The Incidence of Unknown Diabetes mellitus and Impaired Glucose Tolerance in Idiopathic Presenile Cataract

Samarrai, Al; Sunba, M. S. Noor; Hassan, MuzdalifaElgailiYahaya

doi:10.1159/000417005

Cited by 2 publications

(1 citation statement)

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“…Metabolic disorder, such as diabetes mellitus (DM), is another risk factor of early-onset cataract. In patients with DM, glucosylation of lens crystallins contributes to the accumulation of glycation end products, causing aggregation of high-molecular-weight material and resulting in lens opacification [30]. Studies have demonstrated that hyperglycaemia is associated with the impairment of cochlear microcirculation, especially in the stria vascularis.…”

Section: Discussionmentioning

confidence: 99%

Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

et al. 2020

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Background: This study aimed to investigate the association between early-onset cataract and tinnitus using a population-based database. Methods: Retrospective claims data from the Taiwan National Health Insurance Research Database were analysed. Study subjects comprised patients with early-onset cataract, aged 20-55 years and diagnosed between 2000 and 2010 (n = 2084) and a comparison cohort without the disease (n = 8336). Both cohorts were followed until 2010 to estimate the incidence of tinnitus. To calculate the risk of tinnitus in the case and control groups, Cox proportional hazards models were used and presented as hazard ratios (HRs), adjusted HRs (aHRs) and 95% confidence intervals (CIs). Results: Patients with early-onset cataract had 1.53-fold increased risk (HR = 1.53, 95% CI = 1.17-2.01, p < 0.01) of developing tinnitus than controls. The number of patients with vertigo (p < 0.0001), insomnia (p < 0.0001), anxiety (p < 0.0001) and hearing loss (p < 0.0001) as comorbidities was also significantly higher in the case group. After adjusting for age, sex and all listed comorbidities, patients with increasing age (aHR = 1.04, 95% CI = 1.02-1.07), early-onset cataract (aHR = 1.32, 95% CI = 1.01-1.74), vertigo (aHR = 1.75, 95% CI = 1.15-2.67), insomnia (aHR = 1.48, 95% CI = 1.14-1.93) and hearing loss (aHR = 6.20, 95% CI = 3.58-10.70) had significantly higher risk of tinnitus. Conclusions: Patients with early-onset cataract are at an increased risk of developing tinnitus in subsequent years and should receive further evaluation for early diagnosis and management if any signs of tinnitus occur.

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Section: Discussionmentioning

confidence: 99%

Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

et al. 2020

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Diabetes, fasting blood glucose and age-related cataract: the Blue Mountains Eye Study

Rowe

Mitchell²,

Cumming³

et al. 2000

Ophthalmic Epidemiology

115

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These findings support previous research showing that diabetes has a harmful effect on the lens. The markedly increased risk for PSC may also have been reflected in the association found between diabetes and past cataract surgery. Contrary to findings from the Beaver Dam Eye Study, we found only a weak association with cortical cataract, which was not statistically significant after adjusting for other known cataract risk factors.

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The Incidence of Unknown Diabetes mellitus and Impaired Glucose Tolerance in Idiopathic Presenile Cataract

Cited by 2 publications

References 0 publications

Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

Diabetes, fasting blood glucose and age-related cataract: the Blue Mountains Eye Study

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