The influence of analogs of xanthine on the mutagenic effect of ultraviolet light

Sideropoulos, Aris S.; Lumb, Judith Rae; Shankel, Delbert M.

doi:10.1007/bf01789136

Cited by 21 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The precise nature of the UV photoproduct for streptomycin resistance mutations became important during our study concerning synergism between the UV induction of this type of mutation and caffeine (25). A rapid decline in the number of potential streptomycin-resistant mutants took place when the UV-irradiated cells were incubated on phosphate-buffered agar (PBA) (24). This study explores the role played by photoproducts of UV light in the loss of potential streptomycin resistance mutations in cells incubated on PBA.…”

mentioning

confidence: 99%

Role of pyrimidine dimer excision in loss of potential streptomycin resistance mutations of ultraviolet-irradiated Escherichia coli on phosphate-buffered agar

Sideropoulos¹,

Greenberg²

1975

J Bacteriol

View full text Add to dashboard Cite

The frequency of ultraviolet (UV)-induced mutations to streptomycin resistance dropped rapidly when starved Escherichia coli strains WP-2 B/r and B/r Twere incubated on phosphate-buffered agar (PBA), but was reduced only slightly in a WP-2 hcrmutant. During postirradiation, incubation viability remained approximately constant. Cells given an optimal recovery treatment with photoreactivating light showed no further recovery if subsequently incubated on PBA. At least 70% of the mutations induced to streptomycin resistance by UV could be repaired. The loss of potential streptomycin-resistant mutants was markedly reduced in strain B/r Twhen 5 ug of acriflavin or 700 ug of caffeine per ml was added to PBA. The excision of UV-induced thymine-containing dimers from E. coli B/r Twas investigated. Dimer excision progressed more slowly when the cells were incubated on PBA containing acriflavin or caffeine. There was no congruity between the kinetics of dimer excision and the kinetics of mutant loss. Our results indicate that removal of potential streptomycin-resistant mutants is considerably faster than the excision of pyrimidine dimers. 1068

show abstract

mentioning

confidence: 99%

Role of pyrimidine dimer excision in loss of potential streptomycin resistance mutations of ultraviolet-irradiated Escherichia coli on phosphate-buffered agar

Sideropoulos¹,

Greenberg²

1975

J Bacteriol

View full text Add to dashboard Cite

show abstract

“…provoquees par le rayonnement U .V. (Witkin 1958, Sideropoulos et Shankel 1968, Mouton et Tremeau 1969, Vizdalova, Jonovska et Zhestjanikov 1971 1969) influence des conditions de croissance (Apelgot 1968)) . Il nous a done paru interessant d'etudier, dans nos experiences, le role de la cafeine, qui, dans le cas de bacteries a radioresistance elevee, reste sans effet sur la survie aux rayons y ou x, mais diminue leur resistance aux rayons u .v .…”

Section: Resultatsunclassified

Variation, en Fonction des Conditions Expérimentales, de l'Efficacité des Désintégrations de³²P Incorporé ChezE. Coli

Apelgot

1972

International Journal of Radiation Biology and Related Studies

View full text Add to dashboard Cite

Les experiences decrites montrent que, pour les bacteries de la souche utilisee, la valeur de a (probabilite d'inactivation de chaque transmutation de 32P incorpore) depend de 1'activite specifique utilisee . A chacune des deux temperatures etudiees (0 et -196°c) it existe deux valeurs de a . La plus grande, as, caracterise les activites specifiques inferieures, et la plus basse, a r , les activites specifiques plus elevees . La concentration correspondant au passage de a g a a r depend de la temperature d'experience et se situe entre 8 et 15 Ci/g P . En ajoutant la D-L-pantoyl-lactone au milieu de croissance, nous avons pu demontrer que ce resultat West pas en relation avec la formation de formes`serpents 'qui apparaissent lorsque la croisssance bacterienne se fait en presence de $ 2 P a activite specifique elevee. En ajoutant la cafeine dans le milieu de post-traitement, au moment du denombrement des bacteries, nous avons pu mettre en evidence l'action de ce compose. Ces resultats demontrent que les bacteries peuvent reparer certaines des lesions produites par les transmutations des atomes de 32P incorpores .

show abstract

“…Escherichia coli. -SIDEROPOULOS et al (1968) have compared the enhancing effect of caffeine on the frequency of UV-induced mutations to streptomycin resistance in E. coli with that of other MOPs, among them theophylline, theobromine, CC and EOC. They found CC to be slightly more and theophylline slightly less active than caffeine, whereas EOC possessed less than half the activity of caffeine.…”

Section: Potentiation Of Uv-induced Mutations Inmentioning

confidence: 99%

Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations

Sturelid¹,

Kihlman²

2009

Hereditas

View full text Add to dashboard Cite

Eight methylated oxypurines were tested for their ability to potentiate the chromosome damage produced by thiotepa and maleic hydrazide in bean (Vicia faba) roots and by thiotepa in Chinese hamster cells. Caffeine was the strongest potentiating agent in Vicia faba roots, 8‐chlorocaffeine in Chinese hamster cells. In both materials tetramethyluric acid was the least active of the methylated oxypurines tested. Caffeine, theobromine and theophylline were effective potentiating agents but poor inducers of exchange‐type aberrations in prophase and the post‐synthetic period of interphase. Tetramethyluric acid, in contrast, was a poor potentiating agent but effective inducer of exchange‐type aberrations. In Vicia faba, post‐treatments with caffeine as potentiating agent reduced by a factor of about 4.5 the concentration of thiotepa required to produce a given aberration frequency.

show abstract

The influence of analogs of xanthine on the mutagenic effect of ultraviolet light

Cited by 21 publications

References 11 publications

Role of pyrimidine dimer excision in loss of potential streptomycin resistance mutations of ultraviolet-irradiated Escherichia coli on phosphate-buffered agar

Role of pyrimidine dimer excision in loss of potential streptomycin resistance mutations of ultraviolet-irradiated Escherichia coli on phosphate-buffered agar

Variation, en Fonction des Conditions Expérimentales, de l'Efficacité des Désintégrations de³²P Incorporé ChezE. Coli

Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations

Contact Info

Product

Resources

About

The influence of analogs of xanthine on the mutagenic effect of ultraviolet light

Cited by 21 publications

References 11 publications

Role of pyrimidine dimer excision in loss of potential streptomycin resistance mutations of ultraviolet-irradiated Escherichia coli on phosphate-buffered agar

Role of pyrimidine dimer excision in loss of potential streptomycin resistance mutations of ultraviolet-irradiated Escherichia coli on phosphate-buffered agar

Variation, en Fonction des Conditions Expérimentales, de l'Efficacité des Désintégrations de32P Incorporé ChezE. Coli

Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations

Contact Info

Product

Resources

About

Variation, en Fonction des Conditions Expérimentales, de l'Efficacité des Désintégrations de³²P Incorporé ChezE. Coli