The increase in the frequency of MICA gene A6 allele in oral squamous cell carcinoma

Liu, Chung-Ji; Lee, Yann-Jinn; Hsin-Fu, Liu; Dang, Ching-Wen; Che-Shoa, Chang; Yi-Shing, Leu; Chang, Kuo-Wei

doi:10.1034/j.1600-0714.2002.310602.x

Cited by 14 publications

(6 citation statements)

References 31 publications

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“…Our data showed Gamma delta T cell and Monocyte is potentially regulated immune cells. To our knowledge, Gamma delta T is a risk immune cell of OSCC progress (31). And also, Monocyte is a stable cell for detecting biomarkers in OSCC monitoring (32).…”

Section: Discussionmentioning

confidence: 92%

KIF14 acts as a prognostic biomarker correlates with LCP2/ ITGAMN/ immune cell infiltration in oral squamous cell carcinoma

Lei

Chen³

et al. 2023

Preprint

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Background: Kinesin family member 14 (KIF14) as an oncogene in many cancers. However, the clinical role and mechanism of KIF14 in oral squamous cell carcinomas (OSCC) is still largely unclear. Methods: Gene Expression Omnibus (GEO) databases was used to screen differentially expressed genes (DEGs) between OSCC and non-cancer tissues. KEGG pathway, Gene Ontology, and Reactome pathway analyses were performed on the DEGs. Hub genes were identified via protein-protein interaction (PPI) network analysis. ssGSEA was employed to recognize tumor-infiltrating immune cells. The biological function of KIF14in OSCC was tested by CCK-8, Flow cytometry as well as western blotting. Results: In this study, 7239 common DEGs were obtained from six datasets, with ten hub genes identified among the DEGs. Validation analyses revealed that KIF14 is a critical agent in the progress of OSCC. Knockdown KIF14 inhibits OSCC cells growth and induces apoptosis. And also, up-regulates cleaved-caspase-3 as well as Bax level and decreases Bcl-2 expression in OSCC cells. Gamma delta T cell and Monocyte were significantly correlated with overall survival for APOPA4 by ssGSEA assay. While, LCP2, and ITGAMN were up-regulated in OSCC with good prognostic efficacy and survival rate as well as positive correlate with APOA4 in OSCC. Meanwhile, knockdown KIF14 can suppress the expression of LCP2, and ITGAMN in OSCC cells. The ROC curve analysis was confirming the good survival status for LCP2, and ITGAMN with APOA4 in OSCC. Conclusions: Therapeutic strategies or biomarker using KIF14 could contribute to better clinical management/research for patients with OSCC.

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Section: Discussionmentioning

confidence: 92%

KIF14 acts as a prognostic biomarker correlates with LCP2/ ITGAMN/ immune cell infiltration in oral squamous cell carcinoma

Lei

Chen³

et al. 2023

Preprint

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“…Different predisposing associations were observed in Asians. In Taiwanese, MICA ‐ A6 alleles were found to be positively associated with OSCC, 15 while in Japanese MIC ‐ A5 . 1 allele was identified as a predisposing allele being characterized with a nucleotide insertion resulting in a stop codon and therefore truncated and ectopic molecule 28 .…”

Section: Discussionmentioning

confidence: 93%

“…Reports on MICA gene polymorphism and cancer associations, however, have focused mainly on two MICA polymorphisms: (i) the variable number of short tandem repeats in exon 5, encoding the transmembrane region of the molecule, that was shown to affect MICA subcellular localization and the sMICA levels, 25,26 and (ii) substitution of valine (Val) by methionine (Met) at position 29, encoded in exon 3 of the gene and affecting binding affinity to NKG2D receptor 27 . Available studies on MICA gene polymorphisms and OSCC are limited to only three populations 15,16,18 and to our knowledge no association analyses are available for MICB polymorphic variants. In the present study, we applied for the first time NGS approach based on whole‐gene amplification to analyze MICA and MICB allele associations in OSCC.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies addressed the relevance of MICA and MICB in OSCC focusing on genetic polymorphisms, 15–18 levels of sMICA and sMICB molecules, 14,19 and the levels of expression 11 . Although these studies suggested possible role of these NKG2D ligands in OSCC, the results showed contradicting results and were relatively limited and focused mainly on exon 5 polymorphisms of MICA genes.…”

