The Influence of Arsenic and Certain Other Elements on the Toxicity of Seleniferous Grains

Moxon, A. L.; DuBois, Kenneth P.

doi:10.1093/jn/18.5.447

Cited by 54 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, experiments involving the simultaneous chronic exposure of rats to seleniferous wheat and sodium arsenite in drinking water demonstrated a significant depletion of total selenium in liver by the administered arsenite. 87 In addition, the prolonged exposure of humans to inorganic arsenic in drinking water significantly reduced tissue selenium concentrations. 88 These results, which are most likely based on the in vivo formation and rapid biliary excretion of [(GS) 2 AsSe] À , together with the chemical stability of (GS) 5 (HgSe) core in plasma, 89,90 suggest that the chronic ingestion of inorganic arsenic, mercury and cadmium could cumulatively effect the bioavailability of selenium and result in selenium deficiency (Scheme 1).…”

Section: Discussionmentioning

confidence: 99%

Review: Reactive selenium metabolites as targets of toxic metals/metalloids in mammals: a molecular toxicological perspective

Gailer

2002

Applied Organom Chemis

View full text Add to dashboard Cite

Human activities have been contaminating the environment with toxic heavy metal and metalloid compounds. Since the toxicity of one metal or metalloid can be dramatically modulated by the simultaneous ingestion of another, studies addressing the molecular basis of chemical interactions between toxic and essential elements are increasingly important. The intravenous injection of rabbits with selenite and arsenite or with selenite and mercuric mercury resulted in the in vivo formation of the seleno-bis (S-glutathionyl) arsinium ion, [(GS) 2 AsSe] À , or a glutathione-coated mercuric selenide, (GS) 5 (HgSe) core , in blood. The formation of these species (and the formation of a cadmium±selenium species in blood after the exposure of rats to selenite and cadmium) critically involves reactive selenite metabolites, such as GS±Se À and/or HSe À , which indicates that these physiologically important metabolites are molecular targets of ingested toxic metals and metalloids. The fate and stability of [(GS) 2 AsSe] À and (GS) 5 (HgSe) core in vivo imply that the chronic exposure of mammals to inorganic arsenic and mercury will cumulatively affect the bioavailability of selenium, which could lead to selenium deficiency. Since selenium deficiency is significantly associated with the etiology of cancer in humans, the GSH-driven in vivo formation of selenium-containing metal and metalloid species provides a likely molecular mechanism for the chronic toxicity of environmentally persistent inorganic arsenic, mercury and cadmium.

show abstract

Section: Discussionmentioning

confidence: 99%

Review: Reactive selenium metabolites as targets of toxic metals/metalloids in mammals: a molecular toxicological perspective

Gailer

2002

Applied Organom Chemis

View full text Add to dashboard Cite

show abstract

“…2,3) Selenium (Se) is an essential microelement that negates the toxic effects of several heavy metals, 4) and its toxicological and metabolic interactions with As have been reported in many animal experiments. Moxon and Du Bois 5) revealed the protective effects of As against liver damage and growth depression, both of which are caused by excessive consumption of seleniferous grain, though the mechanisms of protection by Se against As toxicity have not yet been clarified. The experiments of rats injected with 75 Se and As have demonstrated that increase in the As dose markedly increased the amount of 75 Se in the excreted bile, and the increased amount of 75 Se was approximately equivalent to the decreased amount of 75 Se in the liver.…”

Section: Introductionmentioning

confidence: 99%

Negative Correlation between Urinary Selenium and Arsenic Levels of the Residents Living in an Arsenic-Contaminated Area in Bangladesh

Miyazaki

Ushijima

Kadono

et al. 2003

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

Toxicological and metabolic interactions of selenium (Se) with arsenic (As) have been reported in many experimental studies. However, for human populations, possible interactions between As and Se and their toxicological significance have not been established. In this study, we have examined the relationship between Se and As in spot urine samples collected from the inhabitants of two rural communities of northeast Bangladesh. The urinary As (U As ) and Se (U Se ) concentrations were determined by hydride generation atomic absorption spectrometry (HGAAS). Negative correlation between U As and U Se was found in both males and females. Considering the exposure condition in these communities, it is unlikely that the correlation reflected the correlation between the intakes of these elements. This result suggests that As exposure from drinking water or food may change Se metabolism in humans. Possible toxicological significance of the interaction is discussed.

show abstract

“…may underlie their antagonistic behaviour in biological systems (Moxon and DuBois, 1939). The affinity of trivalent arsenic for sulphur is well known (see NAS, 1977 for discussion), and since the involvement of an arsenic cation seems unlikely this can be viewed as an associative pathway analogous to Sn2 displacements in organic chemistry.…”

Section: Figurementioning

confidence: 99%

Metabolism and disposition of inorganic arsenic in laboratory animals and humans

McKinney

1992

Environ Geochem Health

View full text Add to dashboard Cite

The carcinogenicity of inorganic arsenic in humans, particularly in the lung and skin, has been reasonably well established through epidemiological investigations. However, there is no substantial experimental evidence for carcinogenicity in animals to support the human studies. Studies of metabolism and disposition of inorganic arsenic in various animal species are particularly relevant to determining the factors that might account for the lack of an animal model. Numerous studies of this type have been reported, but there do not appear to be clear qualitative or quantitative differences in the overall fate and disposition of inorganic arsenic in most animalsversus humans, although little is known at the cellular and subcellular level.Sulphur chemistry, especially thiol status, is emerging as an important regulating factor in the overall fate and distribution of inorganic arsenic in the body, playing a role in the initial reduction of arsenate to arsenite and subsequent methylation, and possibly in determining tissue affinity and distribution properties. The metabolism of inorganic arsenic can be viewed as a redox cycle in which thiol compounds such as glutathione (GSH) possibly function as reducing agents and methyl donors as oxidising agents. One explanation for the possible sensitivity of certain malnourished human populations to the carcinogenic effects of inorganic arsenic may be related to the reduced availability of nonprotein sulphhydryl compounds such as GSH needed to drive the redox cycle and facilitate arsenic detoxification. Future carcinogenicity studies of inorganic arsenic in animals could be designed to address directly this aspect of the problem.

show abstract

The Influence of Arsenic and Certain Other Elements on the Toxicity of Seleniferous Grains

Cited by 54 publications

References 9 publications

Review: Reactive selenium metabolites as targets of toxic metals/metalloids in mammals: a molecular toxicological perspective

Review: Reactive selenium metabolites as targets of toxic metals/metalloids in mammals: a molecular toxicological perspective

Negative Correlation between Urinary Selenium and Arsenic Levels of the Residents Living in an Arsenic-Contaminated Area in Bangladesh

Metabolism and disposition of inorganic arsenic in laboratory animals and humans

Contact Info

Product

Resources

About