Effect of cathodic polarization on coating doxycycline on titanium surfaces

Abstract

Cathodic polarization has been reported to enhance the ability of titanium based implant materials to interact with biomolecules by forming titanium hydride at the outermost surface layer. Although this hydride layer has recently been suggested to allow the immobilization of the broad spectrum antibiotic doxycycline on titanium surfaces, the involvement of hydride in binding the biomolecule onto titanium remains poorly understood. To gain better understanding of the influence this immobilization process has on titanium surfaces, mirror-polished commercially pure titanium surfaces were cathodically polarized in the presence of doxycycline and the modified surfaces were thoroughly characterized using atomic force microscopy, electron microscopy, secondary ion mass spectrometry, and angle-resolved X-ray spectroscopy. We demonstrated that no hydride was created during the polarization process. Doxycycline was found to be attached to an oxide layer that was modified during the electrochemical process. A bacterial assay using bioluminescent Staphylococcus epidermidis Xen43 showed the ability of the coating to reduce bacterial colonization and planktonic bacterial growth.

Surface Topography Has Less Influence on Peri-Implantitis than Patient Factors: A Comparative Clinical Study of Two Dental Implant Systems

“…In fluoride content, DSO implants present a marginally higher percentage than an undetectable amount in STS implants; other studies also highlight the difference in contact angle between these two systems. − The incorporation of fluorine is due to the hydrofluoric treatment reported in the literature. , These differences in elemental composition suggest that the two types of implants, DSO and STS, undergo different surface treatments, resulting in slightly different surface chemistries that could influence their performance and osseointegration properties in clinical applications. , It is important to note that the presence of elements such as carbon may not just indicate the elemental composition of the implant itself but also adsorbed or residual substances from the environment during handling of the implants during XPS analysis. , Conforto et al identified the SLA surface top layer as TiH 1.971 , though our electron diffraction studies could not confirm this. Similar findings have been seen by others. , XPS analysis by others found the surface to be composed of TiO 2 [7], with an oxide layer thickness of 4.5–5.5 nm, including TiO and Ti 2 O 3. Thermal desorption spectroscopy revealed significant hydrogen in the subsurface layer of SLA compared to polished surfaces .…”

“…Similar findings have been seen by others. 72,73 XPS analysis by others found the surface to be composed of TiO 2 [7], with an oxide layer thickness of 4.5−5.5 nm, including TiO and Ti 2 O 3. 52 Thermal desorption spectroscopy revealed significant hydrogen in the subsurface layer of SLA compared to polished surfaces.…”

Is There a Better Biomaterial for Dental Implants than Titanium?—A Review and Meta-Study Analysis

“…Furthermore, polarization of the molecule (ampholyte) can be used for attachment to titanium in an electrochemical process. For example, two biomolecules, doxycycline and simvastatin, as coating candidates with such a technique have been reported [ 97 , 98 , 99 , 100 , 101 ].…”

The features of interaction between dental implants and organism tissues and the modern methods of creation of antibacterial covering on implant surfaces

“…Однако доксици клин связывался с оксидной пленкой, которая была изменена во время электрохимического процесса. Титан с таким способом модифицированной по верхностью резко снижал колонизацию и содержа ние в культуральной среде биолюминесцентного S. epidermidis Xen43 [39].…”