A systematic review and meta‐analysis on the influence of biological implant surface coatings on periimplant bone formation

Abstract

This systematic review and meta-analysis evaluated the influence of biological implant surface coatings on periimplant bone formation in comparison to an uncoated titanium reference surface in experimental large animal models. The analysis was structured according to the PRISMA criteriae. Of the1077 studies, 30 studies met the inclusion criteriae. Nineteen studies examined the bone implant contact (BIC) and were included in the meta-analysis. Overall, the mean increase in BIC for the test surfaces compared to the reference surfaces was 3.7 percentage points (pp) (95% CI -3.9-11.2, p = 0.339). Analyzing the increase in BIC for specific coated surfaces in comparison to uncoated reference surfaces, inorganic surface coatings showed a significant mean increase in BIC of 14.7 pp (95% CI 10.6-18.9, p < 0.01), extracellular matrix (ECM) surface coatings showed an increase of 10.0 pp (95% CI 4.4-15.6, p < 0.001), and peptide coatings showed a statistical trend with 7.1 pp BIC increase (95% CI -0.8-15.0, p = 0.08). In this review, no statistically significant difference could be found for growth factor surface coatings (observed difference -3.3 pp, 95% CI -16.5-9.9, p = 0.6). All analyses are exploratory in nature. The results show a statistically significant effect of inorganic and ECM coatings on periimplant bone formation. Abstract: This systematic review and meta-analysis evaluated the influence of biological implant surface coatings on periimplant bone formation in comparison to an uncoated titanium reference surface in experimental large animal models. The analysis was structured according to the PRISMA criteriae. Of the1077 studies, 30 studies met the inclusion criteriae. Nineteen studies examined the bone implant contact (BIC) and were included in the meta-analysis. Overall, the mean increase in BIC for the test surfaces compared to the reference surfaces was 3.7 percentage points (pp) (95% CI 23.9-11.2, p 5 0.339). Analyzing the increase in BIC for specific coated surfaces in comparison to uncoated reference surfaces, inorganic surface coatings showed a significant mean increase in BIC of 14.7 pp (95% CI 10.6-18.9, p < 0.01), extracellular matrix (ECM) surface coatings showed an increase of 10.0 pp (95% CI 4.4-15.6, p < 0.001), and peptide coatings showed a statistical trend with 7.1 pp BIC increase (95% CI 20.8-15.0, p 5 0.08). In this review, no statistically significant difference could be found for growth factor surface coatings (observed difference 23.3 pp, 95% CI 216.5-9.9, p 5 0.6). All analyses are exploratory in nature. The results show a statistically significant effect of inorganic and ECM coatings on periimplant bone formation.

Dental implant bioactive surface modifications and their effects on osseointegration: a review

“…Therefore, bioactive surface modifications on implant surfaces do not always offer a beneficial effect on osseointegration. This review is partially in line with the systematic review and meta-analysis conducted by Jenny et al [59]…”

“…One reason for the observed BIC variances in different animals could be the overall faster bone regeneration in dogs compared to pigs [59]. Therefore, the observed BIC may not reflect the actual effect of the specific type of surface modification on osseointegration in different animal models.…”

“…Another factor that may influence peri-implant bone formation is the anatomic location of the implant placement as the dynamics of bone formation differ in different locations. It was reported that the percentage of BIC for implants coated with growth factors increased in extraoral locations and decreased in intraoral ones [59]. Furthermore, the time of healing in different animals may also play a critical role in the aspect of osseointegration.…”

Effect of cathodic polarization on coating doxycycline on titanium surfaces

“…40 Surface functionalization using biologically active substances to influence the microenvironment around the dental implant with the aim to enhance interfacial healing processes and to prevent bacterial colonization represents a promising route to achieve improved implantation outcome, particularly in the compromised patient. This perception is reflected in the vast amount of ongoing research in this field, [79][80][173][174] and was the underlying motivation for the present thesis.…”

Immobilization of a carbon nanomaterial-based localized drug-release system using a bispecific material-binding peptide

“…Controlled surface modification of substrates is critical for the development of biomaterials that can interact with cells. [1][2][3][4] Surface modifications can be classified as physical, chemical, or biological. 5 In the chemical approach, various types of drug compounds are used as components of modifiers, which induce highly specific reactions in the biological system.…”