Oral conditions associated with Hepatitis C virus infection

Alavian, Seyed Moayed; Mahboobi, Nastaran; Mahboobi, Nima; Karayiannis, Peter

doi:10.4103/1319-3767.121032

Cited by 24 publications

(22 citation statements)

References 59 publications

(86 reference statements)

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“…Hepatitis C is generally asymptomatic with up to 80% of infected cases which will progress to persistent infection. About 15-20% of chronic HCV infection progressed to cirrhosis and 1 to 4% are found to be an annual risk of developing hepatocellular carcinoma within 20-30 years [1][2][3]. Blood, blood-products and intravenous drug abuse (IV) are related with the transmission of this virus.…”

Section: Introductionmentioning

confidence: 99%

“…Surprisingly, Nokhodian and his colleagues (2012) stated that HCV transmission may also be acquired through non-parenteral and non-sexual routes [6]. Indeed, several authors estimated that up to 40% of patients infected with HCV may have non identifiable routes of viral acquisition [3,7,8]. Therefore, identification and elimination of other possible transmission routes will play a significant role in HCV infection restriction [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Al-Kubaisy¹,

Al-Naggar²,

Ibrahim³

et al. 2014

Oral Biol Dent

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Background: The medical risk factor associated with hepatitis C virus (HCV) infection such as blood transfusion and surgery had been intensely studied in many countries. Up to 40% of patients infected with HCV may have non identifiable routes of viral acquisition. Dental extraction may be one of these risk factors. The purpose of the present study was to determine the existence of infection and the predominated HCV genotype among subjects with dental extraction. Material and methods: A case-control study involving pregnant women with and without history of dental extraction (n=776, n=2715, respectively). HCV antibodies (anti-HCV) were tested using subsequently third generation enzyme immunoassay (EIA-3) and immunoblot assay (Lia Tek-111). In addition 94 serum samples were subjected to molecular analysis using RT-PCR and DNA enzyme immunoassay (DEIA) method for HCV-RNA and genotypes. Results: Anti-HCV seroprevelance was significantly higher (6.3%) among cases with dental extraction (cases) than their counter control group (control) (2.63%) (p=0.00001). Dental extraction act as a risk factor for HCV infection (OR=2.73; 95% CI=1.8-3.9). HCV-RNA was found to be significantly higher (74.6%) in cases than (38.7%) control group (p=0.0016). No significant association between HCV genotypic and the history of tooth extraction but HCV-1b showed higher rate (90%) among dental extraction cases. Conclusion: Our study showed that dental extraction acts as a risk factor for acquiring HCV. Complete sterilization and cleaning of equipment is necessary.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Al-Kubaisy¹,

Al-Naggar²,

Ibrahim³

et al. 2014

Oral Biol Dent

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“…Several studies address the impact of HCV infection in the oral health. These studies highlight the dental diseases associated with both HCV-infection and its extrahepatic manifestations (EHMs) 39 Coates et al, studied the oral health state of HCVinfected persons based on the DMFT index (Decayed, Missing, Filled Teeth index). They found that, patients with chronic HCV infection had more significant dental pathological changes in teeth with carious lesions, expressed a larger number of missing teeth and less dental fillings as compared with the control 40 Moreover, using the CPITN index (Community Periodontal Index of Treatment Needs), HCV patients had more gingival bleeding and deeper periodontal pockets.…”

Section: Oral Diseases Related To Hepatitis C Virus Infectionmentioning

confidence: 99%

Periodontal disease as predictor of chronic liver diseases

Elbatae

Abdel‐Razik

Mousa

et al. 2020

Medical Journal of Viral Hepatitis

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“…Some extrahepatic manifestations of HCV infection such as Sjögren syndrome and oral lichen planus can also impact the status of the oral cavity [62,63]. In Sjögren syndrome, the secretion ability of the lachrymal and salivary glands is impaired.…”

Section: Chronic Hepatitis C Infection From An Oral Health Perspectivementioning

confidence: 99%

Periodontal Implications of Hepatitis C Infection

Șurlin¹,

Gheorghe²,

Foia³

et al. 2018

Hepatitis C - From Infection to Cure

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Periodontal tissues exhibit important vascular, lymphatic, and nervous connections with the rest of the body. Thus, periodontal inflammation caused by the interaction between the subgingival bacterial biofilm and the host immune response has an impact reaching further than the oral cavity. The concept of "periodontal medicine" reunites the bidirectional relationships that exist between periodontal disease and systemic conditions such as diabetes mellitus or cardiovascular disease. The chronic inflammation of hepatic tissues during hepatitis C virus (HCV) infection causes changes in the general homeostasis that can reverberate at periodontal level and influence periodontal inflammation. Various mechanisms such as insulin resistance or pro-inflammatory cytokines production could be the link between the two conditions. In addition, periodontal inflammation could impact HCV transmission, as HCV RNA molecules and antibodies have been found in infected patients' saliva and gingival fluid. During periodontal inflammation, gingival bleeding is frequent, and the viral molecules could enter oral fluids while being carried by peripheral blood cells. Clinical particularities that suggest the onset of periodontal disease have also been frequently observed in HCV-infected patients. The connections between periodontal disease and hepatitis C need to take into consideration by practitioners of both specialties due to their important implications on clinical manifestations and treatment strategies.

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Oral conditions associated with Hepatitis C virus infection

Cited by 24 publications

References 59 publications

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Is dental extraction a risk factor for contracting HCV infection: Abs, RNA and genotype detection

Periodontal disease as predictor of chronic liver diseases

Periodontal Implications of Hepatitis C Infection

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