The Influence of Charge on the Deposition Behavior of Aerosol Particles with Emphasis on Singly Charged Nanometer Sized Particles

Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger

“…Finlay (31) estimated that the number of elementary charges should be at least 30 to see a charge effect on a 1 μm particle in the alveolar region (31). This level of charge was found to be a good estimate based on the in vivo study of Melandri et al (13), where they noticed an effect of charge on particle deposition within the size range of 0.6–1 μm, where the number of elementary charges was approximately 30 and higher (13, 25). …”

“…Increases in deposition due to electrical charge of spherical and fibrous particles have previously been demonstrated using animals, clinical studies in humans, in vitro studies with airway replicas and mathematical modeling (10–23) and have recently been reviewed by Wong et al (24) and previously by Cohen et al (25). Bailey et al were the first to suggest taking advantage of electrical charge to improve lung retention and to target the aerosols to different regions of the respiratory system by controlling the particle size and charge together with the breathing conditions (5, 9).…”

“…Previous studies have demonstrated the effect of charge on the deposition of micrometer (14, 18–20, 23, 26) and submicrometer particles (13, 16, 25) in human airways and on boundary surfaces (27–30). The study of Melandri et al (13) reported the deposition of charged monodisperse aerosols with diameters of 1 μm or less in the airways of human subjects breathing normally.…”

Performance study of a DC-corona-based particle charger for charge conditioning

“…Examples of applications via charged particles are the synthesis of unagglomerate particles (Adachi, Tsukui, & Okuyama, 2003;Jiang, Chen, & Biswas, 2007), particle separation and removal (Parker, 1997), particle collection (Cheng, Yeh, & Kanapilly, 1981), enhanced particle dispersion (Mazumder et al, 2007)), structured patterning (Fissan, Kennedy, Krinke, & Kruis, 2003;Jacobs & Whitesides, 2001;Kim et al, 2006), micro-contamination control (Zhuang, Kim, Lee, & Biswas, 2000), and particle instrumentation (Chen et al, 1998;Friedlander & Pui, 2003;Kaufman et al, 2002;Keskinen, Pietarinen, & Lehtimäki, 1992;Shin, Pui, Fissan, Neumann, & Trampe, 2007;Wang et al, 2010). Particle deposition in the human lung was also found to be dramatically enhanced by electrical charges on particles (Cohen, Xiong, Fang, & Li, 1998;Cohen, Xiong, & Li, 1996;Melandri et al, 1983;Yu, 1985). Using inhalation for rapid drug absorption in the lung and subsequently systemic transport to secondary body organs can be efficiently achieved by the administration of charged aerosol medications.…”

Ultrafine particles in urban ambient air and their health perspectives

“…Benzo[a]pyrene, indeno-pyrene, and dibenzanthracene comprises 90% of the total PAHs in traffic-related UfPs 5. Accumulation of cellular proteins, lipids, carbohydrates, and nucleic acids in the form of attenuated microbes can deliver an electrical charge that may make the deposition process more complex and retention time longer (21).…”