The Incorporation of Tritiated Uridine in the Uterus and Vagina of the Mouse During Early Pregnancy

Miller, BG; Owen, W. H.; Emmens, C. W.

doi:10.1677/joe.0.0410189

Cited by 20 publications

(12 citation statements)

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“…It is concluded from the results of Finn & Martin (1967), Humphrey (19676), Miller et al (1968) and the present experiments that oestrogen secretion occurs con¬ tinuously after ovulation or after day 2 until day 5 or later. Although a single injec¬ tion of oestradiol increases uterine sensitivity (Finn, 1966;Humphrey, 1966Humphrey, , 1968a and induces implantation in ovariectomized rats and mice (Psychoyos, 1961(Psychoyos, , 1963Humphrey, 1967 a-c), the occurrence of a transient oestrogen surge before normal implantation is considered unlikely.…”

Section: Effect Of Day Of Transfersupporting

confidence: 58%

“…Shelesnyak (1963) has proposed that in the rat, oestrogen is released as a transient surge a short time before implantation begins and this proposal is supported by the work cited above. However, several workers state that is it unnecessary to postulate a surge and that oestrogen release could well occur at a continuous low level from ovulation until implantation (Zeilmaker, 1963;De Feo, 1967;Finn & Martin, 1967;Miller, Owen & Emmens, 1968).…”

Section: Introductionmentioning

confidence: 99%

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Induction of Implantation of Blastocysts Transferred to Ovariectomized Mice

Kw¹

1969

Journal of Endocrinology

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Blastocysts transferred to progesterone-treated ovariectomized mice implanted only if oestradiol was given at or after transfer. A dose of 1\m=.\0 m.g. Provera/day maintained the implants to term. Omission of priming with oestradiol did not prevent implantation. Transfers performed on day 0, 1 or 2 of progesterone treatment were completely unsuccessful, while transfers on day 8 were less effective than those performed on day 3 or 4. Administration of oestradiol 24 or 48 hr. beforehand did not prevent the induction of implantation by a second dose of oestradiol, and did not render the uterus 'refractory'. Treatment with 8 ng. oestradiol on days 1 to 5 or day 4 or 5 induced implantation of blastocysts transferred on day 4.It is concluded that oestrogen is not released as a surge before implantation, but is released continuously after ovulation.

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Section: Effect Of Day Of Transfersupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Induction of Implantation of Blastocysts Transferred to Ovariectomized Mice

Kw¹

1969

Journal of Endocrinology

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“…At this stage, the pattern of oestrogen secretion before implantation in the pregnant mouse is unknown, but from the results of Finn and Martin (1967), Miller, Owen, andEmmens (1968) andHumphrey (1968a) it would seem not to be of the nature of a surge, as believed by Shelesnyak (1962).…”

Section: Discussionmentioning

confidence: 95%

Interactions Between Oestradiol 3,17ß and Progesterone on the Induction and Growth of Deciduomata in Ovariectomized Mice

Kw¹

1969

Aust. Jnl. Of Bio. Sci.

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SummaryThe hormonal control of uterine sensitivity in progesterone-treated, ovariectomized mice was investigated by stimulating the deciduoma reaction by various means. Uterine sensitivity reached a peak on day 5 of progesterone treatment and then declined. Oestradiol before and after stimulation significantly increased the weight of the deciduomata induced by crushing, bradykinin, and compound 48/80 and increased uterine sensitivity so that intraluminal peanut oil could induce deciduomata. A single injection of 0·024 fJ-g of oestradiol 8 hr before intraluminal peanut oil also greatly increased uterine receptivity to oil. The dose of oestradiol and the time of injection of oestradiol and progesterone were critical parameters. Surprisingly, the hormonal requirements for uterine sensitivity to intraluminal peanut oil are more stringent than for transferred blastocysts.Uterine sensitivity on day 10 could be increased by multiple injections of oestradiol before stimulation, but responses were not as large as those obtained following oil on day 5.From these data it is concluded that uterine sensitivity depends on the length of progestation, being maximal on day 5 of progesterone treatment, and on the amount of oestrogen before stimulation -uterine sensitivity may be increased by either a single or multiple doses of oestradiol.

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“…A similar response has been found in the domestic guinea-pig (Orsini & Donovan, 1971) and chinchilla (C. M. Roberts, un¬ published observation). Implantation may be initiated by a gradual rise in oestrogen secretion such as has been postulated for mice (Miller, Owen & Emmens, 1968), although oestrogen-dependent implantation has not been indicated for the guinea-pig (Deanesly, 1960). The occurrence of antral follicles at about the same time as implantation suggests a connection.…”

Section: Discussionmentioning

confidence: 99%

Implantation in the Plains Viscacha, Lagostomus Maximus

Roberts¹,

Weir²

1973

Reproduction

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Accurately dated pregnancies were obtained in order to determine the time and mode of implantation in the plains viscacha, Lagostomus maximus. Implantation was completely interstitial and occurred antimesometrially on Day 18 post coitum. From each animal, very large numbers of single-celled and fragmenting eggs and relatively few blastocysts were flushed from the uterus up to the time of implantation. They were found at the ovarian end of the uterine horns, indicating that the blastocysts do not become spaced until just before implantation. Up to five blastocysts implanted progressively in each horn from the cervical to the ovarian end.No morphological or histological differences could be detected along the length of the uterus. The significance of these findings is discussed in relation to the fact that only those fetuses nearest the cervix in each uterine horn survive whilst the others are resorbed early in pregnancy.

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The Incorporation of Tritiated Uridine in the Uterus and Vagina of the Mouse During Early Pregnancy

Cited by 20 publications

References 0 publications

Induction of Implantation of Blastocysts Transferred to Ovariectomized Mice

Induction of Implantation of Blastocysts Transferred to Ovariectomized Mice

Interactions Between Oestradiol 3,17ß and Progesterone on the Induction and Growth of Deciduomata in Ovariectomized Mice

Implantation in the Plains Viscacha, Lagostomus Maximus

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