The influence of aflatoxins on prevalence of neonatal jaundice in Qualyobia Governorate, Egypt

Abstract

flackground: AjlMo.rins(AF) (Ire co111monly environmental toxicnnt in devc/opitJg tropical cottntnes. •Aim of the work: This study set out to im•estigntc tire prevalence of aflato.xins ottd their metabolites in sera of jaundiced neonates and !heir mother's sem aiUI breast milk using Thin Layer Clrroma rograpl!y (TLC). Srtbjects and methods: Samples were obtai11ed from 200 jaundiced neonates and their mothers, and 60 non jaundiced controls and their mothers ndmirred ro Oenfta universiry ltu! pital, locmed in Qual• yobin gm•emorale, Egypt. Results: AF fe1•els in cases were flisMy signiflcam (P<O.OO}} comparins with controls, tfte hishest percentage of aflatoxin type in the suulied groups was forM I. then /112 !lu:n {J I respeclillely bw 110 correlarion be1ween severity of jm111dice wrd ajlatoxitts levels. There was significant negari~>e corre[(ltiatl (P<O.OOI) in birth weightwirh ajlnloxin lel'el in jmmdiced neonates. Tire rates of de• tection of oflmoxins i11 neonates were: significant higher (P<O.OOJ) in breast feeding tha11 !Jollie fadin 0 neonales. signiflcaiH higher (P<O.OOI) i11 fto1 wei than dry cold months a11d significant higher (P<0.05) 111 samples from those living in mralthan ttrban areas. Conclusion: aflato.~ins are risk factor for neonatal jatmdice am/ low birth weigfll in hot wet months in 1hose living i11 rural areas.