The influence of acute ethanol ingestion on phospholipase D activity in rat pancreas

Rydzewska, Grażyna; Jurkowska, Grażyna; Gabryelewicz, A

doi:10.1007/bf02787377

Cited by 4 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PM was detected and showed a significant decrease with alcohol consumption in adults. This finding suggests an apparent decrease in PLD activity in the brain, which is consistent with a previous study that found decreased PLD in rat pancreas from ethanol consumption …”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry

Roux

Jackson

Muller

et al. 2016

ACS Chem. Neurosci.

View full text Add to dashboard Cite

Alcohol abuse is a chronic disease characterized by the consumption of alcohol at a level that interferes with physical and mental health and causes serious and persistent changes in the brain. Lipid metabolism is of particular interest due to its high concentration in the brain. Lipids are the main component of cell membranes, are involved in cell signaling, signal transduction, and energy storage. In this study, we analyzed lipid composition of chronically ethanol exposed mouse brains. Juvenile (JUV) and adult (ADU) mice were placed on a daily limited-access ethanol intake model for 52 days. After euthanasia, brains were harvested, and total lipids were extracted from brain homogenates. Samples were analyzed using high resolution mass spectrometry and processed by multivariate and univariate statistical analysis. Significant lipid changes were observed in different classes including sphingolipids, fatty acids, lysophosphatidylcholines, and other glycerophospholipids.

show abstract

Section: Discussionsupporting

confidence: 93%

“…This finding suggests an apparent decrease in PLD activity in the brain, which is consistent with a previous study that found decreased PLD in rat pancreas from ethanol consumption. 74…”

Section: ■ Conclusionmentioning

confidence: 99%

Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry

Roux

Jackson

Muller

et al. 2016

ACS Chem. Neurosci.

View full text Add to dashboard Cite

show abstract

The Effect of Antecedent Acute Ethanol Ingestion on the Pancreas Ultrastructure in Taurocholate Pancreatitis in Rats

Andrzejewska

Długosz

Jurkowska

1998

Experimental and Molecular Pathology

View full text Add to dashboard Cite

Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis

Hannuksela

Liisanantti

Savolainen

2002

Critical Reviews in Clinical Laboratory Sciences

View full text Add to dashboard Cite

Several studies indicate that light-to-moderate alcohol consumption is associated with a low prevalence of coronary heart disease. An increase in high-density lipoprotein (HDL) cholesterol is associated with alcohol intake and appears to account for approximately half of alcohol's cardioprotective effect. In addition to changes in the concentration and composition of lipoproteins, alcohol consumption may alter the activities of plasma proteins and enzymes involved in lipoprotein metabolism: cholesteryl ester transfer protein, phospholipid transfer protein, lecithin:cholesterol acyltransferase, lipoprotein lipase, hepatic lipase, paraoxonase-1 and phospholipases. Alcohol intake also results in modifications of lipoprotein particles: low sialic acid content in apolipoprotein components of lipoprotein particles (e.g., HDL apo E and apo J) and acetaldehyde modification of apolipoproteins. In addition, "abnormal" lipids, phosphatidylethanol, and fatty acid ethyl esters formed in the presence of ethanol are associated with lipoproteins in plasma. The effects of lipoproteins on the vascular wall cells (endothelial cells, smooth muscle cells, and monocyte/macrophages) may be modulated by ethanol and the alterations further enhanced by modified lipids. The present review discusses the effects of alcohol on lipoproteins in cholesterol transport, as well as the novel effects of lipoproteins on vascular wall cells.

show abstract

The influence of acute ethanol ingestion on phospholipase D activity in rat pancreas

Cited by 4 publications

References 38 publications

Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry

Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry

The Effect of Antecedent Acute Ethanol Ingestion on the Pancreas Ultrastructure in Taurocholate Pancreatitis in Rats

Effect of Alcohol on Lipids and Lipoproteins in Relation to Atherosclerosis

Contact Info

Product

Resources

About