The Infant of the Woman With Gestational Diabetes Mellitus

Uvena-Celebrezze, Jennifer; Catalano, Patrick M.

doi:10.1097/00003081-200003000-00013

Cited by 24 publications

(23 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…About 70% of neonatal macrosomias can be attributed to genetic and constitutional factors, to prolonged pregnancies, or, more rarely, to the presence of particular syndromes such as tumors, nesidioblastosis, and transposition of the large vessels [113]. In about 30% of cases, it occurs in the children of a diabetic mother, with greater frequency in obese and multiparous women [114]. In diabetic pregnancy, macrosomia is typically dysmorphic due to disproportionate and greater growth of the trunk (shoulders and abdomen) with respect to the head.…”

Section: Relationship Between Maternal Modifications Of Carbohydratesmentioning

confidence: 99%

Intermediate metabolism in normal pregnancy and in gestational diabetes

Cianni

Miccoli

Volpe

et al. 2003

Diabetes Metabolism Res

341

279

View full text Add to dashboard Cite

Complex though integrated hormonal and metabolic changes characterize pregnancy. In the face of progressive decline in insulin action, glucose homeostasis is maintained through a compensatory increase in insulin secretion. This switches energy production from carbohydrates to lipids, making glucose readily available to the fetus. This precise and entangled hormonal and metabolic condition can, however, be disrupted and diabetic hyperglycemia can develop (gestational diabetes). The increase in plasma glucose level is believed to confer significant risk of complications to both the mother and the fetus and the newborn. Moreover, exposition of fetal tissues to the diabetic maternal environment can translate into an increased risk for development of diabetes and/or the metabolic syndrome in the adult life. In women with previous gestational diabetes, the risk of developing type 2 diabetes is greatly enhanced, to the point that GDM represents an early stage in the natural history of type 2 diabetes. In these women, accurate follow-up and prevention strategies are needed to reduce the subsequent development of overt diabetes. This paper will review current knowledge on the modifications occurring in normal pregnancy, while outlining the mechanisms. In this paper, we will review the changes of intermediary metabolism occurring during pregnancy. In particular, we will outline the mechanisms responsible for gestational diabetes; the link between these alterations and associated maternal and neonatal morbidity will be examined.

show abstract

Section: Relationship Between Maternal Modifications Of Carbohydratesmentioning

confidence: 99%

Intermediate metabolism in normal pregnancy and in gestational diabetes

Cianni

Miccoli

Volpe

et al. 2003

Diabetes Metabolism Res

341

279

View full text Add to dashboard Cite

show abstract

“…Survenant habituellement dans 0,2 à 2,8 % des naissances, elle atteint 3 à 9 % des patientes présentant un DG. Ce taux atteint 14 à 25 % en cas de DG associé à un poids foetal de plus de 4000 g, et même près de 50 % des patientes si le poids foetal atteint ou dépasse 4500 g [11][12][13][14]. Cette augmentation des taux de dystocie s'explique par le fait que la macrosomie touche les tissus sensibles à l'insuline (essentiellement les tissus mous), se traduisant par une disproportion entre le diamètre du bassin maternel et les diamètres foetaux programmés génétiquement (circonfé-rence abdominale, diamètre biacromial).…”

Section: Quels Sont Les Risques Foetaux Liés Au Diabète Gestationnel ?unclassified

“…Les enfants nés de mères présentant un DG présentent, par ailleurs, un risque d'hypoglycémie, d'hyperbilirubinémie et d'hypocalcémie élevé par rapport aux enfants nés de mères non diabétiques [12]. En cas de DG, il existe également une augmentation du risque de détresse respiratoire néonatale.…”

Section: Quels Sont Les Risques Foetaux Liés Au Diabète Gestationnel ?unclassified

Quinze questions pratiques concernant le diabète gestationnel

Clay

Deruelle

Fischer

et al. 2007

Gynécologie Obstétrique & Fertilité

View full text Add to dashboard Cite

“…Em gestações complicadas pelo diabete melito são descritas alterações do sistema cardiovascular fetal em que se verifi ca aumento da espessura das paredes ventriculares e do septo interventricular [13][14][15] e também a cardiomegalia 2,16,17 . A causa da taxa de crescimento cardíaco anormal não está clara, mas pode-se relatar diferença no grau de sensibilidade do miocárdio fetal a fatores de crescimento gerados pela mãe 17 , placenta ou feto em resposta à estimulação hiperglicemiante 18 .…”

Section: Discussionunclassified

Freqüência cardíaca fetal e doplervelocimetria das artérias umbilicais entre a 18ª e a 20ª semana de gestação em pacientes com diabete melito pré-gestacional

Nomura¹,

Teshima²,

Martins³

et al. 2006

Rev. Bras. Ginecol. Obstet.

View full text Add to dashboard Cite

Freqüência cardíaca fetal e doplervelocimetria das artérias umbilicais entre a 18ª e a 20ª semana de gestação em pacientes com diabete melito pré-gestacionalFetal heart rate and umbilical artery Dopplervelocimetry between the 18th and 20th weeks of gestation in pregnancies complicated by pregestational diabetes mellitus ABSTRACT Purpose: to analyze the fetal heart rate (FHR) and umbilical artery Dopplervelocimetry between 18th and 20th weeks of gestation in pregnant women complicated by pregestational diabetes mellitus. Methods: twenty-eight pregnancies with pregestational diabetes and 27 normal pregnant women were analyzed prospectively, in a cross-sectional and case-control study. The inclusion criteria were the following: singleton pregnancy between 18 and 29 weeks, no other associated maternal diseases and no fetal abnormality. Ultrasonography was performed and FHR was calculated by the interval between the beginnings of two consecutive cardiac cycles, in the three umbilical artery Doppler sonograms, obtained in the umbilical

show abstract

The Infant of the Woman With Gestational Diabetes Mellitus

Cited by 24 publications

References 68 publications

Intermediate metabolism in normal pregnancy and in gestational diabetes

Intermediate metabolism in normal pregnancy and in gestational diabetes

Quinze questions pratiques concernant le diabète gestationnel

Freqüência cardíaca fetal e doplervelocimetria das artérias umbilicais entre a 18ª e a 20ª semana de gestação em pacientes com diabete melito pré-gestacional

Contact Info

Product

Resources

About