The increasing problem of hepatitis C virus infection

Coates, E. O.; Walsh, L. J.; Logan, Richard M.

doi:10.1111/j.1834-7819.2001.tb00268.x

Cited by 8 publications

(8 citation statements)

References 26 publications

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“…Poor oral health has been reported in HCV-infected patients [33][34][35][36]. Coates et al reported that the experience of dental caries was significantly worse in HCVinfected subjects than in patients in general [33].…”

Section: Discussionmentioning

confidence: 99%

Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases

2012

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BackgroundOral lichen planus (OLP) is seen frequently in patients with hepatitis C virus (HCV) infection. The aim of this study was to evaluate the occurrence of oral candidiasis, other mucosal lesions, and xerostomia during interferon (IFN) therapy for HCV infection.MethodsOf 124 patients with HCV-infected liver diseases treated with IFN therapy in our hospital, 14 (mean age 56.00 ± 12.94 years) who attended to receive administration of IFN once a week were identified and examined for Candida infection and other oral lesions and for the measurement of salivary flow. Serological assays also were carried out.ResultsCultures of Candida from the tongue surfaces were positive in 7 (50.0%) of the 14 patients with HCV infection at least once during IFN therapy. C. albicans was the most common species isolated. The incidence of Candida during treatment with IFN did not increase above that before treatment. Additional oral mucosal lesions were observed in 50.0% (7/14) of patients: OLP in three (21.4%), angular cheilitis in three (21.4%) and recurrent aphthous stomatitis in one (7.1%). OLP occurred in one patient before treatment with IFN, in one during treatment and in one at the end of treatment. 85.7% of the oral lesions were treated with topical steroids. We compared the characteristics of the 7 patients in whom Candida was detected at least once during IFN therapy (group 1) and the 7 patients in whom Candida was not detected during IFN therapy (group 2). The prevalence of oral mucosal lesions (P=0.0075) and incidence of external use of steroids (P=0.0308) in group 1 were significantly higher than in group 2. The average body weight of group 1 decreased significantly compared to group 2 (P=0.0088). Salivary flow decreased in all subjects throughout the course of IFN treatment and returned at 6th months after the end of treatment. In group 1, the level of albumin at the beginning of the 6th month of IFN administration was lower than in group 2 (P=0.0550). According to multivariate analysis, one factor, the presence of oral mucosal lesions, was associated with the detection of Candida. The adjusted odds ratio for the factor was 36.00 (95% confidence interval 2.68-1485.94).ConclusionWe should pay more attention to oral candidiasis as well as other oral mucosal lesions, in patients with weight loss during IFN treatment.

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Section: Discussionmentioning

confidence: 99%

Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases

2012

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“…Some patients had decreased sensitivity of taste despite the fact that they were unaware of their taste disorder. In addition, poor oral health has been reported for HCV-infected patients [16][17][18][19]. In our previous study, dental problems delayed the initiation of IFN therapy for a maximum of 105 days [7].…”

Section: Discussionmentioning

confidence: 91%

Effect of oral care gel on the quality of life for oral lichen planus in patients with chronic HCV infection

Nagao

Sata

2011

Virol J

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BackgroundOral lichen planus (OLP) decreases the quality of life because it can cause spontaneous pain during eating and tooth-brushing and an uncomfortable feeling in the mouth. In addition, OLP may be associated with HCV-related liver disease.We investigated the visual analogue scale (VAS) and effects of oral care gel, REFRECARE-H®, on patients with OLP associated with HCV infection.ResultsNine OLP patients (mean age 67.9 ± 7.6 years) with HCV-related liver diseases were recruited and their VAS score determined along with a biochemical examination of the blood. Types of OLP included erosive (6 patients) and reticular (3). REFRECARE-H®, an oral care gel (therapeutic dentifrice) containing hinokitiol, was applied by each patient as a thin layer on the oral membrane, after each meal and at bedtime for 30 days. Application of REFRECARE-H® improved the quality of life in all terms of dry mouth, breath odor, oral freshness, oral pain during rest, oral pain at a mealtimes, taste disorder, loss of appetite, sleep disorder, depressive mood and jitteriness. VAS scores of dry mouth, breath odor, oral freshness, and sleep disorder were significantly increased 30 days after application of REFRECARE-H® (P = 0.01, P = 0.05, P = 0.03, P = 0.04). VAS scores of oral pain at a mealtimes and taste disorder were increased 30 days after application of REFRECARE-H® (P = 0.06). There was an absence of side effects.ConclusionsREFRECARE-H® improved the quality of life for OLP. It is necessary for the hepatologist to educate patients regarding oral hygiene, as well as provide treatment of liver disease.

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“…probable increased risk of developing periodontal disease associated with a diabetes-induced inflammatory response) or indirectly (probable increased risk of dental caries in HCV-infected patients by decreased salivary flow due to prescribed medications). [2223]…”

Section: Oral Healthmentioning

confidence: 99%

Oral conditions associated with Hepatitis C virus infection

Alavian

Mahboobi

et al. 2013

Saudi J Gastroenterol

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Hepatitis C virus (HCV) infection in more than 170 million chronically infected patients with no developed preventive vaccine is a globally important issue. In addition to expected hepatic manifestations, a number of extrahepatic manifestations, such as mixed cryoglobulinemia, glomerulonephritis, polyarteritis nodosa, rashes, renal disease, neuropathy, and lymphoma, have been reported following HCV infection, which are believed to be influenced by the virus or the host immune response. HCV combination therapy with pegylated interferon and ribavirin might be associated with side effects as well. The association of HCV with special oral conditions has also been reported recurrently; the mechanism of most of which remains unclear. This article reviews the association of HCV infection with some of the oral conditions such as oral health, Sjogren's syndrome, lichen planus and oral cancer.

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The increasing problem of hepatitis C virus infection

Cited by 8 publications

References 26 publications

Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases

Candidiasis and other oral mucosal lesions during and after interferon therapy for HCV-related chronic liver diseases

Effect of oral care gel on the quality of life for oral lichen planus in patients with chronic HCV infection

Oral conditions associated with Hepatitis C virus infection

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