberries' bioactive compounds on CRF and human health. Cranberry supplementation has been demonstrated in clinical research to offer health advantages for humans, such as reducing urinary tract infections. Recently, it has been reported that cranberry polyphenols possess anti-inflammatory and antioxidant effects and are also known to have the capacity to affect gut flora. Scientific studies on the beneficial pharmacological effects of cranberries on human health may provide an understanding of traditional cranberry therapy in chronic kidney disease and other chronic conditions. However, translational studies are needed to determine the exact dose that can be administered to humans as well as the validation of nutritional supplements that contain cranberry extract.

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“…In this context, neurogenic bowel dysfunction (NBD), comorbidity, and polypharmacy and potential nutraceutical-drug interactions should be monitored [33], in particular in aged patients with SCI [42]. With ageing, individuals with SCI have an increased risk of renal stones [42], and the effect of CB on nephrolithiasis is controversial [43,44].…”

Section: Completeness Quality and Applicability Of Evidencementioning

confidence: 99%

Cranberry for Bacteriuria in Individuals with Spinal Cord Injury: A Systematic Review and Meta-Analysis

Raguzzini

Toti

Sciarra³

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Urinary tract infection (UTI) is common in individuals with spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction (NLUTD) and in veterans with SCI who use antibiotics improperly for asymptomatic bacteriuria. Cranberry (CB) has been suggested for UTI prevention. Methods. We performed a systematic search up to May 2020 in the following databases: AccessMedicine, BioMed Central, CINAHL, Cochrane Library, ProQuest, and PubMed. Quality assessment was performed using a specifically designed quality score. Risk ratio was calculated with both random effect model analysis (DerSimonian-Laird method) and quality effect model analysis (Doi Thalib method). Results. Six studies on bacteriuria and SCI were reviewed. From the four studies available for meta-analysis, two of which with individuals taking both CB and control, 477 data from 415 participants were analysed (241 CB and 236 control). No significant differences were detected with meta-analysis. However, bias, limitations, and incompleteness were observed in the reviewed studies. Conclusion. Although further studies are needed, we suggest an accurate monitoring of diet and fluid intake, the evaluation of risk for potential food or nutraceutical interactions with drugs, and the inclusion of inflammatory markers among the outcomes in addition to UTI.

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The influence of dietary supplementation with cranberry tablets on the urinary risk factors for nephrolithiasis

Abstract: Dietary supplementation with cranberry increases urinary oxalate excretion and should be avoided in patients at risk of urolithiasis.

Cited by 7 publications

References 20 publications

Recurrent Urinary Tract Infection in Women from a Urologist’s Perspective

Recurrent Urinary Tract Infection in Women from a Urologist’s Perspective

Therapeutic potential of cranberry for kidney health and diseases

Cranberry for Bacteriuria in Individuals with Spinal Cord Injury: A Systematic Review and Meta-Analysis

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