The incorporation of [3H]uridine into nuclear RNA in the uterus of the RAT during early pregnancy

Heald, P. J.; O'grady, J. E.; Moffat, G.E.

doi:10.1016/0005-2787(72)90448-0

Cited by 8 publications

(1 citation statement)

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“…By 10.00 hours on Day 5 of pregnancy there is an increased synthesis of 130 P. J. Heald et al uterine RNA (Heald & O'Grady, 1970), accompanied by an increased rate of processing of nuclear RNA (Heald et al, 1972a) and an increased synthesis of ribosomal RNA (Heald et al, 1972b) which almost ceases by 10.00 hours on Day 6 if implantation and decidualization do not occur. Further, the uterus on Day 5 by 09.00 hours contains a new species of RNA not detectable in decidualizing tissue on Day 7 or in the uterus on Day 2 (Heald & O'Hare, 1973).…”

Section: Introductionmentioning

confidence: 94%

Nucleic Acid Metabolism of Cells of the Luminal Epithelium and Stroma of the Rat Uterus During Early Pregnancy

Heald¹,

O'grady²,

O’Hare³

et al. 1975

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The uptake of [5-3H]uridine into RNA and DNA of the cells of the uterine luminal epithelium, stroma and myometrium of the rat has been studied in early pregnancy using a technique for separation of the cell fractions before quantitative analysis. Comparisons of the metabolism between the pregnant and pseudopregnant horn of the unilaterally ovariectomized rat has shown that RNA and DNA synthesis are markedly increased by 04.00 hours on the morning of Day 5 in the pregnant horn. This increased metabolism occurs in all cell fractions and before the zona pellucida is shed. The results are discussed in relation to the onset of the decidual response.

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