Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium

Sevgiler, Yusuf; Karaytuğ, Süphan; Karayakar, Fahri

doi:10.2478/10004-1254-62-2011-2082

Cited by 23 publications

(17 citation statements)

References 37 publications

(36 reference statements)

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“…In this regard, curcumin and TQF (30 mg/kg and 100 mg/kg) are postulated to cause greater inhibition against H 2 O 2 production than that in the vehicle control along with prominent up regulation of GPx expression to an extent that prevailed the amount of H 2 O 2 . This is parallel to previous findings by Sevgiler et al whom reported that curcumin increased GPx levels while concomitantly lowered CAT activity in response to cadmium-induced oxidative stress [ 39 ]. Moreover, neither application of DMBA/TPA, curcumin nor TQF in the current study resulted in significant change in SOD levels as compared to the vehicle control.…”

Section: Discussionsupporting

confidence: 91%

Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion

Yeong

Hamid

Yazan

et al. 2015

BMC Complement Altern Med

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BackgroundDrastic increment of skin cancer incidence has driven natural product-based chemoprevention as a promising approach in anticancer drug development. Apart from its traditional usages against various ailments, Ardisia crispa (Family: Myrsinaceae) specifically its triterpene-quinone fraction (TQF) which was isolated from the root hexane extract (ACRH) was recently reported to exert antitumor promoting activity in vitro. This study aimed at determining chemopreventive effect of TQF against chemically-induced mouse skin tumorigenesis as well as elucidating its possible pathway(s).MethodsMice (n = 10) were initiated with single dose of 7,12-dimethylbenz[α]anthracene (DMBA) (390 nmol/100 μl) followed by, a week later, repeated promotion (twice weekly; 20 weeks) with 12-O-tetradecanoylphorbol-13-acetate (TPA) (1.7 nmol/100 μl). TQF (10, 30 and 100 mg/kg) and curcumin (10 mg/kg; reference) were, respectively, applied topically to DMBA/TPA-induced mice 30 min before each TPA application. Upon termination, histopathological and biochemical analysis, as well as Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and transcription factor enzyme-linked immunosorbent assay (ELISA) assays were performed to elucidate the potential mechanism of TQF.ResultsWith comparison to the carcinogen control, results revealed that lower dose of TQF (10 mg/kg) conferred antitumor promoting effect via significant (P < 0.05) suppression against lipid peroxidation (LPO), apoptotic index (cell death) and nuclear factor-kappa B (NF-κB), along with reduction of keratinocyte proliferation; whilst its higher dose (100 mg/kg) was found to promote tumorigenesis by significantly (P < 0.05) increasing LPO and apoptotic index, in addition to aggravating keratinocyte proliferation.ConclusionsThis study evidenced that TQF, particularly at its lower dosage (10 mg/kg), ameliorated DMBA/TPA-induced mouse skin tumorigenesis. Though, future investigations are warranted to determine the lowest possible therapeutic dose of TQF in subsequent in vivo chemopreventive studies.

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Section: Discussionsupporting

confidence: 91%

Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion

Yeong

Hamid

Yazan

et al. 2015

BMC Complement Altern Med

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“…Similarly, taurine was able to counteract oxidative stress induced by exposure to Cd in common carp ( Cyprinus carpio ) (Sevgiler et al . ). Taurine can also protect body cells against oxidation, by protecting mitochondrial integrity and respiration, as has been demonstrated in Atlantic salmon exposed to CdCl 2 (Espe & Holen ).…”

Section: Physiological Functions Of Taurine In Fishmentioning

confidence: 97%

Is dietary taurine supplementation beneficial for farmed fish and shrimp? a comprehensive review

El‐Sayed

2013

Reviews in Aquaculture

132

106

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Taurine is a neutral β‐amino acid derived from the metabolism of sulphur‐containing amino acids. It is present in high concentrations in animal tissues, especially heart, retina, skeletal muscle, brain, large intestines, plasma, blood cells and leucocytes. Therefore, this amino acid plays significant roles in many physiological functions, including membrane stabilization, antioxidation, detoxification, modulation of immune response, calcium transport, myocardial contractility, retina development, bile acid metabolism, osmotic regulation and endocrine functions. Historically, taurine has not been considered as an essential nutrient for fish. However, recent studies have indicated that taurine synthesis widely differs between fish species and demonstrated that it plays a key role in aquaculture and nutrition of freshwater and marine fish and shrimp. Animal proteins are rich in taurine, whereas plant proteins are taurine‐deficient. Therefore, fish fed plant protein–based food may require exogenous taurine for maintaining their physiological functions. Nevertheless, taurine may be conditionally indispensable for fish and shrimp, depending on dietary protein source, fish species and size, feeding habits, previous histories and the rate of metabolism of its precursors, namely cysteine and methionine. It is my belief that taurine functions in, and benefits for, farmed fish and shrimp are now more than worthy of critical review and analysis. This review summarizes the current knowledge on the roles of taurine in fish, particularly farmed fish and shrimp, with emphasis on taurine structure and biosynthesis, physiological functions, the effects of dietary taurine on fish performance and health and live food enrichment with taurine.

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“…Recent investigations have focused on therapeutic substances capable of reducing the genotoxicity or carcinogenicity of various natural and man-made mutagens. These substances include antibodies, fatty acids, amino acids, minerals, plant extracts, phenolic compounds, and boron compounds such as boric acid and borax (20)(21)(22)(23)(24)(25)(26).…”

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confidence: 99%

Anticancer and Antioxidant Properties of Terpinolene in Rat Brain Cells

Aydın

Türkez

Taşdemir

2013

Archives of Industrial Hygiene and Toxicology

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Terpinolene (TPO) is a natural monoterpene present in essential oils of many aromatic plant species. Although various biological activities of TPO have been demonstrated, its neurotoxicity has never been explored. In this in vitro study we investigated TPO's antiproliferative and/or cytotoxic properties using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) test, genotoxic damage potential using the single-cell gel electrophoresis (SCGE), and oxidative effects through total antioxidant capacity (TAC) and total oxidative stress (TOS) in cultured primary rat neurons and N2a neuroblastoma cells. Dose-dependent effects of TPO (at 10 mg L(-1), 25 mg L(-1), 50 mg L(-1), 100 mg L(-1), 200 mg L(-1), and 400 mg L(-1)) were tested in both cell types. Significant (P<0.05) decrease in cell proliferation were observed in cultured primary rat neurons starting with the dose of 100 mg L(-1) and in N2a neuroblastoma cells starting with 50 mg L(-1). TPO was not genotoxic in either cell type. In addition, TPO treatment at 10 mg L(-1), 25 mg L(-1), and 50 mg L(-1) increased TAC in primary rat neurons, but not in N2a cells. However, at concentrations above 50 mg L(-1) it increased TOS in both cell types. Our findings clearly demonstrate that TPO is a potent antiproliferative agent for brain tumour cells and may have potential as an anticancer agent, which needs to be further studied.

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Antioxidative Effects of N-acetylcysteine, Lipoic Acid, Taurine, and Curcumin in the Muscle of Cyprinus carpio L. Exposed to Cadmium

Cited by 23 publications

References 37 publications

Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion

Low dose triterpene-quinone fraction from Ardisia crispa root precludes chemical-induced mouse skin tumor promotion

Is dietary taurine supplementation beneficial for farmed fish and shrimp? a comprehensive review

Anticancer and Antioxidant Properties of Terpinolene in Rat Brain Cells

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