The Influence of Corticosteroids on Normal and Papain-Treated Articular Cartilage in the Rabbit

Shaw, N. E.; Lacey, Eve

doi:10.1302/0301-620x.55b1.197

Cited by 26 publications

(10 citation statements)

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“…Unlike aspirin-treated cartilage, there is a direct correlation between proteoglycan content and [3sS]sulfate uptake and incorporation. These findings do not correlate with those seen by Shaw and Lacey [34] in which they found a marked and persistent inhibiton of recovery from papain degradation in animals treated with corticosteroids.…”

Section: Hydrocortisone Treatment (Experiments 2)contrasting

confidence: 99%

Effects of anti-inflammatory drugs on cartilage recovery from catabolin-induced degradation

Strathy

Gorski

1987

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Effects of aspirin (200 micrograms/ml), hydrocortisone (10 micrograms/ml), sodium aurothiomalate (100 micrograms/ml), and indomethacin (10 micrograms/ml) on recovery of cartilage from interleukin 1 or catabolin-induced degradation were examined in this initial in vitro study. The experimental protocol involved a "degradative phase" of eight days during which cartilage plugs were incubated in the presence or absence of spent human rheumatoid synovial culture media. A "recovery" period of six days followed during which the effects of the aforementioned drugs on treated cartilage were analyzed. Incorporation of [35S]sulfate and [3H]proline precursors, and total contents of hydroxyproline and glycosaminoglycan in cartilage were determined two, four, and six days after insult. Aspirin treatment caused a rise in total proteoglycan content over degraded controls (p less than 0.002), however, this increase was not associated with increased [35S]sulfate incorporation into glycosaminoglycans. Hydrocortisone resulted in a delayed rise in proteoglycan content concommitant with increased [35S]sulfate uptake, whereas sodium aurothiomalate treatment was without effect on proteoglycans. Indomethacin treatment was associated with an increased release of newly synthesized macromolecules by cartilage into the media (p less than 0.01). These results suggest that common anti-inflammatory drugs may exhibit distinctly different effects on the in vitro synthesis and retention of proteoglycans by cartilage explants previously exposed to a degradative phase. Further work is necessary to assess the influence of drug concentration in this experimental system.

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Section: Hydrocortisone Treatment (Experiments 2)contrasting

confidence: 99%

Effects of anti-inflammatory drugs on cartilage recovery from catabolin-induced degradation

Strathy

Gorski

1987

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“…The net effect seems to be negligible where there is little functional demand on the chondrocyte (Kaplan and Fisher, 1964), but profound deleterious changes may occur in growing cartilage, in adult cartilage under abnormal mechanical stress, or when high doses are administered (Barrett et aL, 1966;Mankin et aL, 1971;Shaw and Lacey, 1973;Olah and Kostenszky, 1976).…”

Section: Cortisonementioning

confidence: 99%

Metabolism of Cartilage

Stockwell¹

1983

Cartilage

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“…The selection of papers is summarized in Figure . Thirty‐five studies were selected , with seven published between 1965 and 1970, 5 between 1971 and 1980, 6 between 1981 and 1990, 14 between 1991 and 2000, 2 between 2001 and 2010, and 1 in 2014. They reported the effects of hydrocortisone acetate (HAC) ( n = 9); methylprednisolone acetate (MPA) ( n = 13); triamcinolone acetonide (TA) ( n = 3); hexacetonide (TH) ( n = 5); betamethasone acetate (BA), phosphate (BP), and dipropionate (BDP) ( n = 4); and dexamethasone (DEX) ( n = 1).…”

Section: Resultsmentioning

confidence: 99%

“…Historically, it is in rabbits that the first animal studies were conducted ( Table ). Most studies were performed in healthy animals , except for four studies investigating the effects of CS on experimentally induced OA .…”

Section: Discussionmentioning

confidence: 99%

“…Historically, it is in rabbits that the first animal studies were conducted (Table II). Most studies were performed in healthy animals [12][13][14][15]17,[19][20][21][22][23][24]27,37,45], except for four studies investigating the effects of CS on experimentally induced OA [16,18,25,46]. Early studies showed that IA administration of HAC induces a reduction of proteins in cartilage extracellular matrix [12,13] or induced structural changes of normal cartilage [14,15] in a dose-dependent manner, and this can occur after the first or second treatments.…”

Section: Rabbitsmentioning

confidence: 99%

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Effect of corticosteroids on articular cartilage: have animal studies said everything?

Vandeweerd

Zhao

Nisolle

et al. 2015

Fundamemntal Clinical Pharma

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Intra-articular (IA) corticosteroids (CS) have been used in the treatment of osteoarthritis for many years, although their effects on articular cartilage are not fully understood. To identify whether previous animal studies have provided enough evidence about the effects of CS, we undertook a systematic review that identified 35 relevant in vivo animal experimental studies between 1965 and 2014 assessing the effects of CS on either normal cartilage, or in either induced osteoarthritis (OA) or synovitis. The quality of the methodology was assessed. Deleterious effects, both structural and biochemical, have mainly been reported in rabbits and are associated with frequent administration of CS, sometimes at high dose and with systemic side effects. In dogs, four identified studies concluded that there were beneficial effects with methylprednisolone acetate (MPA) and triamcinolone hexacetonide therapy. In horses, MPA was mostly deleterious, while triamcinolone acetonide had positive effects in one study highly rated at quality assessment. However, many methodological weaknesses have been identified, such as the lack of pharmacokinetic and pharmocodynamics data and the large variation in doses between studies, the limited selection criteria at baseline, the absence of blinding, and the lack of statistics or appropriate controls for testing the effects of the vehicle of the drug. Those methodological weaknesses weaken the conclusions of numerous studies that assess beneficial or deleterious effects of CS on articular cartilage. Animal studies have not yet provided definitive data, and further research is required into the role of CS in articular pathobiology.

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The Influence of Corticosteroids on Normal and Papain-Treated Articular Cartilage in the Rabbit

Cited by 26 publications

References 0 publications

Effects of anti-inflammatory drugs on cartilage recovery from catabolin-induced degradation

Effects of anti-inflammatory drugs on cartilage recovery from catabolin-induced degradation

Metabolism of Cartilage

Effect of corticosteroids on articular cartilage: have animal studies said everything?

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