The Increase of The Mean Platelet Volume in Patients With Intracerebral Haemorrhage

Arıkanoğlu, Adalet; Çevik, Mehmet Uğur; Uzar, Ertuğrul; Açar, Abdullah; Akıl, Eşref; Ekıcı, Faysal; Taşdemir, Nebahat

doi:10.4274/tnd.05325

Cited by 5 publications

(5 citation statements)

References 21 publications

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“…According to the results of our study, it cannot be used as the predictor of mortality, but we think it may be a parameter to be considered in patients with suspected intracerebral hemorrhage. Although platelet levels were found to be low in patients with intracerebral hemorrhage in the study of Arikanoglu et al, which is similar to our study, it was not significant in terms of mortality [16]. In a study conducted in the literature, they emphasized that especially the growth in intracerebral hematoma volume was associated with decreased platelet activity and caused a worse prognosis [35].…”

Section: Discussionsupporting

confidence: 87%

“…The Mean Platelet Volume (MPV), which is a marker of the functions of platelet cells, indicates platelet activation. In general, large platelets are considered to be more reactive [15,16]. It is reported in the literature that the MPV values increase in acute ischemic diseases and MPV values decrease in activation periods of chronic inflammatory diseases [17,18].…”

Section: Introductionmentioning

confidence: 99%

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Spontan intraparankimal kanamalarda Platelet Volüm İndex, MPV ve RDW değerlerinin mortalite ile ilişkisinin değerlendirilmesi

Atik

Cander

Yazıcı

et al. 2021

Family Practice and Palliative Care

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Introduction: Intracerebral Spontaneous Hemorrhage (ISH) is a sudden hemorrhage into the brain parenchyma as a result of a rupture of the cerebral vessels that are not related to traumas. The purpose of the present study was to evaluate the relation of mortality with Platelet Volume Index (PVI) scoring systems, which have been reported in a small number of studies in terms of blood RDW, MPV, platelet and intracranial hemorrhages in patients diagnosed with intraparenchymal hemorrhage in Emergency Departments. Methods: This study was performed retrospectively by examining patient files of patients who came to Emergency Medicine Clinic between 01.01.2019-31.12.2019. As a control group for comparison of blood parameters, blood parameters of 72 patients suitable for the same age population, without intraparenchymal haemorrhage. Results: A total of 54.10% (n=85) intraparenchymal bleeding patients (IPC) and 45.90% (n=72) healthy control groups (HCG) were included in the study. There was no statistically significant difference between the clinical results of IPC groups in terms of mortality of RDW parameter and MPV parameter (p=0.930; p=0.118). When PVI ratio was evaluated in IPC group and HCG; the mean PVI (MPV/Platelet ratio) in the IPC group was 4.37±1.66, and the PVI (MPV/Platelet ratio) in the HCG was 3.89±1.02.A statistically significant difference was found between the PVI in the patient group and the HCG.A statistically significant difference was found between the PVI ratio clinical results of the patients with IPC (p=0.043). Conclusion:Spontaneous Intraparenchymal hemorrhage are among the leading causes of stroke-induced mortality and disability. The Hemphill Score and hemorrhage volume are important factors in mortality evaluation in intraparenchymal hemorrhage. There are not many studied conducted on Platelet Volume Index, and it is an important marker in predicting mortality, especially in these patients.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Spontan intraparankimal kanamalarda Platelet Volüm İndex, MPV ve RDW değerlerinin mortalite ile ilişkisinin değerlendirilmesi

Atik

Cander

Yazıcı

et al. 2021

Family Practice and Palliative Care

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“…PD patients were examined by using Hoehn and Yahr scale (HYS) which is a scale for PD's severity that rates between 0 and 5 based on the level of clinical disabilities [ 24 ]. The control group consisted of 104 subjects, who were matched for age and sex without dementia, PD, any other neurodegenerative diseases, stroke, and hematologic disease [ 25 ]. Mean blood pressure levels were recorded after a 7-day followup and repeated measurements.…”

Section: Methodsmentioning

confidence: 99%

Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson’s Disease

Koçer

Yaman

Niftaliyev

et al. 2013

Current Gerontology and Geriatrics Research

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Platelets induce chronic inflammation which is a key step in atherosclerosis and may be involved in the progression of neurodegenerative diseases (NDD). We aimed to measure the mean platelet volume (MPV) and platelet count (PLC) in NDD patients. The present study was designed to investigate the platelet function by measuring MPV and PLC in NDD. A total of 182 outpatients with Alzheimer's (AD) or Parkinson's diseases (PD) were included. The control group consisted of 104 healthy subjects. Platelet count was similar between groups. MPV values of PD patients were higher than those of AD patients and controls (P < 0.001). MPV correlated negatively with Heohn and Yahr scale (HYS) score (P < 0.001). Increased MPV in patients with PD may point to a platelet dysfunction. High-grade inflammation presents with low levels of MPV as seen in PD patients with high HYS scores.

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“…Patients with AD were divided into 2 subgroups for mild (MMSE ≥ 18 points, 78 patients) and moderate (MMSE < 18 points, 31 patients) cognitive impairment. The control group consisted of 81 subjects, matched for age and sex, without dementia, stroke, or hematologic disease (21).…”

Section: Study Population and Proceduresmentioning

confidence: 99%

“…The control group consisted of 81 subjects, matched for age and sex, without dementia, stroke, or hematologic disease (21).…”

Section: Study Population and Proceduresmentioning

confidence: 99%

The increase of mean platelet volume in patients with Alzheimer disease

Koç¹,

Uzar²,

Çirak³

et al. 2014

Turk J Med Sci

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Background/aim: Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors. Materials and methods:A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini Mental State Examination (MMSE) was used for cognitive assessment. According to the test results, patients were divided into 2 subgroups, mild (MMSE ≥ 18) and moderate (MMSE < 18), and their MPV levels were compared.Results: MPV levels were higher in the AD group. There was no statistically significant difference between the moderate group and the mild group according to MPV values. Conclusion:Increased MPV in patients with AD may point to platelet dysfunction. MPV is an indicator of increased in vivo platelet activation. Hence, platelets could be the link between vascular risk factors and AD. The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.

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The Increase of The Mean Platelet Volume in Patients With Intracerebral Haemorrhage

Cited by 5 publications

References 21 publications

Spontan intraparankimal kanamalarda Platelet Volüm İndex, MPV ve RDW değerlerinin mortalite ile ilişkisinin değerlendirilmesi

Spontan intraparankimal kanamalarda Platelet Volüm İndex, MPV ve RDW değerlerinin mortalite ile ilişkisinin değerlendirilmesi

Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson’s Disease

The increase of mean platelet volume in patients with Alzheimer disease

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