The Influence of Cyclosporin A on Mechanical Retention of Dental Implants Previously Integrated to the Bone: A Study in Rabbits

Sakakura, Celso Eduardo; Margonar, Rogério; Sartori, Rafael; Morais, Juliana Aparecida Najarro Dearo de; Marcantônio, Élcio

doi:10.1902/jop.2006.050290

Cited by 22 publications

(33 citation statements)

References 18 publications

(45 reference statements)

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“…CsA administration does not prevent bone formation and mineralization, but the osteoid maturation and mineralization occur more slowly and a lesser extent. These data close resemble observations made by previous studies (Duarte et al, ; El Hadary et al, ; Sakakura et al, ) that showed impairment of bone healing in animals under CsA therapy started before the implant placement. These findings confirmed the hypothesis that already healed bone around titanium implants might be affected by CsA administration.…”

Section: Discussionsupporting

confidence: 91%

“…Experimental implant surgery was performed as previously described (Sakakura et al, ). Briefly, general anesthesia by an intramuscular injection of a combination of 50‐mg/kg ketamine hydrochloride (Francotar, Virbac of Brazil, Roseira, SP, Brazil) and 10‐mg/kg xylazine hydrochloride (Rompun, Bayer Animal Health, Sao Paulo, SP, Brazil) were accomplished.…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, we and others have examined the effects of CsA on bone healing around dental implants (Duarte et al, ; El Hadary, Yassin, Mekhemer, Holmes, & Grootveld, ; Sakakura, Marcantonio, Wenzel, & Scaf, ; Sakakura, Margonar, Sartori, Morais, & Marcantonio, ; Sakakura et al, ). These studies demonstrated that the short or long‐term CsA administration previous to implant placement lead to decreased bone‐to‐implant contact, decreased bone area around the implant threads (BAFO), and poor quality of the bone resulting in lowest torque values for implant removal (Duarte et al, ; El Hadary et al, ; Sakakura et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of the long-term administration of Cyclosporine A on bone healing around osseointegrated titanium implants: A histomorphometric study in the rabbit tibia

Molon

Sakakura²,

Faeda

et al. 2017

Microsc Res Tech

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The aim of this study was to investigate the effect of cyclosporine A (CsA) therapy on bone healing around osseointegrated implants in the rabbit by means of descriptive histologic and histomorphometric analyses. Eighteen rabbits received one implant each in the right tibia proximal metaphysis. After the bone-healing period of 3 months, 6 randomly selected animals were sacrificed (Group CTL-12) before the immunosuppression therapy initiation to obtain a standard of implant integration. Another six randomly selected animals were submitted to a daily subcutaneous (sc) injection of 10 mg/kg CsA (Group CsA) whereas the six remaining animals received daily sc injections of saline solution (Group CTL-24). Groups CTL-24 and CsA were sacrificed after another 12 weeks. Bone-to-implant contact (BIC), and bone area fraction occupancy (BAFO) within the implant threads were measured. Bone density (BD) and descriptive histological analyses were also accomplished. Rabbits under CsA therapy presented statistically lower percentage of BIC (33.28 ± 6.19) compared to the animals of CLT-24 (55.6 ± 17.73). No differences were found between CsA and CTL-12 (38.7 ± 7.87). Significant decreased percentage of BAFO between the implant threads in the CsA (48.43 ± 9.48) group compared to the CTL-24 (72.26 ± 11.72) was observed. No differences were found between CsA and CTL-12 (61.99 ± 13.94) groups. BD analysis showed significant lower BD in the CsA (48.56 ± 9.32) group compared to the CTL-12 (68.74 ± 10.89) and CTL-24 (77.96 ± 4.96) groups. Collectively, our findings demonstrated that CsA therapy negatively affect the bone healing around osseointegrated implants due to the significant lower values for BIC, BAFO, and BD.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of the long-term administration of Cyclosporine A on bone healing around osseointegrated titanium implants: A histomorphometric study in the rabbit tibia

Molon

Sakakura²,

Faeda

et al. 2017

Microsc Res Tech

Self Cite

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“…, , Sakakura et al. , , ). All of them were performed in small animal models and, in general, were well reported (Table E).…”

Section: Resultsmentioning

confidence: 99%

Systematic review of pre‐clinical models assessing implant integration in locally compromised sites and/or systemically compromised animals

Thoma

Martín

Mühlemann

et al. 2012

J Clinic Periodontology

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Objective: The aim was to systematically search the dental literature for pre-clinical models assessing implant integration in locally compromised sites (part 1) and systemically compromised animals (part 2), and to evaluate the quality of reporting of included publications. Methods: A Medline search was performed, complimented by additional hand searching. The quality of reporting of the included publications was evaluated using the 20 items of the ARRIVE (Animals in Research In Vivo Experiments) guidelines. Results: One-hundred and seventy-six (part 1; mean ARRIVE score = 15.6 ± 2.4) and 104 (part 2; 16.2 ± 1.9) studies met the inclusion criteria. The overall mean score for all included studies amounted to 15.8 ± 2.2. Housing (38.3%), allocation of animals (37.9%), numbers analysed (50%) and adverse events (51.4%) of the ARRIVE guidelines were the least reported. Statistically significant differences in mean ARRIVE scores were found depending on the publication date (p < 0.05), with the highest score of 16.7 ± 1.6 for studies published within the last 2 years. Conclusions: A large number of studies met the inclusion criteria. The ARRIVE scores revealed heterogeneity and missing information for selected items in more than 50% of the publications. The quality of reporting shifted towards betterreported pre-clinical trials within recent years.

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“…The bone density calculations were performed based on the average gray levels of the evaluated ROIs, which were divided by the gray level of the implant, to compensate for minimal differences among radiographs, since the density of the metallic standard was the same in all specimens. 14 …”

Section: Radiographic Bone Densitymentioning

confidence: 99%

Experimental osteonecrosis: development of a model in rodents administered alendronate

et al. 2016

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Abstract:The main objective of this study was to cause bisphosphonate-related osteonecrosis of the jaws to develop in a rodent model. Adult male Holtzman rats were assigned to one of two experimental groups to receive alendronate (AL; 1 mg/kg/week; n = 6) or saline solution (CTL; n = 6). After 60 days of drug therapy, all animals were subjected to first lower molar extraction, and 28 days later, animals were euthanized. All rats treated with alendronate developed osteonecrosis, presenting as ulcers and necrotic bone, associated with a significant infection process, especially at the inter-alveolar septum area and crestal regions. The degree of vascularization, the levels of C-telopeptide cross-linked collagen type I and bone-specific alkaline phosphatase, as well as the bone volume were significantly reduced in these animals. Furthermore, on radiographic analysis, animals treated with alendronate presented evident sclerosis of the lamina dura of the lower first molar alveolar socket associated with decreased radiographic density in this area. These findings indicate that the protocol developed in the present study opens new perspectives and could be a good starting model for future property design.

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The Influence of Cyclosporin A on Mechanical Retention of Dental Implants Previously Integrated to the Bone: A Study in Rabbits

Abstract: Cyclosporin A administration may impair the mechanical retention of dental implants previously integrated to the bone.

Cited by 22 publications

References 18 publications

Effect of the long-term administration of Cyclosporine A on bone healing around osseointegrated titanium implants: A histomorphometric study in the rabbit tibia

Effect of the long-term administration of Cyclosporine A on bone healing around osseointegrated titanium implants: A histomorphometric study in the rabbit tibia

Systematic review of pre‐clinical models assessing implant integration in locally compromised sites and/or systemically compromised animals

Experimental osteonecrosis: development of a model in rodents administered alendronate

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