The incorporation of Pterodon pubescens fruit oil into optimized nanostructured lipid carriers improves its effectiveness in colorectal cancer

Design of Nanostructured Lipid Carriers Containing Cymbopogon martinii (Palmarosa) Essential Oil against Aspergillus nomius

“…In addition to a homogeneous size distribution, it may suggest that the compatibility between the components of the formulation was not affected and there is a lower tendency to coalescence [ 39 , 40 , 41 ]. A smaller particle size for the optimized formulation was also reported by Outuki et al [ 27 ], who attributed the smaller size to the use of a lower concentration of P80H, corroborating the results obtained in this work. The ζ-potential was close to −30 mV, suggesting good physical stability [ 44 ].…”

“…Considering the food industry, lipid nanoparticles have some advantages over other systems, such as biocompatibility, low toxicity, ease for large-scale production, and no need to use organic solvents to prepare the formulation [ 22 , 25 ]. Previous studies reported the successful loading of EOs into NLCs and showed they were efficient for protection, production of fortified food products, and as a potential natural food preservative [ 21 , 22 , 24 , 25 , 26 , 27 , 28 ]. Furthermore, since these nanoparticles are composed of lipids, they have the ability to interact with several bacterial and fungal cell types and can also facilitate the antimicrobial activity of EOs by improving the diffusion properties through biological membranes due to the nanosized and lipophilic nature [ 28 ].…”

Bioactive compounds of honey from different regions of Brazil: the effect of simulated gastrointestinal digestion on antioxidant and antimicrobial properties

“…To the best of our knowledge, there has been no study related to the carotenoid content of Pterodon pubescens ; nonetheless, other terpenoids have been found in this species, called furanoditerpenes, which have a vouacapan skeleton and are involved in the anti-inflammatory and antiproliferative activities of the flower in colorectal cancer. 51,52…”

“…To the best of our knowledge, there has been no study related to the carotenoid content of Pterodon pubescens; nonetheless, other terpenoids have been found in this species, called furanoditerpenes, which have a vouacapan skeleton and are involved in the anti-inflammatory and antiproliferative activities of the flower in colorectal cancer. 51,52 Among the citrus honey samples, there was a significant difference ( p < 0.05) in carotenoid concentrations. For instance, the H20 sample produced in southern Brazil presented a mean of 3.04 μg β-carotene per g, while samples H5 and H7 from southeastern Brazil did not differ statistically from each other and presented lower TCC values (1.14 and 1.11 μg β-carotene per g, respectively).…”

Recent progress in micro and nano-encapsulation of bioactive derivatives of the Brazilian genus Pterodon

“…Outuki et al [ 148 ] optimized the development of NLCs containing P. pubescens fruit oil that provided promising activities against human colon adenocarcinoma cell line (HT-29) in vitro. In this study, the NLCs formulation containing 5% Precirol® ATO 5, 0.5% P80H, 2.5% PEG-40H castor oil as an aqueous surfactant, and 2% P. pubescens oil presented the best physicochemical characteristics.…”