The Inclusion of a Gemcitabine + Nab-paclitaxel Regimen as a 2nd Line Treatment for Advanced Pancreatic Cancer – First Experience

Vočka, Michal; Petruželka, Luboš

doi:10.14735/amko2017452

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Given the significant toxicity of FOLFIRINOX, a modified regimen has been suggested, where the 5-FU bolus is left out [15]. An alternative chemotherapy regimen often used in advanced pancreatic cancer and also in the setting of induction therapy before IRE is the combination of gemcitabine and Nab-paclitaxel [41]. Further studies assessing the best inductive treatment before IRE are needed before any general recommendation can be given.…”

Section: Induction Therapy In Locally Advanced Pancreatic Cancer Befomentioning

confidence: 99%

Irreversible Electroporation in Pancreatic Cancer

Eigl¹,

Erdem²,

Gloor³

et al. 2018

Advances in Pancreatic Cancer

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Pancreatic cancer is the deadliest of the gastrointestinal tract with 5-year survival rates of less than 5%. Given common asymptomatic early disease course, most patients (50%) present with an already metastatic disease, while only 20% can undergo potentially curative resection. The remaining 30% present with locally advanced disease, defined as extended vascular encasement, where the risk of surgical therapy often outweighs its benefits. Traditional thermal local ablative modalities (RFA, MWA, or cryotherapy) have the disadvantage that they are not applicable in proximity to vital vascular structures, which are abundant in the peripancreatic region. Irreversible electroporation (IRE) is an emerging non-thermal alternative that induces apoptosis of tumor cells by the delivery of short repetitive impulses of high-voltage electric current. Given its mostly non-thermal modality, IRE is not hampered by a heat-sink effect and is applicable with little risk around vascular structures, bile and pancreatic ducts. Recent research suggests that local tumor destruction through IRE improves overall survival, progression-free survival and quality of life in patients with locally advanced pancreatic cancer.

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Section: Induction Therapy In Locally Advanced Pancreatic Cancer Befomentioning

confidence: 99%