The influence of dietary calcium and phosphorus upon tooth formation

Gaunt, W. E.; Irving, J. T.

doi:10.1113/jphysiol.1940.sp003875

Cited by 47 publications

(6 citation statements)

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“…Young albino rats fed a diet low in calcium and virtually vitamin D free show mineralization disorders in dentin, and the most rapid and severe effects are produced when the calcium/phorphorous ratio is low (Gaunt & Irving 1940, Ferguson & Hartles 1966, Harrand et al 1966. After 2 weeks on the diet R 25, disturbances in dentinogenesis and lowered serum calcium values were obtained in our animals.…”

Section: Discussionsupporting

confidence: 48%

Odontoblast metabolism in rats deficient in vitamin D and calcium I

Engström

Linde

Magnusson

1977

J Oral Pathology Medicine

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Different rat diets, deficient in calcium and/or vitamin D, were tested for varying experimetital periods to obtain changes in serum calcium values, body weight gain and odontoblast-predentine morphology. One diet, R 25, used during a 14-day period, was found to induce lowered serum calcium values and an increased predentin width in incisor teeth. Rats fed this diet demonstrated an increase in alkaline phosphatase and ATP-splitting enzyme activity in dentinogenically active incisor odontoblast,s. No other metabolic changes in these cells were demonstrated by the histochemical methods employed.

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Section: Discussionsupporting

confidence: 48%

Odontoblast metabolism in rats deficient in vitamin D and calcium I

Engström

Linde

Magnusson

1977

J Oral Pathology Medicine

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“…Adequate nutritional quantities of calcium and phosphorus are important for dental mineralization. A dietary ratio of 4–5 was necessary for normal bone and dentin calcification in rats that were observed from 23 to 70 days of age [ 272 , 273 ]. Calcium and phosphorus deficiency disturb calcification of the growing dentin and alveolar bone in rats [ 272 , 274 ], although enamel formation and calcification are not impaired [ 272 ].…”

Section: Importance Of Dietary Phosphorus For Teeth (Or Dental Heamentioning

confidence: 99%

Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Serna

Bergwitz

2020

Nutrients

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Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main source of dietary phosphorus. Reduced bioavailability of Pi or excessive losses in the urine causes rickets and osteomalacia. While critical for health in normal amounts, dietary phosphorus is plentiful in the Western diet and is often added to foods as a preservative. This abundance of phosphorus may reduce longevity due to metabolic changes and tissue calcifications. In this review, we examine how dietary phosphorus is absorbed in the gut, current knowledge about Pi sensing, and endocrine regulation of Pi levels. Moreover, we also examine the roles of Pi in different tissues, the consequences of low and high dietary phosphorus in these tissues, and the implications for healthy aging.

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“…A common method of inducing changes of the calcium metabolism in the rat is to use diets with different contents and ratios of calcium and phosphate (15,16). It is known that bone is more affected when phosphate is low, while dental hard tissues are more affected by a low-calcium diet (7,15,19). The diet R25, used in this experiment, is low in calcium and also lacks vitamin D. It has been shown that vitamin D deficiency is necessary to induce a hypocalcemic state in rats fed this low-calcium diet (16).…”

Section: Discussionmentioning

confidence: 99%

“…The rat is thus an excellent experimental animal for research in dental development. By feeding the rat a special low-calcium diet (15,16), hypocalcemia can be induced.…”

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Effect of hypocalcemic state on enamel formation in rat maxillary incisors

Ranggård¹,

Norén²

1994

European J Oral Sciences

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Effect of hypocalcemic state on enamel formation in rat maxillary incisorsRanggdrd L, Noren JG: Effect of hypocalcentic state on enatnel fortnation in rat tnaxillaty ittcisors. Seattd J Detn Res 1994; 102: 249-53. © Munksgaard, 1994. Several authors have proposed that hypocalcemia can interfere with amelogenesis, resulting in enamel aberrations. Therefore, the purpose of this investigation was to study the effects of a diet-induced hypocalcemic state in young rats on enamel formation of the maxillary incisors. The experimental rats were fed a special diet, free from vitamin D and very low in calcium. The control rats were fed a normal diet. The experimental period was 3 wk. After termination, the blood analysis showed that the experimental rats had developed hypocalcemia with very low values of both total and ionized blood calcium. The experimental rats were smaller than their controls after 3 wk, with smaller skulls and teeth. At the light microscope level, the enamel and the ameloblasts did not seem to be affected, except in one rat, the smallest, which showed enamel hypoplasias in both maxillary incisors and a delayed increase of the mineral content during the maturation stage process. It is concluded that the hypocalcemic state induced did not greatly affect enamel formation. However, occasional enamel aberrations may occur.

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The influence of dietary calcium and phosphorus upon tooth formation

Cited by 47 publications

References 2 publications

Odontoblast metabolism in rats deficient in vitamin D and calcium I

Odontoblast metabolism in rats deficient in vitamin D and calcium I

Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Effect of hypocalcemic state on enamel formation in rat maxillary incisors

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