The Induction of the L. E. Cell (Hargraves) in Normal Peripheral Blood*

Moffatt, Thomas W.; Barnes, Seth S.; Weiss, Richard

doi:10.1038/jid.1950.20

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1950

1965

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Cited by 21 publications

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Studies on the L. E. Phenomenon

Barnes¹

1950

Arch Dermatol

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Studies on the L. E. Phenomenon

Barnes¹

1950

Arch Dermatol

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Simplified Method for the L. E. Cell Test

Dubois¹

1953

AMA Arch Intern Med

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THE DESCRIPTION by Hargraves of the L. E. cell five years ago gave a great impetus to the study of systemic lupus erythematosus.1 The frequency of the disease and the variability of its clinical picture have since been emphasized by numerous workers using the L. E. test to verify their diagnosis. It is the purpose of this paper to present a simplified technique for the production of L. E. cell preparations which has been in use at the Los Angeles County General Hospital for three years and to compare its results with others in general use. In my experience the test is pathognomonic if positive.2 Since we began utilizing this method, the diagnosis of lupus has increased four-fold at this hospital. Negative preparations occur in 30% of typical clinical cases of systemic lupus erythematosus.2d Our experience with this technique in a series of 72 cases of lupus erythematosus will also be reviewed. MATERIALS AND METHODSSeven hundred tests on persons with all types of diseases were performed, with particular emphasis on patients who might have a variant of systemic lupus erythematosus (Table 1). With the combined use of the test and clinical study, 72 new cases of systemic lupus erythe¬ matosus were discovered and 380 tests were performed in these cases alone. Below is given an outline of the technique which we have employed during the past three years.1. Add two drops of aqueous heparin solution (50 mg. per cubic centimeter) to a 15 cc. test tube. 2. Place 10 cc. of venous blood or several cubic centimeters of bone marrow in the tube and shake well.3. Allow tube to remain at room temperature 30 to 60 minutes.

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Plasma L. E. Test in Systemic Lupus Erythematosus

Haserick¹

1951

JAMA

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The Induction of the L. E. Cell (Hargraves) in Normal Peripheral Blood*

Cited by 21 publications

References 3 publications

Studies on the L. E. Phenomenon

Studies on the L. E. Phenomenon

Simplified Method for the L. E. Cell Test

Plasma L. E. Test in Systemic Lupus Erythematosus

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