The influence of anesthesia and fluid–structure interaction on simulated shear stress patterns in the carotid bifurcation of mice

Wilde, David De; Trachet, Bram; Meyer, Guido R.Y. De; Segers, Patrick

doi:10.1016/j.jbiomech.2016.06.010

Cited by 23 publications

(19 citation statements)

References 30 publications

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“…The difference in the PSF mainly is that the non-compliant artery wall model yields sharper transitions between low and high permeability regions, where in contrast the compliant artery wall does produce broader and more blurred high permeability regions. Similar observations for the WSS patterns in carotid arteries were observed in [20]. However, in [20] a significant influence of the compliant artery wall to the OSI was observed which lies in contrast to our observations.…”

Section: Discussionsupporting

confidence: 51%

“…Similar observations for the WSS patterns in carotid arteries were observed in [20]. However, in [20] a significant influence of the compliant artery wall to the OSI was observed which lies in contrast to our observations. Still we also support the idea that a FSI-like approach to model atherosclerosis is indispensable.…”

Section: Discussionsupporting

confidence: 51%

“…Still we also support the idea that a FSI-like approach to model atherosclerosis is indispensable. This is also stated by others [58,20,21], but the reason for our conclusion is different. Our observations indicate that not the radial enlargement of the lumen arises the need for a FSI approach, but much more the ability of the model to capture the permanent displacements of the endothelium due to the artery wall thickening.…”

Section: Discussionsupporting

confidence: 46%

“…Iff the direction of growth is constant for all times t, then the incremental growth deformation gradient based formulation, i.e. equations (19) and (20) are equivalent to the representation in equation (13).…”

Section: Growthmentioning

confidence: 99%

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A multiphysics approach for modeling early atherosclerosis

Thon

Hemmler

Glinzer

et al. 2017

Biomech Model Mechanobiol

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This work is devoted to the development of a mathematical model of the early stages of atherosclerosis incorporating processes of all time scales of the disease and to show their interactions. The cardiovascular mechanics is modeled by a fluid-structure interaction approach coupling a non-Newtonian fluid to a hyperelastic solid undergoing anisotropic growth and a change of its constitutive equation. Additionally, the transport of low-density lipoproteins and its penetration through the endothelium is considered by a coupled set of advection-diffusion-reaction equations. Thereby, the permeability of the endothelium is wall-shear stress modulated resulting in a locally varying accumulation of foam cells triggering a novel growth and remodeling formulation. The model is calibrated and applied to an murine-specific case study, and a qualitative validation of the computational results is performed. The model is utilized to further investigate the influence of the pulsatile blood flow and the compliance of the artery wall to the atherosclerotic process. The computational results imply that the pulsatile blood flow is crucial, whereas the compliance of the aorta has only a minor influence on atherosclerosis. Further, it is shown that the novel model is capable to produce a narrowing of the vessel lumen inducing an adaption of the endothelial permeability pattern.

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Section: Discussionsupporting

confidence: 51%

Section: Discussionsupporting

confidence: 51%

Section: Discussionsupporting

confidence: 46%

Section: Growthmentioning

confidence: 99%

See 2 more Smart Citations

A multiphysics approach for modeling early atherosclerosis

Thon

Hemmler

Glinzer

et al. 2017

Biomech Model Mechanobiol

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“…Another limitation pertains to the computational methods that were applied to determine the OSI. Recent work has indicated the importance of the buffering capacity of the carotid bifurcation on the computed OSI level, and they concluded that for accurate OSI computations fluid–structure interaction (FSI) simulations were required [39]. Whether FSI simulations would also influence the OSI values immediately upstream of the cast needs to be investigated.…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress

et al. 2016

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BackgroundWall shear stress (WSS) is involved in the pathophysiology of atherosclerosis. The correlation between WSS and atherosclerosis can be investigated over time using a WSS-manipulated atherosclerotic mouse model. To determine WSS in vivo, detailed 3D geometry of the vessel network is required. However, a protocol to reconstruct 3D murine vasculature using this animal model is lacking. In this project, we evaluated the adequacy of eXIA 160, a small animal contrast agent, for assessing murine vascular network on micro-CT. Also, a protocol was established for vessel geometry segmentation and WSS analysis.MethodsA tapering cast was placed around the right common carotid artery (RCCA) of ApoE−/− mice (n = 8). Contrast-enhanced micro-CT was performed using eXIA 160. An innovative local threshold-based segmentation procedure was implemented to reconstruct 3D geometry of the RCCA. The reconstructed RCCA was compared to the vessel geometry using a global threshold-based segmentation method. Computational fluid dynamics was applied to compute the velocity field and WSS distribution along the RCCA.ResultseXIA 160-enhanced micro-CT allowed clear visualization and assessment of the RCCA in all eight animals. No adverse biological effects were observed from the use of eXIA 160. Segmentation using local threshold values generated more accurate RCCA geometry than the global threshold-based approach. Mouse-specific velocity data and the RCCA geometry generated 3D WSS maps with high resolution, enabling quantitative analysis of WSS. In all animals, we observed low WSS upstream of the cast. Downstream of the cast, asymmetric WSS patterns were revealed with variation in size and location between animals.ConclusionseXIA 160 provided good contrast to reconstruct 3D vessel geometry and determine WSS patterns in the RCCA of the atherosclerotic mouse model. We established a novel local threshold-based segmentation protocol for RCCA reconstruction and WSS computation. The observed differences between animals indicate the necessity to use mouse-specific data for WSS analysis. For our future work, our protocol makes it possible to study in vivo WSS longitudinally over a growing plaque.

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Numerical analysis of the hemodynamics of rat aorta based on magnetic resonance imaging and fluid–structure interaction

Han

Lian

Luo

et al. 2021

Numer Methods Biomed Eng

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Murine models have been widely used to investigate the mechanobiology of aortic atherosclerosis and dissections, which develop preferably at different anatomic locations of aorta. Based MRI and finite element analysis with fluid–structure interaction, we numerically investigated factors that may affect the blood flow and structural mechanics of rat aorta. The results indicated that aortic root motion greatly increases time‐averaged wall shear stress (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), displacement of the aorta, and enhances helical flow pattern but has limited influence on effective stress, which is highly modulated by blood pressure. Moreover, the influence of the motion component on these indicators is different with axial motion more obvious than planar motion. Surrounding fixation of the intercostal arteries and the branch vessels on aortic arch would reduce the influence of aortic root motion. The compliance of the aorta has different influences at different regions, leading to decrease in TAWSS and helical flow, increase in OSI, RRT at the aortic arch, but has reversed effects on the branch vessels. When compared with the steady flow, the pulsatile blood flow would obviously increase the WSS, the displacement, and the effective stress in most regions. In conclusion, to accurately quantify the blood flow and structural mechanics of rat aorta, the motion of the aortic root, the compliance of aortic wall, and the pulsation of blood flow should be considered. However, when only focusing on the effective stress in rat aorta, the motion of the aortic root may be neglected.

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The influence of anesthesia and fluid–structure interaction on simulated shear stress patterns in the carotid bifurcation of mice

Cited by 23 publications

References 30 publications

A multiphysics approach for modeling early atherosclerosis

A multiphysics approach for modeling early atherosclerosis

Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress

Numerical analysis of the hemodynamics of rat aorta based on magnetic resonance imaging and fluid–structure interaction

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