The Influence of Chemokine CXCR4 and Cyclooxygenase-2 in the Recurrence of Pterygium

Baser, Gonen; Sivrikoz, Oya Nermin; Karahan, Eyyüp; Ün, Emine Şeker; Yıldırım, Hakan

doi:10.3109/09273948.2015.1116588

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…The current understanding of the pathogenesis of pterygium implicates multifactorial mechanisms including ultraviolet (UV) exposure (Threlfall and English, 1999), oxidative stress (Kau et al, 2006; Balci et al, 2011), anti-apoptotic factors (Tan et al, 2000; Liang et al, 2011), inflammatory mediators (Baser et al, 2016), immunologic mediators (Di Girolamo et al, 2002), viral infections (Hsiao et al, 2010), genetic factors (Weinstein et al, 2002), extracellular matrix modulators (Tsai et al, 2010) and growth factors (Kria et al, 1996; Kria et al, 1998; Jin et al, 2003; Nolan et al, 2003). A detailed discussion of these pathogenic factors is beyond the scope of this review and is proficiently covered in other comprehensive reviews (see Di Girolamo et al, 2004; Chui et al, 2008; Liu et al, 2013; Cardenas-Cantu et al, 2014).…”

Section: Pterygiummentioning

confidence: 99%

Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

Shu

Lovicu

2017

Progress in Retinal and Eye Research

281

239

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Wound healing is one of the most complex biological processes to occur in life. Repair of tissue following injury involves dynamic interactions between multiple cell types, growth factors, inflammatory mediators and components of the extracellular matrix (ECM). Aberrant and uncontrolled wound healing leads to a non-functional mass of fibrotic tissue. In the eye, fibrotic disease disrupts the normally transparent ocular tissues resulting in irreversible loss of vision. A common feature in fibrotic eye disease is the transdifferentiation of cells into myofibroblasts that can occur through a process known as epithelial-mesenchymal transition (EMT). Myofibroblasts rapidly produce excessive amounts of ECM and exert tractional forces across the ECM, resulting in the distortion of tissue architecture. Transforming growth factor-beta (TGFβ) plays a major role in myofibroblast transdifferentiation and has been implicated in numerous fibrotic eye diseases including corneal opacification, pterygium, anterior subcapsular cataract, posterior capsular opacification, proliferative vitreoretinopathy, fibrovascular membrane formation associated with proliferative diabetic retinopathy, submacular fibrosis, glaucoma and orbital fibrosis. This review serves to introduce the pathological functions of the myofibroblast in fibrotic eye disease. We also highlight recent developments in elucidating the multiple signaling pathways involved in fibrogenesis that may be exploited in the development of novel anti-fibrotic therapies to reduce ocular morbidity due to scarring.

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Section: Pterygiummentioning

confidence: 99%

Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

Shu

Lovicu

2017

Progress in Retinal and Eye Research

281

239

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“…Ocular surface inflammation is broadly accepted to play a prominent role in the initial pterygium pathogenesis and in its recurrence [10, 14]. Interestingly, soluble factors contained within tears can provide insight into the pathophysiological state of the ocular surface as they reflect the ongoing intercellular communication [15].…”

Section: Introductionmentioning

confidence: 99%

Pterygium Pathology: A Prospective Case-Control Study on Tear Film Cytokine Levels

Acker

Haagdorens

Roelant

et al. 2019

Mediators of Inflammation

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Pterygium is a common eye disease, linked to an increased exposure to UV radiation and dry environments. The associated pathology culminates in visual impairment and, in some rare cases, blindness. However, there remains a lot of uncertainty concerning the pathogenesis of this fibrovascular lesion. As the composition of the tear film provides a reflection into the pathological changes at the ocular surface, tear analysis represents an ideal approach to gain insight in the progression of disease following pterygiectomy. This study enrolled 19 patients and age/gender-matched healthy controls. Tear film levels of interleukin- (IL-) 6, IL-8, and vascular endothelial growth factor (VEGF) were investigated over time, and preoperative concentrations were linked to corneal neovascularization and pterygium size. Diminished tear film levels were found in unilateral patients who show no clinical signs of pterygium recurrence over a period of one year. Hence, our results highlight the potential of using the course of IL-6, IL-8, and VEGF levels in tears as biomarkers for recovery. In addition, when focusing on the affected eyes (i.e., primary and recurrent pterygium), we detected fold changes in preoperative cytokine concentrations to correspond with disease severity. As our proposed biomarkers did not reveal a linear relationship with corneal neovascularization nor the invasive behaviour of pterygium, no exact role in the pterygium pathology could be established. Hence, our data point to these factors being contributors rather than decisive players in the pathological processes.

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The Influence of Chemokine CXCR4 and Cyclooxygenase-2 in the Recurrence of Pterygium

Abstract: CXCR4 and cyclooxygenase-2 may play an important role in the recurrence of pterygium.

Cited by 2 publications

References 21 publications

Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis

Pterygium Pathology: A Prospective Case-Control Study on Tear Film Cytokine Levels

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