The influence of dietary selenium as selenium yeast or sodium selenite on the concentration of selenium in the milk of Suckler cows and on the selenium status of their calves.

Pehrson, B.; Ortman, K.; Madjid, N; Trafikowska, U.

doi:10.2527/1999.77123371x

Cited by 90 publications

(44 citation statements)

References 17 publications

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“…Plasmatic levels of selenium in dams and newborn calves as well as selenium levels in colostrum and milk were higher in the group supplemented with Se-enriched yeast. Pehrson et al (1999) made similar findings in Hereford cows. Ortman and Pehrson (1999) compared the effect of selenate, selenite and selenium yeast in dairy cows.…”

Section: Discussionsupporting

confidence: 70%

Effect of a long-term peroral supplementation with sodium selenite and selenium lactate-protein complex on selenium status in goats and their kids

Mišurová¹,

Pavlata²,

Pechová³

et al. 2009

Vet. Med.

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AbstrAct:The aim of this study was to evaluate the effect of a long-term peroral selenium supplementation in the form of sodium selenite and selenium lactate-protein complex by comparing selenium concentrations and glutathione peroxidase activity in blood of goats and their kids as well as comparing selenium concentrations in goat colostrums. For the study, a total of 27 clinically healthy pregnant white shorthair goats were used. They were divided to three groups, i.e., the control group (C) without any selenium supplementation, sodium selenite group (E1) and selenium lactate-protein complex group (E2). For four months, experimental goats received 0.43 mg of selenium per animal per day in diet; goats from the control group were given 0.15 mg of selenium per animal per day. At the beginning of the experiment, goats of all groups showed an average selenium concentration of 96 μg/l in whole blood. On the parturition day, samples of first colostrum from goats and heparinized blood from goats and kids were taken. In the control group (C), average blood selenium concentrations of 111.4 ± 33.5 μg/l were observed on the parturition day. In both experimental groups, selenium concentrations were significantly higher (P < 0.05). Average selenium concentration in the sodium selenite group (E1) was 177.2 ± 34.8 μg/l and in the group supplemented with selenium lactate-protein complex (E2) 159.0 ± 28.5 μg/l. Average glutathione peroxidase (GSH-Px) activity in blood of control goats (C) was 581.9 ± 99.2 μkat/l, in group E1 1 154.6 ± 156.2 μkat/l and in group E2 1 011.6 ± 153.6 μkat/l. GSHPx activity in experimental groups was significantly higher (P < 0.05) as compared with the control group. Average selenium concentrations in colostrum was in the control group 40.1 ± 12.8 μg/l, in E1 99.0 ± 29.9 μg/l and in group E2 79.0 ± 17.7 μg/l. Colostral selenium concentrations in experimental groups were significantly higher (P < 0.05) as compared with the control group. No significant difference in the monitored parameters was found between experimental groups. In kids of control mothers (kC), average selenium concentrations in blood on the parturition day were 62.4 ± 22.9 μg/l; kids of mothers supplemented with sodium selenite (kE1) showed average selenium levels of 100.0 ± 31.2 μg/l, and the average selenium concentration in kids of mothers receiving lactate-protein complex was 83.4 ± 20.1 μg/l (kE2). Average GSH-Px activity in control kids (kC) was 402.1 ± 153.9 μkat/l. Kids from kE1 showed average activity of GSH-Px 806.1 ± 254.9 μkat/l and kids from group kE2 529.9 ± 119.8 μkat/l. Statistically significant difference (P < 0.05) was found only between kC and kE1 which showed significantly higher selenium concentration and GSH-Px activity. The results of this study confirm that both forms of selenium administered in experimental groups (i.e., sodium selenite and selenium lactate-protein complex) had similar biological effect in goats. However, results obtained in kids indicate a better effect of supplementation with sodium selenite.

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Section: Discussionsupporting

confidence: 70%

Effect of a long-term peroral supplementation with sodium selenite and selenium lactate-protein complex on selenium status in goats and their kids

Mišurová¹,

Pavlata²,

Pechová³

et al. 2009

Vet. Med.

