Systematic review of pre‐clinical models assessing implant integration in locally compromised sites and/or systemically compromised animals

Abstract

Objective: The aim was to systematically search the dental literature for pre-clinical models assessing implant integration in locally compromised sites (part 1) and systemically compromised animals (part 2), and to evaluate the quality of reporting of included publications. Methods: A Medline search was performed, complimented by additional hand searching. The quality of reporting of the included publications was evaluated using the 20 items of the ARRIVE (Animals in Research In Vivo Experiments) guidelines. Results: One-hundred and seventy-six (part 1; mean ARRIVE score = 15.6 ± 2.4) and 104 (part 2; 16.2 ± 1.9) studies met the inclusion criteria. The overall mean score for all included studies amounted to 15.8 ± 2.2. Housing (38.3%), allocation of animals (37.9%), numbers analysed (50%) and adverse events (51.4%) of the ARRIVE guidelines were the least reported. Statistically significant differences in mean ARRIVE scores were found depending on the publication date (p < 0.05), with the highest score of 16.7 ± 1.6 for studies published within the last 2 years. Conclusions: A large number of studies met the inclusion criteria. The ARRIVE scores revealed heterogeneity and missing information for selected items in more than 50% of the publications. The quality of reporting shifted towards betterreported pre-clinical trials within recent years.

Micro-CT analysis of the rodent jaw bone micro-architecture: A systematic review

“…Finally, it was observed that up to 70% of the studies did not provide information regarding randomization or blinding procedures. Based on previous systematic reviews on animals experiments [18], [48], it seems that the cited 3 methodological issues are generally neglected, even in the studies reporting that ARRIVE guidelines had been followed. Considering additional methodological information, only the study by Xu et al (2013) addressed the reproducibility of the evaluations performed by the examiner (in triplicate) and the time interval between each assessment ( in casu 2 weeks).…”

The effect of low‐level laser on bone healing in critical size defects treated with or without autogenous bone graft: an experimental study in rat calvaria

“…Preclinical studies are considered a transition stage after the accomplishment of in vitro studies and the first step to evaluate potential materials and techniques in vivo (Thoma et al. ).…”

A systematic review and meta‐analysis on the influence of biological implant surface coatings on periimplant bone formation

“…This is of interest, as in general, there are multiple studies analyzing implants under locally compromised conditions. 40 Since there already is a high clinical implant success rates in unimpaired bone, 41,42 it might be of higher clinical interest to analyze new implant surfaces under more critical circumstances, for example, under the influence of bone augmentation procedures. From a scientific point of view, it needs to be mentioned that this makes the interpretation of the results more complicated as further factors of influence will be introduced in such a study.…”