The Influence of Antigen Strength, Agglutinin and Incomplete Antibody on Agglutination by Anti‐D Sera

Renton, P. H.; Hancock, Jeanne A.

doi:10.1111/j.1365-2141.1958.tb03837.x

Cited by 18 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Renton and Hancock [5] showed that when titrating mixtures of incomplete and complete anti-D with Rh(D) positive cells, in creasing the proportion of incomplete to complete anti-D might cause a prozone. It was thought possible that in testing some sera in this series, such a prozone might have escaped detection.…”

Section: Discussionmentioning

confidence: 99%

Saline Anti-Rh(D) and Haemolytic Disease of the Newborn

Hopkins¹

1969

Vox Sanguinis

View full text Add to dashboard Cite

The majority of Rh(D) negative immunised mothers have some sahne agglutinating anti-D in their sera during subsequent pregnancies. This saline antibody is related to a complex effect on the severity of haemolytic disease of the foetus: the stillbirth rate is reduced while the severity of disease among liveborn infants increases slightly with rising titres of saline anti-D. Also, when the observed sahne anti-D titre is 1 the severity of disease is markedly incresed while the protective effect of sahne anti-D on the stillbirth rate fails to operate. The significance of this is discussed. Mothers of group A and especially group B are more liable to form saline anti-D, while the severity of HDN increases if the mother is of group B or AB.

show abstract

Section: Discussionmentioning

confidence: 99%

Saline Anti-Rh(D) and Haemolytic Disease of the Newborn

Hopkins¹

1969

Vox Sanguinis

View full text Add to dashboard Cite

show abstract

“…Its dimensions, as well as the extent of the pro zone and midzone are influenced by the quantitative antigenic con tent of the blood cells. With anti-Rh sera particularly, the range of antiserum concentration encompassing the postzone is also determin ed by the proportion of complete to incomplete antibody [54,58,64]. and the slope are determined only in the postzone; neither parameter is influenced by the extent of the prozone or mid zone except, of course, when these zones extend to or below the 50% level.…”

Section: Factors Influencing the Regression Linementioning

confidence: 99%

Methods in Quantitative Hemagglutination

Solomon¹,

Gibbs²,

Bowdler³

1965

Vox Sanguinis

View full text Add to dashboard Cite

“…Recently Renton and Hancock [12,13] reported on 5 bloods selected from 653 random bloods for their capacity to react in saline suspen sions with incomplete anti-D. These bloods also gave higher scoring values in the blocking reactions with selected sera.…”

mentioning

confidence: 99%