The Influence of Controlled Limb Reperfusion With PGE1 on Reperfusion Injury After Prolonged Ischemia

Abdel-Rahman, Ulf; Risteski, Petar; Klaeffling, Christina; Mitrev, Zan; Ackermann, Hanns; Matheis, G.; Moritz, Anton; Beyersdorf, Friedhelm

doi:10.1016/j.jss.2008.10.005

Cited by 7 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Huk et al investigated the role of PGE 1 in NO production in the setting of skeletal muscle I/R injury and hypothesized that there exists an inverse relationship between PGE 1 and nitric oxide levels (24). Abdel-Rahman et al reported that PGE 1 reduced the local hemodynamic effects of I/R injury in addition to controlling reperfusion, primarily via the attenuation of the "reflow paradox" (25). However, the exact effect of PGE 1 on I/R injury was not clear, as PGE 1 was not used in the setting of uncontrolled reperfusion in the study in question.…”

Section: Discussionmentioning

confidence: 99%

The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle

et al. 2017

View full text Add to dashboard Cite

Background/aim: The protective effects of prostaglandin (PG) analogs on ischemia-reperfusion (I/R) have been well documented; however, comparative studies are lacking. The aim of the present study was to determine whether iloprost or alprostadil is more effective in preventing muscle I/R injury.Materials and methods: Thirty-two rats were divided into four groups (n = 8): sham, control, IL (I/R + iloprost), and AL (I/R + alprostadil). I/R was induced by a tourniquet in the hindlimb for 3 h/3 h. The IL and AL groups received iloprost (0.5 ng kg -1 min -1 ) and alprostadil (0.05 µg kg -1 min -1 ) during reperfusion, respectively. After 6 h, blood and muscles were collected for analyses.Results: Serum TNF-α and IL-1β levels were decreased in the IL and AL groups compared with the control group (P < 0.05), whereas IL-6 levels did not change significantly. Tissue malondialdehyde levels were significantly lower in the IL and AL groups (P < 0.05). Tissue catalase levels showed no difference. The histological damage scores and apoptosis scores were both significantly decreased in the IL and AL groups compared with the control group (P< 0.05). Conclusion:The present study indicated that iloprost and alprostadil attenuated I/R injury in skeletal muscle. However, no comparable difference was evident regarding the efficacies of either PG analog.

show abstract

Section: Discussionmentioning

confidence: 99%

The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In this study, we used an ischemia reperfusion injury model of rabbit's thigh to compare the alleviation of prefasciotomy and postfasciotomy in reperfusion injury. Porcine latissimus dorsi flap reperfusion model [ 19 , 20 ] was commonly used for limb skeletal muscle ischemia reperfusion injury. However, the preparation of this model is complex, and the cost is relatively high.…”

Section: Discussionmentioning

confidence: 99%

The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits

Jin

Kan

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

The authors aim to investigate protective effects of fasciotomy against ischemia reperfusion injury of skeletal muscle in rabbit and to compare the treatment effects of prereperfusion + fasciotomy and fasciotomy + postreperfusion against ischemia reperfusion injury of skeletal muscle. 24 healthy male Japanese white rabbits were randomly divided into 3 groups, and 4 hours' ischemia was established in these rabbits through surgery. Six hours' reperfusion was performed in group A; reperfusion + postfasciotomy was performed in group B; and prefasciotomy + reperfusion was performed in group C. Result showed that prefasciotomy and postfasciotomy could protect skeletal muscle against ischemia reperfusion injury, reduced MDA (malondialdehyde) expression, MPO (myeloperoxidase) expression, and apoptosis of muscle in the reperfused areas, increased Bcl-2 expression, and decreased Bax expression. The MDA and MPO levels in group B and group C were significantly lower than those in group A, and MDA and MPO levels in group C were significantly lower than those in group B. Prefasciotomy and postfasciotomy could protect against ischemia reperfusion injury in skeletal muscle. The protective effects of prefasciotomy against ischemia reperfusion injury are better than postfasciotomy.

show abstract

“…Rapid surgical restoration of flow is a recognized contributor to injury, and several groups have investigated the impact of controlled reperfusion following prolonged ischemia. 17,27 This reperfusion injury could have been treated via fasciotomy and ultimately resulted in improved neuromuscular recovery. Subsequent studies are underway to evaluate the independent impact of treating these reperfusion injuries with surgical decompression (fasciotomy) on shifting the ischemic threshold.…”

Section: Figmentioning

confidence: 99%

“…[9][10][11][12][13] Additionally, the importance of immediate (eg, vascular repair) compared with delayed restoration of flow or even ligation and reperfusion through native or collateral processes has been recognized but incompletely characterized. [14][15][16][17] To date, models describing serial functional assessment after large, axial vessel injury treated by repair or ligation are lacking.…”

mentioning

confidence: 99%

The impact of ischemic intervals on neuromuscular recovery in a porcine (Sus scrofa) survival model of extremity vascular injury

Burkhardt

Gifford

Propper

et al. 2011

Journal of Vascular Surgery

View full text Add to dashboard Cite

In this model, surgical and therapeutic adjuncts to restore extremity perfusion early (1-3 hours) after extremity vascular injury are most likely to provide outcomes benefit compared with delayed restoration of flow or ligation. Furthermore, the ischemic threshold of the extremity after which neuromuscular recovery is significantly diminished is less than 5 hours. Additional studies are necessary to determine the effect of other factors such as shock or therapeutic measures on this ischemic threshold.

show abstract

The Influence of Controlled Limb Reperfusion With PGE1 on Reperfusion Injury After Prolonged Ischemia

Cited by 7 publications

References 25 publications

The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle

The effects of iloprost and alprostadil on ischemia-reperfusion injury in preventing inflammation, tissue degeneration, and apoptosis in rat skeletal muscle

The Protective Effects of Fasciotomy on Reperfusion Injury of Skeletal Muscle of Rabbits

The impact of ischemic intervals on neuromuscular recovery in a porcine (Sus scrofa) survival model of extremity vascular injury

Contact Info

Product

Resources

About