The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice

Abstract

Curcumin (diferuoyl methane) from turmeric is a well-known biologically active compound. It has been shown to ameliorate oxidative stress and it is considered to be a potent cancer chemopreventive agent. In our previous study the antioxidative effects of curcumin in cadmium exposed animals were demonstrated. Also manganese exerts protective effects in experimental cadmium intoxication. The present study examined the ability of the manganese complex of curcumin (Mn-curcumin) and curcumin to protect against oxidative damage and changes in trace element status in cadmium-intoxicated male mice. Curcumin or Mn-curcumin were administered at equimolar doses (0.14 mmol/kg b.w.) for 3 days, by gastric gavages, dispersed in methylcellulose. One hour after the last dose of antioxidants, cadmium chloride (33 micromol/kg) was administered subcutaneously. Both curcumin and Mn-curcumin prevented the increase of hepatic lipid peroxidation -- expressed as MDA level, induced by cadmium intoxication and attenuated the Cd-induced decrease of hepatic GSH level. No change in hepatic glutathione peroxidase or catalase activities was found in Cd-exposed mice. A decreased GSH-Px activity was measured in curcumin and Mn-curcumin alone treated mice. Neither curcumin nor Mn-curcumin treatment influenced cadmium distribution in the tissues and did not correct the changes in the balance of essential elements caused by Cd-treatment. The treatment with Mn-curcumin increased the Fe and Mn content in the kidneys of both control and Cd-treated mice and Fe and Cu content in the brain of control mice. In conclusion, regarding the antioxidative action, introducing manganese into the curcumin molecule does not potentiate the studied effects of curcumin.

Naringenin in Combination with Vitamins C and E Potentially Protects Oxidative Stress-Mediated Hepatic Injury in Cadmium-Intoxicated Rats

“…In the present study the activities of GR and G6PD significantly decreased in the liver tissues of Cd-treated rats. Our findings are in line with previous reports that showed depleted antioxidant activity in Cd-treated rats (49).…”

Effect of Curcumin Against Oxidation of Biomolecules by Hydroxyl Radicals

“…There was a significant decrease in MDA concentration in the curcumin treated samples due to antioxidative effect of curcumin. Our study data is in accordance with the studies of Eybl V et al, [36], Mahfouz MM et al, [37], Manju M et al, [38] showing significant antioxidant effect of curcumin on lipid peroxidation.…”

“…This was in agreement with Biswas SK et al, [45], who stated that curcumin can induce glutathione synthesis and increase the level of GSH and glutamylcysteine ligase catalytic subunit mRNA expression in oxidant and TNF α treated cells. The results in this study indicates that, curcumin may have profound effects on cellular redox control and similar to the studies of Eybl V et al, [36] and Sehgal A et al, [46].…”

Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium

“…Daniel et al (14) reported that CUR chelated Cd and lead in solutions and decreased lipid peroxidation induced by these metals in rat brain homogenate. Curcumin possesses antioxidative and anti-infl ammatory properties, and Eybl et al (15,16) associated it with a drop in Cd content in vivo in rats and mice.…”