The influence of brain death on donor liver and the potential mechanisms of protective intervention

Zhang, Shuijun; Wang, Tao

doi:10.1007/s11684-011-0109-y

Cited by 12 publications

(11 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[70][71][72] It is quite possible that the SCI initiates a similar ''neurogenic disease'' state in peripheral organs and contributes to the overall poor health and reduced longevity in the SCI population. The peripheral liver dysfunction in turn could potentially contribute to spinal cord dysfunction because hepatic myelopathy has been described in patients presenting with progressive spasticity and paresis.…”

Section: Sauerbeck Et Almentioning

confidence: 99%

Spinal Cord Injury Causes Chronic Liver Pathology in Rats

Sauerbeck

Laws

Bandaru

et al. 2015

Journal of Neurotrauma

View full text Add to dashboard Cite

Traumatic spinal cord injury (SCI) causes major disruption to peripheral organ innervation and regulation. Relatively little work has investigated these post-SCI systemic changes, however, despite considerable evidence that multiple organ system dysfunction contributes to chronic impairments in health. Because metabolic dysfunction is common after SCI and the liver is a pivotal site for metabolic homeostasis, we sought to determine if liver pathology occurs as a result of SCI in a rat spinal contusion model. Histologic evidence showed excess lipid accumulation in the liver for at least 21 days post-injury after cervical or midthoracic SCI. Lipidomic analysis revealed an acute increase in hepatic ceramides as well as chronically elevated lactosylceramide. Post-SCI hepatic changes also included increased proinflammatory gene expression, including interleukin (IL)-1a, IL-1b, chemokine ligand-2, and tumor necrosis factor-a mRNA. These were coincident with increased CD68 + macrophages in the liver through 21 days post-injury. Serum alanine transaminase, used clinically to detect liver damage, was significantly increased at 21 days post-injury, suggesting that early metabolic and inflammatory damage preceded overt liver pathology. Surprisingly, liver inflammation was even detected after lumbar SCI. Collectively, these results suggest that SCI produces chronic liver injury with symptoms strikingly similar to those of nonalcoholic steatohepatitis (fatty liver disease). These clinically significant hepatic changes after SCI are known to contribute to systemic inflammation, cardiovascular disease, and metabolic syndrome, all of which are more prevalent in persons with SCI. Targeting acute and prolonged hepatic pathology may improve recovery and reduce long-term complications after SCI.

show abstract

Section: Sauerbeck Et Almentioning

confidence: 99%

Spinal Cord Injury Causes Chronic Liver Pathology in Rats

Sauerbeck

Laws

Bandaru

et al. 2015

Journal of Neurotrauma

View full text Add to dashboard Cite

show abstract

“…High levels of catecholamines can also lead to overload of intracellular calcium, depletion of adenosine triphosphate, and therefore overproduction of oxygen free radicals and cell injury. Thereafter, a hypotensive phase commences, due to gradual depletion of catecholamines, causing further reduction of the oxygen supply to the internal organs [4,5]. Therefore, it is generally believed that organs should be procured as soon as possible once brain death is confirmed.…”

Section: Introductionmentioning

confidence: 99%

Prolonged Duration of Brain Death was Associated with Better Kidney Allograft Function and Survival: A Prospective Cohort Analysis

et al. 2019

View full text Add to dashboard Cite

BackgroundBrain death initiates hemodynamic, immunological, and hormonal changes that potentially compromise organ quality for transplantation. Therefore, it is generally believed that organs should be procured as soon as possible after the declaration of brain death. However, conflicting data exist regarding the impact of brain death duration on long-term graft function and survival.Material/MethodsThe effect of duration of brain death on graft survival and function of 1869 adult transplant recipients receiving kidneys from deceased donors after brain death was analyzed, using relevant donor and recipient characteristics and allograft related factors.ResultsDuration of brain death was a significant predictor for long-term graft survival, whilst there was no significant effect of duration of brain death on the incidence of delayed graft function or acute graft rejection after kidney transplantation. After dividing the study population into a “short durBD” (<10.6 hours) group and a “long durBD” (>10.6 hours) group, the 15-year graft survival estimates were significantly higher and the serum creatinine at 3 months after transplantation was significantly lower in the “long durBD” group.ConclusionsDuration of brain death does not affect the incidence of delayed graft function or acute rejection after kidney transplantation. However, longer duration of brain death is associated with better kidney allograft function and survival.

show abstract

“…Comparison of the outcomes between organs from living‐related donors and organs from brain dead donors has indicated that brain death has detrimental effects on allograft function . Importantly, most organs are harvested from brain dead donors, and for certain organs, such as cardiac transplants, this is the sole source of donors.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory triggers of acute rejection of organ allografts

Mori

Kreisel

Fullerton

et al. 2014

Immunological Reviews

110

View full text Add to dashboard Cite

Summary Solid organ transplantation is a vital therapy for end stage diseases. Decades of research has established that the components of the adaptive immune system are critical for transplant rejection, but the role of the innate immune system in organ transplantation is just emerging. Accumulating evidence indicates that the innate immune system is activated at the time of organ implantation by the release of endogenous inflammatory triggers. This review discusses the nature of these triggers in organ transplantation and also potential mediators that may enhance inflammation resolution after organ implantation.

show abstract

The influence of brain death on donor liver and the potential mechanisms of protective intervention

Cited by 12 publications

References 49 publications

Spinal Cord Injury Causes Chronic Liver Pathology in Rats

Spinal Cord Injury Causes Chronic Liver Pathology in Rats

Prolonged Duration of Brain Death was Associated with Better Kidney Allograft Function and Survival: A Prospective Cohort Analysis

Inflammatory triggers of acute rejection of organ allografts

Contact Info

Product

Resources

About