Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Serna, J.; Bergwitz, Clemens

doi:10.3390/nu12103001

Cited by 82 publications

(60 citation statements)

References 360 publications

(514 reference statements)

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“…It has a significant impact on how the body utilises carbohydrates and lipids. Protein is also required to grow, maintain, and repair cells and tissues in the body [41]. The zinc and phosphorus content being higher in F. carica than F. carica and F. thonningii in this study suggests F. carica is a better source of those minerals mentioned above.…”

Section: Discussionmentioning

confidence: 53%

Proximate and Mineral Composition, Phytochemical Analysis, and Antioxidant Activity of Fig Trees (Ficus spp.) Leaf Powder

Osowe

Olowu²,

Adu

et al. 2021

AJBGMB

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Aim: This study aims to analyse and characterise the leaf powder of Ficus carica, Ficus exasperata, and Ficus thonningii. Methodology: Ficus carica, Ficus exasperata, and Ficus thonningii leaf powder were analysed quantitatively for proximate, phytochemicals, minerals, and antioxidant activity. Results: The ash, crude protein, and nitrogen free extract concentration were significantly (P<0.05) higher in Ficus carica leaf powder than the rest Ficus species under study. However, the crude fiber and crude fat concentrations were higher (P<0.05) in Ficus thonningii and Ficus exasperata leaf powder, respectively. The concentration of tannins, flavonoids, phenols, and saponins was higher (P<0.05) in Ficus exasperata than other Ficus species under study. However, the concentration of the alkaloids was higher (P<0.05) in Ficus carica leaf powder than Ficus exasperata and Ficus thonningii leaf powder. The Zn and P were higher (P<0.05) in Ficus carica than the rest F. species under study. The Fe contents of F. carica and F. exasperata leaf powders were higher (P<0.05) than F. thonningii leaf powder. The Ca contents of F. carica leaf powder and F. thonningii leaf powder were higher (P>0.05) than F. exasperata leaf powder. The 2, 2-diphenyl-1-picryl-hydrazyl-hydrate value was higher (P<0.05) in Fiscus exasperata leaf powder than F. carica and F. thonningii. However, the value of vitamin c was higher (P<0.05) in Ficus carica, compared to the rest F. species. Conclusion: This study reveals that the leaf powder of F. carica, F. exasperata, and F. thonningii contains a significant number of minerals and phytochemicals with high antioxidant activity and could be employed as a natural feed supplement in animal nutrition.

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Section: Discussionmentioning

confidence: 53%

Proximate and Mineral Composition, Phytochemical Analysis, and Antioxidant Activity of Fig Trees (Ficus spp.) Leaf Powder

Osowe

Olowu²,

Adu

et al. 2021

AJBGMB

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“…In addition, it is essential to ensure iron intake since it is a key component in DNA and RNA synthesis [12,78]. This element is also involved in several metabolic processes, such as energy transport, and as a structural molecule in the formation of bones and membranes [79,80].…”

Section: Discussionmentioning

confidence: 99%

Portuguese Kelps: Feedstock Assessment for the Food Industry

et al. 2021

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Seaweeds have been incorporated in the daily diet of several human cultures since ancient times, due to their nutritional characteristics and healthy properties. The brown seaweeds Undaria pinnatifida, Saccharina latissima, Sacchoriza polyschides, and Laminaria ochroleuca were collected in the Viana do Castelo (Portugal) bay to assess their proximate composition analysis. As a result, the algal biomass was dried, and its moisture and ash content were determined. The dried biomass was then analyzed for total nitrogen/total protein (using the Kjeldahl method), total fiber content (through fiber analyzer digestion), total lipids (in a Soxhlet apparatus), and fatty acid characterization (by gas chromatography-mass spectrometry). Apart from phosphorus, which was analyzed by spectrophotometry, the ashes were employed for mineral and trace element characterization via dry mineralization and quantified using flame atomic absorption spectrometry. Moreover, the total phenolic content was assessed spectrophotometrically by the Folin-Ciocalteu method in the algal aqueous extracts. Analyses showed that their protein concentrations ranged from 12 to 24% dry weight (DW), while lipid concentrations varied between 0.51% and 1.52% DW. Regarding the carbohydrate concentration in these seaweeds, a concentration between 48% and 60% DW was observed. The S. polyschides had the highest overall total phenolic content (6.19 × 10−3 g GAE/100 g of dried algae), while L. ochroleuca had the lowest amount (3.72 × 10−3 g GAE/100 g of dried algae). U. pinnatifida had the highest total fatty acid content (35.13 mg/g DW), whereas S. latissima presented the lowest value (22.59 mg/g DW). Significant concentrations of highly unsaturated fatty acids (HUFA) were observed in both seaweeds, with U. pinnatifida having the highest value (10.20 mg/g DW) and S. latissima the lowest content (4.81 mg/g DW). It is also highlighted that these seaweeds have a nutritional relevance as a source of essential nutrients, including nitrogen, potassium, sodium, calcium, magnesium, and iron.

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“…Serum phosphate concentration varies with age, with the highest concentration found in infants (1.50-2.65 mM Pi), who require more of the mineral for bone growth and soft tissue development. In adulthood, Pi concentrations are low (0.8-1.5 mM Pi), considering that most phosphate is present in bone and teeth compared to other tissues [18,19].…”

Section: Pi-induced Ros Production Promotes Osteoblast Apoptosismentioning

confidence: 99%

“…In bone, phosphate is primarily complexed with calcium in hydroxyapatite crystals; the remaining phosphate appears as amorphous calcium phosphate [18,19]. Since Ca 2+ and Pi are released from the bone apatite lattice during the resorption process, Ca 2+ may influence Pi-mediated bone cell apoptosis.…”

Section: Osteoblast-like Cells (Human Bone)mentioning

confidence: 99%

Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development

Lacerda-Abreu

Meyer‐Fernandes

2021

IJMS

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Inorganic phosphate (Pi) is an essential nutrient for living organisms and is maintained in equilibrium in the range of 0.8–1.4 mM Pi. Pi is a source of organic constituents for DNA, RNA, and phospholipids and is essential for ATP formation mainly through energy metabolism or cellular signalling modulators. In mitochondria isolated from the brain, liver, and heart, Pi has been shown to induce mitochondrial reactive oxygen species (ROS) release. Therefore, the purpose of this review article was to gather relevant experimental records of the production of Pi-induced reactive species, mainly ROS, to examine their essential roles in physiological processes, such as the development of bone and cartilage and the development of diseases, such as cardiovascular disease, diabetes, muscle atrophy, and male reproductive system impairment. Interestingly, in the presence of different antioxidants or inhibitors of cytoplasmic and mitochondrial Pi transporters, Pi-induced ROS production can be reversed and may be a possible pharmacological target.

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Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Cited by 82 publications

References 360 publications

Proximate and Mineral Composition, Phytochemical Analysis, and Antioxidant Activity of Fig Trees (Ficus spp.) Leaf Powder

Proximate and Mineral Composition, Phytochemical Analysis, and Antioxidant Activity of Fig Trees (Ficus spp.) Leaf Powder

Portuguese Kelps: Feedstock Assessment for the Food Industry

Extracellular Inorganic Phosphate-Induced Release of Reactive Oxygen Species: Roles in Physiological Processes and Disease Development

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