The induction of CD80 and apoptosis on B cells and CD40L in CD4+ T cells in response to seasonal influenza vaccination distinguishes responders versus non-responders in healthy controls and aviremic ART-treated HIV-infected individuals
Abstract:Background
Studies have shown that HIV infection is associated with an impaired influenza vaccine response. We examined the role of cellular phenotypes and function in influenza vaccine responsiveness in healthy controls and aviremic HIV-infected subjects on antiretroviral treatment (ART).
Methods
16 healthy controls and 26 ART+ aviremic HIV+ subjects were enrolled in the current study. Blood was collected at pre-vaccination (D0), and on days 7–10 (D7) and 14–21 (D14) following the 2013–2014 seasonal influen… Show more
“…7a ). HLA-DR + CD80 + expression had been proved to be a key factor affecting the B-cell antigen presentation 39 . In the deceased patients, the HLA-DR expression on total B cells, MBs, MZ B and CD27 − IgD − B cells was significantly more down-regulated than that in the survived patients in the 3rd week (Fig.…”
Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-viral immune response has been reported, but humoral involvement in viral pathogenesis is poorly understood. Here we show defective serological responses to SFTSV is associated with disease fatality and a combination of B-cell and T-cell impairment contribute to disruption of anti-viral immunity. The serological profile in deceased patients is characterized by absence of specific IgG to viral nucleocapsid and glycoprotein due to failure of B-cell class switching. Expansion and impairment of antibody secretion is a signature of fatal SFTSV infection. Apoptosis of monocytes in the early stage of infection diminishes antigen-presentation by dendritic cells, impedes differentiation and function of T follicular helper cells, and contributes to failure of the virus-specific humoral response.
“…7a ). HLA-DR + CD80 + expression had been proved to be a key factor affecting the B-cell antigen presentation 39 . In the deceased patients, the HLA-DR expression on total B cells, MBs, MZ B and CD27 − IgD − B cells was significantly more down-regulated than that in the survived patients in the 3rd week (Fig.…”
Severe Fever with Thrombocytopenia Syndrome (SFTS), an emerging infectious disease caused by a novel phlebovirus, is associated with high fatality. Therapeutic interventions are lacking and disease pathogenesis is yet to be fully elucidated. The anti-viral immune response has been reported, but humoral involvement in viral pathogenesis is poorly understood. Here we show defective serological responses to SFTSV is associated with disease fatality and a combination of B-cell and T-cell impairment contribute to disruption of anti-viral immunity. The serological profile in deceased patients is characterized by absence of specific IgG to viral nucleocapsid and glycoprotein due to failure of B-cell class switching. Expansion and impairment of antibody secretion is a signature of fatal SFTSV infection. Apoptosis of monocytes in the early stage of infection diminishes antigen-presentation by dendritic cells, impedes differentiation and function of T follicular helper cells, and contributes to failure of the virus-specific humoral response.
“…No impact on CD4+ cell counts or viral load was observed [30]. Powell et al assessed T-cell responses to influenza A/California/7/2009 vaccine in HIV-infected and healthy individuals [31]. Reduced CD4+ and CD8+ cell responses were observed in people living with HIV, indicating potential challenges in cell-mediated immunity [31].…”
Section: Vaccinations Against Respiratory Pathogens 21 Vaccinations A...mentioning
confidence: 99%
“…Powell et al assessed T-cell responses to influenza A/California/7/2009 vaccine in HIV-infected and healthy individuals [31]. Reduced CD4+ and CD8+ cell responses were observed in people living with HIV, indicating potential challenges in cell-mediated immunity [31]. Pallikkuth et al investigated mechanisms influencing antibody response to nonadjuvanted 2009 H1N1 influenza vaccine in HIV-infected individuals [32].…”
Section: Vaccinations Against Respiratory Pathogens 21 Vaccinations A...mentioning
People living with human immunodeficiency virus (HIV) are at higher risk of morbidity and mortality due to vaccine-preventable diseases. At the same time, they are less likely to respond to vaccinations, and might have a higher rate of vaccine adverse event and faster waning of protective effect. International and national guidelines emphasize the importance of vaccinating people living with HIV against respiratory system disease pathogens including seasonal influenza, Streptococcus pneumoniae, and COVID-19, as well as against sexually transmitted infections, i.e., Hepatitis A and B (HAV, HBV) and human papillomavirus (HPV). This narrative review aims to provide a comprehensive examination of the current knowledge regarding the immune and clinical responses elicited by vaccinations in the older adult population living with HIV.
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