The influence of a humectant‐rich mixture on normalz skin barrier function and on once‐ and twice‐daily treatment of foot xerosis. A prospective, randomized, evaluator–blind, bilateral and untreated‐control study

Lodén, Marie; Scheele, Johan von; Michelson, Sophie

doi:10.1111/srt.12066

Cited by 12 publications

(10 citation statements)

References 34 publications

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“…As shown in this study, the determination of pedal TEWL (below the ankle) is not an appropriate parameter for describing the skin barrier. Similar results were also found by Lodén et al [15] in a study of dry pedal skin. While the tested treatment preparation changed the skin thickness, moisture content and erythema of the feet, no differences were found in this study in terms of the TEWL.…”

Section: Discussionsupporting

confidence: 81%

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The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study

Daehnhardt¹,

Daehnhardt-Pfeiffer²,

Schulte-Walter³

et al. 2016

Skin Pharmacol Physiol

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Background/Aims: Dry skin, or xerosis, is a common condition and a key feature of skin diseases like atopic dermatitis (AD) and ichthyosis vulgaris. Foot xerosis may exist without underlying disease and could be related to very mild forms of AD or ichthyosis vulgaris. The synthesis of important skin lipids (cholesterol, free fatty acids and ceramides) is reduced in xerosis and AD, and reduced lipid synthesis is responsible for a lack of lipids and enzymes in the skin barrier. This slows down reorganisation of the lipid lamellae in the stratum corneum (SC). Methods: Skin barrier integrity was measured by morphometric analysis of the lipid lamellae in the SC after 4 weeks of treatment with a foam cream (active agent vs. placebo). Results: Significant treatment effects were shown after 2 and 4 weeks by an increasing amount of intercellular lipids in the SC. Conclusion: This study shows that a quick reorganisation of the SC lipids initiates a good restoration of the whole skin barrier after 4 weeks of treatment with a foam cream.

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Section: Discussionsupporting

confidence: 81%

“…The proliferation of dry skin increases with advancing age, which is due to changes in the physiological and immunological properties of the skin [14]. Although many people suffering from dry skin of the feet do not have a chronic illness such as diabetes, there are only a few studies regarding pedicure preparations for the foot [15]. …”

Section: Discussionmentioning

confidence: 99%

The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study

Daehnhardt¹,

Daehnhardt-Pfeiffer²,

Schulte-Walter³

et al. 2016

Skin Pharmacol Physiol

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“…In clinical studies on patients with barrier diseases, the visible symptoms of dryness are diminished and the thickness of the hyperkeratotic layer may become normal on treatment with moisturizers . However, the elevated TEWL may not always normalize with the treatment.…”

Section: Preventing or Promoting Dryness And Eczema?mentioning

confidence: 99%

“…Three different patterns regarding TEWL are noted in skin barrier diseases (Fig. ): (i) the elevated TEWL level remains unchanged; (ii) TEWL increases further (i.e. weakening of the barrier); or (iii) TEWL decreases towards normal values (i.e.…”

Section: Preventing or Promoting Dryness And Eczema?mentioning

confidence: 99%

“…For example, treatment of ichthyosis with a urea–lactic acid moisturizer (10% urea in combination with 5% lactic acid) reduced the number of SC layers and improved skin barrier function, whereas a lactic acid–propylene glycol moisturizer further weakened the barrier . Also in hyperkeratotic feet, thinning of the SC by treatment with high concentrations of urea and α‐hydroxy acids was not accompanied by weakening of the skin barrier function …”

Section: Preventing or Promoting Dryness And Eczema?mentioning

confidence: 99%

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Interactions between the stratum corneum and topically applied products: regulatory, instrumental and formulation issues with focus on moisturizers

Lodén¹

2014

Br J Dermatol

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SummaryVirtually everyone in Europe will use at least one cosmetic product every day. The extensive use of cosmetics and results from measurements of quality of life in patients with skin diseases demonstrate the importance of a healthy skin. The skin is not only a barrier against desiccation and intrusion of harmful materials, but also an organ of social communication, where dry, scaly, rough stratum corneum is unappealing to touch, inducing anxiety and depression. Knowledge about the skin biochemistry and the use of noninvasive instruments facilitate the development of topical products and quantification of their effects. The presentation of the products and mode of action determine the regulatory demands and the approval process, as they can fall into different regulatory entities, such as cosmetics, medicinal products, medical devices and as other chemical products. The majority of the topical products on the market are regulated as cosmetics. For example, facial skin care and daily moisturizing routines are frequently used. However, despite visible relief of dryness symptoms, some products are reported to result in deterioration of the skin barrier function. New clinical outcomes show important clinical differences between formulations and the relapse of eczema. In a worst case scenario, treatment with a moisturizing cream may increase the risks of eczema and asthma. In the present overview, product presentations and mode of actions are reflected against the regulatory demands in Europe. The regulations are continuously revisited and new guidelines are being implemented, such as the new cosmetic regulation with advice on testing and responsible marketing.

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Supportive Skin Care in Older Patients

Brandt

Meckfessel²

2015

Advances in Geriatric Dermatology

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The influence of a humectant‐rich mixture on normalz skin barrier function and on once‐ and twice‐daily treatment of foot xerosis. A prospective, randomized, evaluator–blind, bilateral and untreated‐control study

Abstract: The humectant-rich formulation efficiently relieved the xerosis on the feet without inducing any weakening of the skin barrier function. Instead the normal skin became more resistant to external insults by the treatment.

Cited by 12 publications

References 34 publications

The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study

The Influence of Two Different Foam Creams on Skin Barrier Repair of Foot Xerosis: A Prospective, Double-Blind, Randomised, Placebo-Controlled Intra-Individual Study

Interactions between the stratum corneum and topically applied products: regulatory, instrumental and formulation issues with focus on moisturizers

Supportive Skin Care in Older Patients

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