Section: Introductionmentioning

confidence: 99%

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Associations of high‐resolution‐typing‐defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients

Ivanova¹,

Hadra²,

Yordanov

et al. 2021

J Oral Pathology Medicine

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Background Oral Squamous Cell Carcinoma (OSCC) is a malignancy characterized by an aggressive tumor growth and significant mortality. Clarifying mechanisms responsible for immunomodulation are among the main challenges for the development of personalized approaches for the management of patients with Oral Squamous Cell Carcinoma. The aim of the present study was to analyze the relevance of MICA and MICB to Oral Squamous Cell Carcinoma pathogenesis focusing on allele polymorphisms and the levels of soluble MICA and MICB molecules. Materials and methods 73 patients diagnosed with Oral Squamous Cell Carcinoma and 149 healthy controls from the Bulgarian population were included in the study. MICA and MICB polymorphism was analyzed at high‐resolution level using Next‐Generation Sequencing. Serum levels of soluble MICA and MICB molecules were measured by ELISA. Results Our results show significant protective association with MICB*002:01, while relatively rare alleles MICB*018, *019, and *020 were observed with statistically significant increased frequency in Oral Squamous Cell Carcinoma patients compared to controls. Additionally, a predisposing association was observed for MICA*008:01‐MICB*019 haplotype. A correlation analysis between functionally relevant MICA polymorphisms and sMICA showed that homozygosity for MICA‐A5.1 or 129Val in OSCC patients was associated with significantly higher serum levels of sMICA. Conclusion This is the first study showing significant associations between MICB alleles and Oral Squamous Cell Carcinoma and suggesting the possible role of MICB in immunosurveillance in Oral Squamous Cell Carcinoma development. Observed correlations between the levels of soluble MICA molecules and functionally relevant polymorphisms might represent a further step toward a better understanding of molecular mechanisms of Oral Squamous Cell Carcinoma and developing strategies for therapeutic targeting harnessing effective immunosurveillance.

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“…Recent papers have demonstrated that the MICA A5.1 polymorphism modulates cancer susceptibility in several cancer types including cervical cancer[20], oral squamous cell carcinoma[21–23] and hepatocellular carcinoma[24–26]. However, no epidemiologic studies to date have evaluated the MICA A5.1 polymorphism in relation to pancreatic cancer risk.…”

Section: Introductionmentioning

confidence: 99%

Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study

et al. 2019

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Background Pancreatic tumor cells may avoid immune surveillance by releasing the transmembrane major histocompatibility complex class I chain-related A (MICA) protein in soluble form (s-MICA). We hypothesized that the presence of the A5.1 polymorphism in the MICA gene, which encodes a truncated MICA protein, is associated with higher s-MICA levels and increased pancreatic cancer risk. Methods MICA alleles and s-MICA levels were measured in 121 pancreatic cancer cases and 419 controls. General linear regression with a log transformation assessed geometric means of s-MICA levels across MICA alleles. Unconditional logistic regression was used to calculate the odds ratio (OR) and 95% confidence intervals (CI) for pancreatic cancer associated with MICA alleles. Results After multivariate adjustment, participants with at least one copy of the A5.1 allele versus no A5.1 allele had 1.35 (95% CI: 1.05–1.74) times greater s-MICA levels (1.65 times higher for cases and 1.28, for controls) and increased risk of pancreatic cancer (OR = 1.91, 95% CI: 1.05–3.48). Conclusions Our study suggests higher risk of pancreatic cancer among those with the MICA A5.1 polymorphism, which may be explained by an increase in s-MICA secretion and impaired immune response. Impact These findings provide further evidence at the genetic and molecular level of the important role of MICA in pancreatic cancer development, and may have important implications with regards to pancreatic cancer screening.

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The increase in the frequency of MICA gene A6 allele in oral squamous cell carcinoma

Abstract: The results suggest that allele A6 in MICA might confer the risk of OSCC.

Cited by 14 publications

References 31 publications

KIF14 acts as a prognostic biomarker correlates with LCP2/ ITGAMN/ immune cell infiltration in oral squamous cell carcinoma

KIF14 acts as a prognostic biomarker correlates with LCP2/ ITGAMN/ immune cell infiltration in oral squamous cell carcinoma

Associations of high‐resolution‐typing‐defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients

Association between MICA polymorphisms, s-MICA levels, and pancreatic cancer risk in a population-based case-control study

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