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“…l -1 . The corresponding values given by Pehrson et al (1999) were 1 869 ± 230 µkat . l -1 and 112 ± 11 µg .…”

Section: Resultsmentioning

confidence: 99%

Direct and Indirect Assessment of Selenium Status in Cattle - A Comparison

Pavlata¹,

Pechová²,

Illek³

2000

Acta Vet. Brno

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Selenium concentration and activity of glutathione peroxidase (GSH-Px) as direct and indirect indicators of selenium status were determined in whole blood samples collected from 326 cattle in 30 herds kept in various regions of the Czech Republic. The GSH-Px activity in the samples was measured by the UV method, using the set supplied by Randox. Selenium in the sample was measured using the hydride technique AAS. The two variables showed a close and significant correlation (r = 0.90; p < 0.01). The regression line, defined by the equation y = 6.44x + 21.4, allowed us to determine the GSH-Px activity of 665.4 µkat . l -1 as equivalent to selenium concentration in whole blood 100 µg . l -1 . Mean selenium concentration and mean GSH-Px activity found in whole blood samples were 78.25 ± 46.67 µg . l -1 and 525.51 ± 335.56 µkat . l -1 , respectively. Insufficient or marginal supply of selenium was diagnosed in 64% of the animals in terms of selenium concentration, in 63% of the animals in terms of GSH-Px activity and in 55% of the animals with selenium concentrations <100 µg . l -1 and GSH-Px activity < 665.4 µkat . l -1 . In this study, close dependence of GSH-Px activity and selenium concentration in the blood of cattle was found. Activity values of GSH-Px were determined for the use in diagnosis of insufficient selenium in cattle in the Czech Republic.

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“…However, feeding organic selenium to cows results in effective and rapid incorporation into milk proteins (12)(13)(14). Such a source might be advantageous.…”

Section: Introductionmentioning

confidence: 99%

Suppression of Colorectal Oncogenesis by Selenium-Enriched Milk Proteins: Apoptosis and K-ras Mutations

et al. 2008

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The chemical form and bioavailability of dietary selenium may influence its protectiveness against colorectal cancer. Selenium is readily incorporated into milk proteins by feeding cows with selenized-yeast. This study examined whether a dairy source of organic selenium (as milk proteins) is more effective than a yeast source at inhibiting oncogenesis in carcinogentreated mice and whether it regulates the homeostatic response to carcinogen-induced DNA damage. Dietary interventions are as follows: selenium-enriched milk protein isolate (Tatura-Bio Se; 0.5 or 1 ppm selenium) or milk protein control and selenized-yeast (Sel-Plex; 1 or 4 ppm selenium) with casein or casein alone as control. After 4 weeks on diet, mice received a single azoxymethane (10 mg/kg) injection to induce mutations and were killed 6 hours later. Measures were as follows: plasma selenium, cell proliferation, and acute apoptotic response to azoxymethane (AARGC). Separate groups of mice on the same diets were given 4 weekly azoxymethane (15 mg/kg) injections to induce oncogenesis. Mice were killed 6 or 30 weeks after the last azoxymethane injection. Measures were as follows: aberrant crypt foci (ACF), cancers, and K-ras mutations. Dairy-selenium at 1 ppm significantly suppressed ACF and cancers, whereas yeastselenium at an equivalent selenium intake had no effect. Dairy-selenium significantly increased plasma selenium levels and AARGC, and reduced cell proliferation and frequency of Kras mutations in ACF relative to an equivalent dose of selenium from yeast. Selenium-enriched milk protein isolate is superior to selenized-yeast in terms of its bioavailability and capacity to suppress oncogenesis. Suppression may be a consequence of enhanced apoptotic deletion of azoxymethane-induced DNA lesions and the subsequent reduction in frequency of K-ras mutations. [Cancer Res 2008;68(12):4936-44]

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The influence of dietary selenium as selenium yeast or sodium selenite on the concentration of selenium in the milk of Suckler cows and on the selenium status of their calves.

Cited by 90 publications

References 17 publications

Effect of a long-term peroral supplementation with sodium selenite and selenium lactate-protein complex on selenium status in goats and their kids

Effect of a long-term peroral supplementation with sodium selenite and selenium lactate-protein complex on selenium status in goats and their kids

Direct and Indirect Assessment of Selenium Status in Cattle - A Comparison

Suppression of Colorectal Oncogenesis by Selenium-Enriched Milk Proteins: Apoptosis and K-ras Mutations

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