The Influence of Central Corneal Thickness on Intraocular Pressure Measured by Goldmann Applanation Tonometry Among Selected Ethiopian Communities

Gelaw, Yeshigeta; Kollmann, Martin; Irungu, Njuguna M.; Ilako, D

doi:10.1097/ijg.0b013e3181ca7708

Cited by 18 publications

(29 citation statements)

References 16 publications

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“…Although office-based tonometry is a useful technique, it is dependent on corneal properties that often lead to measurement errors. [66][67][68][69] Furthermore, testing only involves brief measurements four times a year and the measurements do not adequately reflect diurnal and longer-term IOP variability.…”

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confidence: 99%

Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement inex vivononhuman primate eyes

et al. 2012

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Abstract. Glaucoma is a blinding disease for which intraocular pressure (IOP) is the only treatable risk factor. The mean IOP is regulated through the aqueous outflow system, which contains the trabecular meshwork (TM). Considerable evidence indicates that trabecular tissue movement regulates the aqueous outflow and becomes abnormal during glaucoma; however, such motion has thus far escaped detection. The purpose of this study is to describe anovel use of a phase-sensitive optical coherence tomography (PhS-OCT) method to assess pulsedependent TM movement. For this study, we used enucleated monkey eyes, each mounted in an anterior segment holder. A perfusion system was used to control the mean IOP as well as to provide IOP sinusoidal transients (amplitude 3 mmHg, frequency 1 pulse/second) in all experiments. Measurements were carried out at seven graded mean IOPs (5,8,10,20,30,40, and 50 mm Hg). We demonstrate that PhS-OCT is sensitive enough to image/ visualize TM movement synchronous with the pulse-induced IOP transients, providing quantitative measurements of dynamic parameters such as velocity, displacement, and strain rate that are important for assessing the biomechanical compliance of the TM. We find that the largest TM displacement is in the area closest to Schlemm's canal (SC) endothelium. While maintaining constant ocular pulse amplitude, an increase of mean IOP results in a decrease of TM displacement and mean size of the SC. These results demonstrate that the PhS-OCT is a useful imaging technique capable of assessing functional properties necessary to maintain IOP in a healthy range, offering a new diagnostic alternative for glaucoma.

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Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement inex vivononhuman primate eyes

et al. 2012

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“…A positive, but inconsistent association between CCT and IOP was found in South Africa [28], IOP is significantly affected by CCT in Ethiopia and Nigeria [9,29], CCT was negatively correlated with age in Cameroon [10], and there was no significant association between CCT and IOP in Nigeria [26]. Elsewhere, there was a strong correlation between CCT and IOP among the non-glaucomatous population.…”

Section: IImentioning

confidence: 99%

“…Perhaps this maximum value for children (maximum value) is just confirmation of some constatation, showed the CCT was thinner for older than for younger age. It was found of many studies led in SSA [9,10,24,25,26,27] such as elsewhere [6,32,33]. And that study showed no statistically significant difference in CCT between the age groups [23].…”

Section: IImentioning

confidence: 99%

“…CCT for non glaucomatous subjects 1637 non-glaucomatous patients drawn from 5 sub-Saharan countries (South Africa, Nigeria, Ghana, Cameroon, Ethiopia) were assessed after collection of the articles from Pubmed database, Google, Embase [9,10,23,24,25,26,27,28,29,30] The largest cluster of average CCT for non-glaucomatous African subjects was between 512.4 and 550 µm.…”

Section: IImentioning

confidence: 99%

“…For every 30 mm difference in CCT from the mean in either way, there was an approximately 1.1mm Hg difference in the estimated IOP from the mean IOP (13.40mm Hg) [9]. A rise in CCT by 100 μm was followed by an increase in IOP of about 2.8 mmHg for both eyes taken together [10].…”

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confidence: 99%

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Central Corneal Thickness Measurement in Sub-Saharan Africa: Review

Soatiana¹,

Christiane²,

Kpoghoumou³

et al. 2014

IOSRJHSS

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Central corneal thickness in southern Egypt

Mostafa

2013

Int Ophthalmol

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The study aimed to determine mean central corneal thickness (CCT) in a southern Egyptian population according to gender and age using ultrasonic pachymetry and to compare these CCT measurements to different populations. A prospective, observational, consecutive case series of 4,368 non-glaucomatous subjects (emmetropes and myopes) aged 16-70 years was carried out from August 2010 to March 2013 at the outpatient ophthalmology clinic in Sohag University Hospital and the Laser Vision Center in Sohag City, Egypt. Refraction, keratometry, slit-lamp examination, and intraocular pressure (IOP) measurements were obtained for all subjects. CCT was measured by ultrasonic pachymetry. The average CCT was 530.06 ± 38.03 μm. Average CCT was 532.6 ± 33.3 μm in emmetropes, 531.5 ± 31.3 μm in myopes <6 diopters (D), 531.1 ± 31.4 μm in myopes >6 D and 533 ± 33 μm in hyperopes, with no statistically significant difference between the groups. There was a statistically significant difference in CCT between age groups and gender. There was a strong correlation between CCT and IOP among the non-glaucomatous population. CCT was found to be lower in Egyptians than in Caucasian, Hispanic, and Japanese populations but comparable to African and African American populations.

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The Influence of Central Corneal Thickness on Intraocular Pressure Measured by Goldmann Applanation Tonometry Among Selected Ethiopian Communities

Abstract: The CCT of Ethiopians is thin and hence can result in underestimation of IOP measured by GAT.

Cited by 18 publications

References 16 publications

Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement inex vivononhuman primate eyes

Phase-sensitive optical coherence tomography characterization of pulse-induced trabecular meshwork displacement inex vivononhuman primate eyes

Central Corneal Thickness Measurement in Sub-Saharan Africa: Review

Central corneal thickness in southern Egypt

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