The increased risk of sarcopenia in patients with cardiovascular risk factors in Suburb-Dwelling older Chinese using the AWGS definition

Abstract

The aim of the present study is to investigate the relationship between sarcopenia and cardiovascular risk factors (CVRF) in the Chinese elderly. A total of 1611 elderly individuals aged ≥60 years were enrolled in this study. The well-established CVRF of diabetes, hypertensions, and dyslipidemia were assessed. Sarcopenia was defined according to the recommended algorithm of the Asian Working Group for Sarcopenia (AWGS). Multiple logistic regression analyses and the linear regressions were used to evaluate the components of CVRF and the number of CVRF of elderly patients with sarcopenia. After adjusting for potential confounders, CVRF was associated with a high prevalence of sarcopenia in elderly Chinese populations. Furthermore, diabetes and hypertension, but not dyslipidemia, were found to be significantly associated with sarcopenia. The OR and 95% CI for sarcopenia of the participants with 1, 2, and 3 features of CVRF were 2.27(1.14–4.48), 4.13(1.80–9.46), and 4.90(1.01–23.81), respectively. A linear increase in the prevalence of sarcopenia was found to be associated with the number of CVRF components in the elderly population (P values for the trends < 0.001). Knowledge of known CVRF, particularly diabetes and hypertension, may help predict the risk for sarcopenia in the elderly.

Malnutrition in acute heart failure with preserved ejection fraction: clinical correlates and prognostic implications

“…Likewise, our findings also suggest that albumin‐based circulating nutritional surrogates may serve to discriminate overweight or obese patients as ‘nutritional healthy’ or ‘nutritional unhealthy’ ( Figure A–C ), whether mediated partly by a coupled BMI‐to‐nutritional relationship or equilibrated muscle‐protein patients remained to be determined. Considering the mixture of a more prevalent ‘sarcopenic obesity’ phenotype and a characteristic lean HFpEF phenotype in Asians and the potential deleterious cardiovascular effects associated with higher BMI, it is likely that baseline physical nutrition may play a more crucial role in determining long‐term survival and HF recurrence in Asian patients with HFpEF after discharge . Despite this, we still observed the ‘Obesity Paradox’ in our HFpEF cohort after discharge.…”

Assessing cardiovascular risks from a mid-thigh CT image: a tree-based machine learning approach using radiodensitometric distributions

“…Defined as sarcopenia, recent literature has interrogated its mediating and moderating roles in a wide range of adverse health outcomes, including its role in the etiology of cardiovascular pathophysiology. Catabolic inflammatory cytokine production and characteristic adiposity from the progression of sarcopenia have been linked with the onset of diabetes 8 , hypertension 9 , and dyslipidemia 10 -all of which are well-established risk factors for coronary heart disease (CHD) 11 and all-type cardiovascular disease (CVD) [12][13][14][15] . Chronic heart failure (CHF) patients frequently develop cardiac cachexia, a similar muscle wasting condition whose advanced stage has been implicated as an accelerated analogue of sarcopenic muscle degeneration 16 .…”

Sarcopenia is associated with hypertension in older adults: a systematic review and meta-analysis

“…Four articles [8,16,24,29] were divided into two or four studies as the participants were categorized into several groups according their characteristics. Eight studies [7][8][9]19,[28][29][30] addressed the association between sarcopenia and hypertension, and 11 studies [18,[25][26][27]31] focused on the association between handgrip strength and hypertension. The sarcopenia was defined by three methods, the European Working Group on Sarcopenia in Older People (EWGSOP) criteria [32], the Asian Working Group for Sarcopenia (AWGS) criteria, and ASM/weight (kg) less than one standard deviation (SD).…”

“…Six studies were conducted in China [18,19,28,31], two each in Republic of Korea [8] and Japan [26], and United States [9,25,34,35], one each in Turkey [30], Switzerland [27], Italy [7], and Spain [29].…”