The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens

Hartaningsih, Nining; Dharma, D.M.N.; Soeharsono, S.; Wilcox, G. E.

doi:10.1016/s0165-2427(00)00265-8

Cited by 11 publications

(20 citation statements)

References 12 publications

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“…Viruses were inactivated either by formaldehyde or Triton X-100. Two adjuvants were tested: Incomplete Freund's Adjuvant (IFA) or a Mineral Oil Adjuvant (MOA) and the vaccine preparation was emulsified to form a homogenous suspension (Hartaningsih et al, 2001).…”

Section: Sources Of Virus Methods Of Preparation and Adjuvantsmentioning

confidence: 99%

“…Examination of gross and histopathological lesions of Jembrana disease was also performed at the conclusion of the observation period. Humoral response was established by serological assays, using Western blotting (Hartaningsih et al, 2001).…”

Section: Modes Of Vaccine Delivery and Challengementioning

confidence: 99%

“…Vaccination with formaldehyde-inactivated viruses also induced the production of JDV-specific antibodies though at markedly lower level but the vaccinated animals still developed clinical and haematological changes typical to Jembrana disease. It appeared so that Triton X-100-inactivated viral particles gave more satisfying result although the protective effect of the vaccine was not complete (Hartaningsih et al, 2001).…”

Section: Inactivating Agentmentioning

confidence: 99%

“…For lack of efficient medical treatment of JDV-infected cattle, vaccination may therefore constitute an effective measure for the prevention or eradication of Jembrana disease. Up to date, only one type of vaccine has been reported and tested Hartaningsih et al, 2001). It is based on inactivated, tissue-derived virus antigens (Tabanan/87 isolate, JDV TAB/87 ) Hartaningsih et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Up to date, only one type of vaccine has been reported and tested Hartaningsih et al, 2001). It is based on inactivated, tissue-derived virus antigens (Tabanan/87 isolate, JDV TAB/87 ) Hartaningsih et al, 2001). Presently, the vaccine is commercially available (JDVacc) and is routinely used for controlling the spread of Jembrana disease .…”

Section: Introductionmentioning

confidence: 99%

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Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Kusumawati¹,

Wanahari²,

Astuti³

et al. 2015

American Journal of Immunology

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Jembrana disease constitutes the main concern in cattle industry especially in Indonesia and Australia as it has caused important economic losses due to mortality of cattle. The pathology of the disease is unusual for a lentivirus infection as it is associated with a severe, often lethal disease syndrome and a short incubation period in cattle. For lack of efficient medical treatment of JDV-infected cattle, vaccination may therefore constitute an effective measure for the prevention or eradication of Jembrana disease. Up to date, only one type of vaccine has been reported and tested. It is based on inactivated, tissue-derived virus antigens (Tabanan/87 isolate, JDV TAB/87 ). This review summarize show current Jembrana disease vaccine was developed as well as evaluated and how these information might be useful in future vaccine design.

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Section: Sources Of Virus Methods Of Preparation and Adjuvantsmentioning

confidence: 99%

Section: Modes Of Vaccine Delivery and Challengementioning

confidence: 99%

Section: Inactivating Agentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Kusumawati¹,

Wanahari²,

Astuti³

et al. 2015

American Journal of Immunology

View full text Add to dashboard Cite

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Analysis of Jembrana disease virus replication dynamics in vivo reveals strain variation and atypical responses to infection

et al. 2009

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Jembrana disease virus (JDV) is an acute lentiviral infection of Bali cattle in Indonesia. Data generated during a series of cattle infection experiments was examined and significant differences were identified in the mean plasma viral load on the first and second days of the febrile response in cattle infected with JDV(TAB/87) compared to those infected with JDV(PUL/01). The peak and total viral loads >or=10(6) genome copies/ml during the acute stage of the disease were significantly higher in JDV(TAB/87) infected cattle. JDV(PUL/01) infected cattle developed peak rectal temperatures earlier than the JDV(TAB/87) cattle but there were no differences in the duration of the febrile responses observed for the 2 groups of animals. The plasma viremia was above 10(6) genome copies/ml for almost 3 days longer in JDV(TAB/87) compared to JDV(PUL/01) infected cattle. Atypical responses to infection occurred in approximately 15% of experimentally infected animals, characterized by reduced viral loads, lower or absent febrile responses and absence of p26-specific antibody responses. Most of these cattle developed normal Tm-specific antibody responses between 4-12 weeks post-infection.

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Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle

et al. 2009

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The efficacy of a tissue-derived vaccine, which is currently used in Indonesia to control the spread of Jembrana disease in Bali cattle, was determined by quantifying the viral load in plasma following experimental infection with Jembrana disease virus. Virus transmission is most likely to occur during the acute phase of infection when viral titers are greater than 10(6) genomes/ml. Vaccinated cattle were found to have a 96% reduction in viral load above this threshold compared to control cattle. This would reduce the chance of virus transmission as the number of days above the threshold in the vaccinated cattle was reduced by 33%. Viral loads at the onset and resolution of fever were significantly lower in the vaccinated cattle and immune function was maintained with the development of antibody responses to Env proteins within 10-24 days post challenge. There was, however, no significant reduction in the duration of the febrile period in vaccinated animals. The duration and severity of clinical parameters were found to be variable within each group of cattle but the quantification of viral load revealed the benefits of vaccinating to reduce the risk of virus transmission as well as to ameliorate disease.

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The induction of a protective immunity against Jembrana disease in cattle by vaccination with inactivated tissue-derived virus antigens

Cited by 11 publications

References 12 publications

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Vaccine against Jembrana Disease Virus Infection: A Summary Findings

Analysis of Jembrana disease virus replication dynamics in vivo reveals strain variation and atypical responses to infection

Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle

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