Analysis of protective immune responses to seasonal influenza vaccination in HIV-infected individuals

Xia, Ying; Mi, Fuli; Du, Guiqiang; Qin, Shenghui

doi:10.1080/21645515.2020.1754701

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complications of the influenza virus make the need for the annual vaccination of people living with HIV/AIDS imperative, and these complications are accompanied by high rates of morbidity and mortality [4].…”

Section: Influenza Virus Vaccinationmentioning

confidence: 99%

“…Vaccination against other diseases is usually recommended for people with HIV/AIDS infection. Vaccination against seasonal influenza, pneumococcus, human papillomavirus (HPV), hepatitis A virus (HAV) and hepatitis B virus (HBV), herpes zoster or shingles, and the latest SARS-CoV-2 infection, is recommended or even imposed on people with HIV infection [4,5] It is vital specific assessments be required based on strict scientific criteria such as the prevalence of the disease, as well as the examination of possible complications by age group or based on underlying diseases, before any vaccine being widely used in humans [6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

HIV infection and vaccinations

Ouzounakis¹,

Frantzana²,

Iliadis³

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

Introduction: Vaccination is mentioned as a most successful way of intervention in public health. Vaccination against other diseases is usually recommended for people with Human Immunodeficiency Virus (HIV/AIDS) infection. Purpose: To identify the correlation of vaccines and vaccination in patients suffering from HIV/AIDS infection. Methodology: This narrative review was based on the bibliographic search of reviews and research studies drawn from the international databases. The exclusion criterion of the articles was the language other than English and Greek. Results: HIV infection is characterized by severe immunodeficiency, which is the result of a decrease in the number of CD4+ T – lymphocytes. The right time to vaccinate a HIV patient is not precisely determined, but it is recommended for those with low CD4 values. All HIV patients are recommended to be vaccinated the annual vaccination of Influenza virus vaccination. It also is recommended to be vaccinated with the vaccination against human papillomavirus (HPV), the vaccination against hepatitis A virus (HAV) and hepatitis B virus (HBV), the vaccination against herpes zoster or shingles and the vaccination against COVID-19 infection. Conclusion: People with HIV/AIDS are more vulnerable to infections from various diseases. Therefore, it is necessary patients with HIV infection be vaccinated against life-threatening diseases.

show abstract

Section: Influenza Virus Vaccinationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HIV infection and vaccinations

Ouzounakis¹,

Frantzana²,

Iliadis³

et al. 2023

World J. Adv. Res. Rev.

View full text Add to dashboard Cite

show abstract

Machine Learning Revealed a Novel Ferroptosis-Based Classification for Diagnosis in Antiretroviral Therapy-Treated HIV Patients with Defective Immune Recovery

Huang

2024

AIDS Research and Human Retroviruses

View full text Add to dashboard Cite

Limited Humoral and Specific T-Cell Responses After SARS-CoV-2 Vaccination in PWH With Poor Immune Reconstitution

Benet

Blanch-Lombarte

Ainsua-Enrich

et al. 2022

The Journal of Infectious Diseases

View full text Add to dashboard Cite

Background We analyzed humoral and cellular immune responses induced by SARS-CoV-2 mRNA vaccines in people living with HIV-1 (PLWH) with < 200 CD4+ T-cells. Methods Prospective cohort study including 58 PLWH with CD4+ T-cell counts <200 cells/mm3, 36 with CD4+ T-cell counts >500, and 33 HIV-1-negative controls. Antibodies against the SARS-CoV-2 Spike protein (anti-S IgG) and the receptor-binding domain (anti-RBD IgG) were quantified before and four weeks after the first and the second dose of BNT162b2 or mRNA-1273 (w8). Viral neutralization activity and T-cell responses were also determined. Results At w8, anti-S/anti-RBD IgG responses increased in all groups (P < 0.0001). Median (IQR) S-IgG and RBD-IgG at w8 were 153.6 (26.4; 654.9) and 171.9 (61.8; 425.8) in the HIV < 200 group compared to 245.6 (145; 824) and 555.8 (166.4; 1751) in the HIV > 500 group, and 274.7 (193.7; 680.4) and 281.6 (181; 831.8) BAU/mL in controls (P < 0.05). Neutralizing capacity and specific T-cell immune responses were absent or reduced in 33% of the HIV < 200 group, compared with 3.7% in the HIV > 500 (P = 0.0003). Conclusion One third of PLWH with CD4+ T-cell counts <200 cells/mm3 show low anti-S/anti-RBD IgG levels, reduced in vitro neutralization activity against SARS-CoV-2 and no vaccine-induced T-cells after receiving COVID-19 mRNA vaccines.

show abstract

Analysis of protective immune responses to seasonal influenza vaccination in HIV-infected individuals

Cited by 3 publications

References 37 publications

HIV infection and vaccinations

HIV infection and vaccinations

Machine Learning Revealed a Novel Ferroptosis-Based Classification for Diagnosis in Antiretroviral Therapy-Treated HIV Patients with Defective Immune Recovery

Limited Humoral and Specific T-Cell Responses After SARS-CoV-2 Vaccination in PWH With Poor Immune Reconstitution

Contact Info

Product

Resources

About