The incorporation of calix[6]arene and cyclodextrin derivatives into sol–gels for the preparation of stationary phases for gas chromatography

Delahousse, Guillaume; Peulon-Agasse, Valérie; Debray, Jean-Christophe; Vaccaro, Marie; Cravotto, Giancarlo; Jabin, Ivan; Cardinaël, Pascal

doi:10.1016/j.chroma.2013.10.007

Cited by 33 publications

(17 citation statements)

References 33 publications

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“…A new α -CD derivative was modified using a polyethylene glycolbased sol-gel method. The derivative used as the new stationary phase displayed remarkable column efficiency and satisfactory ability to separate aromatic isomers [65]. CD derivatives ( β -or γ -chirasil-dex) were used as chiral stationary phases (CSPs) to separate enantiomers.…”

Section: Six-position Displacementmentioning

confidence: 99%

Selective modifications at the different positions of cyclodextrins: a review ofstrategies

Liu¹,

Zhang²,

Tian³

2020

Turk J Chem

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Cyclodextrins (CDs) are natural, nontoxic, and biodegradable macrocyclic oligosaccharides. As supramolecular hosts, CDs have numerous applications in many aspects. However, nonsubstituted CDs have the disadvantages of solubility, unspecific recognition sites, and weak interactions with guest molecules. Therefore, new CD-based derivatives are successfully designed, synthesized, and widely used in various fields. This contribution outlines the research progress in CD derivatives. In particular, this review emphasizes the synthesis and application of CDs modified through functionalization in definite positions, random substitution, and reconstruction of the skeleton. At the end of this review, a summary and future directions are presented.Recently CDs have a wide range of applications in cancer treatment owing to the particularity of their different ring spaces. CDs could increase the solubility of anticancer flavonoids, such as curcumin and quercetin, which are very poorly soluble in water [41,42]. A novel CD complex of curcumin had superior attributes compared with free curcumin for cellular uptake and for antiproliferative and antiinflammatory activities, preferentially aggregating in the pancreas and possessing strong anticancer activity against pancreatic or tubulin surface cancer cells [41,43]. Similarly, the solubility of quercetin could be improved linearly with the increasing molality of CDs at the same temperature [44]. Selective modifications of CDs at definite positions Monosubstitution of CDsWhen natural CDs are unsuitable for a particular application, chemists begin to modify CDs to allow their derivatives to perform their intended function. To pursue an increasingly perfect structure, the idea of monosubstituted CD derivatives was conceived. However, the direct synthesis of single-isomer CD derivatives is challenging [45]. A single substitution has three possible isomers (Figure 2).

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Section: Six-position Displacementmentioning

confidence: 99%

Selective modifications at the different positions of cyclodextrins: a review ofstrategies

Liu¹,

Zhang²,

Tian³

2020

Turk J Chem

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“…However, these phases are not the best stationary phases for the separation of some isomers. Aromatic positional isomers [2], enantiomers [3] or congeners of persistent organic pollutants (POPs) [4,5] are difficult to separate and require stationary phases with shape selectivity. For instance, the analyses of micropollutants, such as polycyclic aromatic hydrocarbons (PAHs), organochloride pesticides or polychlorinated biphenyls (PCBs) in complex matrices, remain a challenge due to their high number of congeners/isomers and, in some cases, because of their high boiling points.…”

Section: Introductionmentioning

confidence: 99%

Physical Ionic Liquid/Polysiloxane Mixtures for Tuning the Polarity and the Selectivity of the Polysiloxane Stationary Phase for GC Analysis

et al. 2014

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“…In recent decades, calixarenes have received increasing attention for their exploitation as GC stationary phases due to their unique structures and physicochemical properties. [25][26][27][28] Mangia and coworkers rstly reported separation of alcohols, chlorinated hydrocarbons, and aromatic compounds by gas-solid chromatography with p-tert-butylcalix [8]arene absorbed on Chromosorb W. 29 However, it's difficult to coat unsubstituted calixarenes on the inner wall of the capillary column due to its high melting point and poor lm-forming ability, which restricts its application as stationary phase for GC. Subsequently, the derivatized calixarenes and physically blended calixarene/polysiloxane have been utilized as stationary phases in GC separations.…”

Section: Introductionmentioning

confidence: 99%

Performance and selectivity of lower-rim substituted calix[4]arene as a stationary phase for capillary gas chromatography

Sun

Shuai

et al. 2019

RSC Adv.

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The incorporation of calix[6]arene and cyclodextrin derivatives into sol–gels for the preparation of stationary phases for gas chromatography

Cited by 33 publications

References 33 publications

Selective modifications at the different positions of cyclodextrins: a review ofstrategies

Selective modifications at the different positions of cyclodextrins: a review ofstrategies

Physical Ionic Liquid/Polysiloxane Mixtures for Tuning the Polarity and the Selectivity of the Polysiloxane Stationary Phase for GC Analysis

Performance and selectivity of lower-rim substituted calix[4]arene as a stationary phase for capillary gas chromatography

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