The influence of Calendulae officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts

Matysik, G.; Wójciak–Kosior, Magdalena; Paduch, Roman

doi:10.1016/j.jpba.2004.12.034

Cited by 58 publications

(48 citation statements)

References 14 publications

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“…In contrast to the lack of studies with M. cervina in this regard, there are some reports that evaluate the antitumor activity of C. officinalis extracts and isolated compounds by using in vitro and in vivo models. 7,21,22 The antitumor activity of triterpene glycosides isolated from marigold was shown by Ukiya et al, 7 and the results obtained by Matić et al 22 on marigold infusion against HeLa (GI 50 = 750 µg mL −1 ) and other tumor cell lines, are consistent with the present study. In summary, C. officinalis (marigold flowers) and M. cervina (Hart's pennyroyal leaves) contain phytochemicals that are of great interest due to their potential antioxidant and antitumor activities.…”

Section: View Article Onlinesupporting

confidence: 92%

Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)

et al. 2016

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aThe chemical composition and bioactive properties of two plants (Calendula officinalis L. and Mentha cervina L.) were studied. Their nutritional value revealed a high content of carbohydrates and low fat levels, and very similar energy values. However, they presented different profiles in phenolic compounds and fatty acids; C. officinalis presented mainly glycosylated flavonols and saturated fatty acids, while M. cervina presented mainly caffeoyl derivatives and polyunsaturated fatty acids. M. cervina showed the highest concentration of phenolic compounds while C. officinalis presented higher amounts of sugars, organic acids and tocopherols. The highest antioxidant and cytotoxic activities were obtained for the hydromethanolic extract of M. cervina, which presented the lowest values of EC 50 and exhibited cytotoxicity against the four tumor cell lines tested. Infusions showed no cytotoxicity for the tumor cell lines, and none of the extracts showed toxicity against non-tumor cells. This study contributes to expand the knowledge on both natural sources and therefore their use.

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Section: View Article Onlinesupporting

confidence: 92%

Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)

et al. 2016

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“…Isoquercitrin in cancer above 25 µg/mL, stimulated cell proliferation and cellular metabolism by increasing mitochondrial activity. However, concentrations higher than 75 µg/mL were cytotoxic [75] . Yang et al [76] assessed the synergistic effects of Q3G and apple extract in breast cancer cells.…”

Section: First Maximummentioning

confidence: 94%

“…In 2005, Matysik et al [75] showed that Calendulae officinalis flos (Asteraceae), which contains IQ, had two biological effects in human skin fibroblast and human breast cancer cells (T47D). Extracts at concentrations …”

Section: Breast Cancermentioning

confidence: 99%

Review of anticancer mechanisms of isoquercitin

Orfali¹,

Duarte²,

Bonadio³

et al. 2016

WJCO

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This review was based on a literature search of PubMed and Scielo databases using the keywords "quercetin, rutin, isoquercitrin, isoquercitin (IQ), quercetin-3-glucoside, bioavailability, flavonols and favonoids, and cancer" and combinations of all the words. We collected relevant scientific publications from 1990 to 2015 about the absorption, bioavailability, chemoprevention activity, and treatment effects as well as the underlying anticancer mechanisms of isoquercitin. Flavonoids are a group of polyphenolic compounds widely distributed throughout the plant kingdom. The subclass of flavonols receives special attention owing to their health benefits. The main components of this class are quercetin, rutin, and IQ, which is a flavonoid and although mostly found as a glycoside, is an aglycone (lacks a glycoside side chain). This compound presents similar therapeutic profiles to quercetin but with superior bioavailability, resulting in increased efficacy compared to the aglycone form. IQ has therapeutic applications owing to its wide range of pharmacological effects including antioxidant, antiproliferative, anti-inflammatory, anti-hypertensive, and anti-diabetic. The protective effects of IQ in cancer may be due to actions on lipid peroxidation. In addition, the antitumor effect of IQ and its underlying mechanism are related to interactions with Wnt signaling pathway, mixed-lineage protein kinase 3, mitogen-activated protein kinase, apoptotic pathways, as well proinflammatory protein signaling. This review contributed to clarifying the mechanisms of absorption, metabolism, and actions of IQ and isoquercitrin in cancer.

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“…Marigold extract from flowers stimulated EPCs proliferation at concentrations lower than the marigold green plant extract, which can be explained by the presence of more abundant active compounds contained in marigold flowers, such as pentacyclic triterpene, trihydroxyalcohols, flavonoids, saponins, carotenoids, and phenolic acids that have been suggested to present anti-inflammatory and wound-healing properties [9,31,32].…”

Section: Discussionmentioning

confidence: 99%

Effects of plant lectin and extracts on adhesion molecules of endothelial progenitors

Iordache¹,

Iordache²,

et al. 2011

Open Life Sciences

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Promise of cell therapy has advanced the use of adult stem cells towards the development of novel approaches to promote regeneration of injured endothelium. The aim of this study was to stimulate endothelial progenitor cells (EPCs) with lectin isolated from Solanum tuberosum (potato) shoot and Calendula officinalis (marigold) extracts, in order to increase EPCs proliferation and gene expression of molecules with roles in chemotaxis and adhesion for a better attachment to injured vascular tissue. EPCs were differentiated from umbilical cord blood-derived mononuclear cells and characterized by light microscopy, flow cytometry, and vascular tube-like structures formation on Matrigel. Cell proliferation was determined by MTS assay, and gene expression of molecules involved in EPCs adhesion (VCAM-1, VE-cadherin, ICAM-1, PECAM-1, P-selectin) and chemotaxis was determined (CXCR4, Tie-2) by RT-PCR. For the assessment of cell motility, wound-healing assay was employed. Both potato shoot lectin and marigold extracts stimulated EPCs proliferation in a concentration dependent manner and were able to increase expression of adhesion and chemotactic molecules. Marigold flower extract proved to be more efficient. This study demonstrates the usefulness of potato lectin and marigold extracts to increase EPCs proliferation and modulate gene expression of chemotactic and adhesion molecules, which may facilitate EPCs attachment to injured endothelium.

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The influence of Calendulae officinalis flos extracts on cell cultures, and the chromatographic analysis of extracts

Cited by 58 publications

References 14 publications

Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)

Chemical characterization and bioactive properties of two aromatic plants: Calendula officinalis L. (flowers) and Mentha cervina L. (leaves)

Review of anticancer mechanisms of isoquercitin

Effects of plant lectin and extracts on adhesion molecules of endothelial progenitors

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