Purpose This study aimed to identify the nature and extent of receptive and expressive prosodic deficits in children with high-functioning autism (HFA). Method Thirty-one children with HFA, 72 typically developing controls matched on verbal mental age, and 33 adults with normal speech completed the prosody assessment procedure, Profiling Elements of Prosodic Systems in Children. Results Children with HFA performed significantly less well than controls on 11 of 12 prosody tasks ( p < .005). Receptive prosodic skills showed a strong correlation ( p < .01) with verbal mental age in both groups, and to a lesser extent with expressive prosodic skills. Receptive prosodic scores also correlated with expressive prosody scores, particularly in grammatical prosodic functions. Prosodic development in the HFA group appeared to be delayed in many aspects of prosody and deviant in some. Adults showed near-ceiling scores in all tasks. Conclusions The study demonstrates that receptive and expressive prosodic skills are closely associated in HFA. Receptive prosodic skills would be an appropriate focus for clinical intervention, and further investigation of prosody and the relationship between prosody and social skills is warranted.

Specific language impairment (SLI) is a common developmental disorder characterized by difficulties in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors. We performed a high-density screen of SLI1, a region of chromosome 16q that shows highly significant and consistent linkage to nonword repetition, a measure of phonological short-term memory that is commonly impaired in SLI. Using two independent language-impaired samples, one family-based (211 families) and another selected from a population cohort on the basis of extreme language measures (490 cases), we detected association to two genes in the SLI1 region: that encoding c-maf-inducing protein (CMIP, minP = 5.5 × 10−7 at rs6564903) and that encoding calcium-transporting ATPase, type2C, member2 (ATP2C2, minP = 2.0 × 10−5 at rs11860694). Regression modeling indicated that each of these loci exerts an independent effect upon nonword repetition ability. Despite the consistent findings in language-impaired samples, investigation in a large unselected cohort (n = 3612) did not detect association. We therefore propose that variants in CMIP and ATP2C2 act to modulate phonological short-term memory primarily in the context of language impairment. As such, this investigation supports the hypothesis that some causes of language impairment are distinct from factors that influence normal language variation. This work therefore implicates CMIP and ATP2C2 in the etiology of SLI and provides molecular evidence for the importance of phonological short-term memory in language acquisition.

Marion (2005) Prosody and its relationship to language in school-aged children with high-functioning autism. Accessed from:http://eresearch.qmu.ac.uk/141/ Repository Use PolicyThe full-text may be used and/or reproduced, and given to third parties for personal research or study, educational or not-for-profit purposes providing that:• The full-text is not changed in any way • A full bibliographic reference is made • A hyperlink is given to the original metadata page in eResearch eResearch policies on access and re-use can be viewed on our This series consists of unpublished "working" papers. They are not final versions and may be superseded by publication in journal or book form, which should be cited in preference.All rights remain with the author(s) at this stage, and circulation of a work in progress in this series does not prejudice its later publication.Comments to authors are welcome. AbstractDisordered expressive prosody is a widely reported characteristic of the speech of individuals with autism. Despite this, it has received little attention in the research literature and the few studies that have addressed it have not described its relationship to other aspects of communication. This study investigated the prosody and language skills of 31 children with high functioning autism. The children completed a battery of speech, language and nonverbal assessments and a procedure for assessing receptive and expressive prosody.Language skills varied, but the majority of children had deficits in at least one aspect of language with expressive language most severely impaired. All of the children had difficulty with at least one aspect of prosody and prosodic ability correlated highly with expressive and receptive language.