The induction of taxol production in the endophytic fungus-- Periconia sp from Torreya grandifolia

Li, J Y; Sidhu, Rajinder S.; Ford, Eugene; Long, David M.; Hess, W. M.; Strobel, Gary A.

doi:10.1038/sj.jim.2900521

Cited by 154 publications

(69 citation statements)

References 13 publications

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“…was isolated from Torreya grandifolia (China), a relative of yews, but not a source of paclitaxel. 36 Fungal endophytes isolated from other plants were also reported as paclitaxel producers. Seimatoantlerium tepuiense was isolated from Maguireothamnus speciosus an endemic plant of the Southwest of Venezuela.…”

Section: Paclitaxel-producing Microorganismsmentioning

confidence: 99%

Microbial paclitaxel: advances and perspectives

et al. 2010

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Paclitaxel is a potent and widely used antitumor agent. Considerable worldwide research efforts have been carried out on different production alternatives. Since the description of the first paclitaxel-producing fungi, more than 15 years ago, microorganisms have been investigated as potential alternatives for an environmentally acceptable, relatively simple and inexpensive method to produce paclitaxel. However, in spite of significant research on paclitaxel-producing microorganisms, no commercial fermentation process has been implemented up to now. The aim of this study is to review the present status of research on paclitaxel-producing microorganisms and the ongoing efforts to develop heterologous paclitaxel biosynthesis, and analyze the perspectives of microbial fermentation for paclitaxel production.

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Section: Paclitaxel-producing Microorganismsmentioning

confidence: 99%

Microbial paclitaxel: advances and perspectives

et al. 2010

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“…Torreya grandifolia [256] Pestalotia bicilia T. baccata [217] Pestalotia pauciseta Cardiospermum helicacabum Tabebuia pentaphylla…”

Section: Taxus Yunnanensis (=T Wallichiana) T Globosa T Chinensis mentioning

confidence: 99%

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

2015

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Abstract:It is known that plant-based ethnomedicine represented the foundation of modern pharmacology and that many pharmaceuticals are derived from compounds occurring in plant extracts. This track still stimulates a worldwide investigational activity aimed at identifying novel bioactive products of plant origin. However, the discovery that endophytic fungi are able to produce many plant-derived drugs has disclosed new horizons for their availability and production on a large scale by the pharmaceutical industry. In fact, following the path traced by the blockbuster drug taxol, an increasing number of valuable compounds originally characterized as secondary metabolites of plant species belonging to the Spermatophyta have been reported as fermentation products of endophytic fungal strains. Aspects concerning sources and bioactive properties of these compounds are reviewed in this paper.

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“…Members of Periconia have a very wide host range as an endophyte and have been reported from several other pharmaceutically important plants, such as Azadirachta indica, 33 Eucalyptus citriodora, 44 Torriya grandifolia etc. 45 The SEM study of this strain showed very prominent characteristic long conidiophores, dark, long, stout and shortly branched near the apex, bearing attached groups of conidiogenous cells at their tips (Figures 1a and b). As the chains of conidia are very fragile, only a few conidia are visibly attached on conidiogenous cells (Figure 1b), which is why the environmental SEM was performed to scan the head of conidiophores with attached conidia (Figure 1d).…”

Section: Resultsmentioning

confidence: 99%

“…isolated from Torriya grandifolia was also reported to produce taxol, 45 thus it seems that member of this genus would be well worth considering in 'bio-prospecting' for novel pharmaceuticals. However, the ability of endophytes to produce these chemicals raises several intriguing questions that have yet to be answered, including, whether the compound is first synthesized by the plant or by the fungus and whether there is a transfer of genetic information between the two.…”

Section: Resultsmentioning

confidence: 99%

Piperine production by endophytic fungus Periconia sp. Isolated from Piper longum L.

et al. 2011

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The endophytic fungus Periconia sp. produces piperine (5-(3, 4-methylenedioxyphenyl)-1-piperidinopent-2, 4-dien-1-one) under liquid culture. This is the first report of the alternative source for this chemical other than its host, Piper longum. The highly functionalized fungus-derived piperine exhibits strong antimycobacterial activity against Mycobacterium tuberculosis and M. smegmetis with minimum inhibitory concentrations of 1.74 and 2.62 lg ml À1 , respectively. The compound was crystallized and the structure was elucidated by single-crystal X-ray crystallography. This finding is of significance as piperine is a potential cancer preventative agent. It is reaffirmed by this report that important pharmaceuticals can be produced by endophytic microbes, and these molecules appear to be mimetic to their host origin. Therefore, we can enhance the bioactive principles of medicinal plants by isolating and identifying the endophytes, thereby showing the importance of preserving the biodiversity of these plants.

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The induction of taxol production in the endophytic fungus-- Periconia sp from Torreya grandifolia

Cited by 154 publications

References 13 publications

Microbial paclitaxel: advances and perspectives

Microbial paclitaxel: advances and perspectives

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

Piperine production by endophytic fungus Periconia sp. Isolated from Piper longum L.

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