Abstract:Eight methylated oxypurines were tested for their ability to potentiate the chromosome damage produced by thiotepa and maleic hydrazide in bean (Vicia faba) roots and by thiotepa in Chinese hamster cells. Caffeine was the strongest potentiating agent in Vicia faba roots, 8‐chlorocaffeine in Chinese hamster cells. In both materials tetramethyluric acid was the least active of the methylated oxypurines tested.
Caffeine, theobromine and theophylline were effective potentiating agents but poor inducers of exchange… Show more
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