Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

Hsieh, Yi-Ching; Chang, Cheng-Hsien; Tsai, Yi–Yu; Lin, Cheng‐Li; Ng, Telk-Ying; Chiang, Chun-Yi

doi:10.1186/s12886-020-01497-8

Cited by 4 publications

(4 citation statements)

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“…In addition, the number of individuals with comorbidities (anxiety, hearing loss, vertigo, insomnia) was significantly higher among the patients with cataract than in controls [445]. Furthermore, other studies showed that hearing loss, insomnia and anxiety were highly relevant to tinnitus severity [445][446][447][448]. Interestingly, Neri et al [449] showed that the levels of oxidative damage markers (malondialdehyde, myeloperoxidase, 4-hydroxynonenal) were significantly higher in patients with tinnitus than in controls, whereas glutathione peroxidase (an antioxidant) had lower activity, thus probably sharing similar pathogenesis with development of cataract.…”

Section: Hearing Loss Tinnitus Vibrations Whiplash Trauma and T Gondi...mentioning

confidence: 88%

“…Tinnitus and cataracts also were reported to have a significant relationship with the parasite infection [443,444], and Hsieh et al [445] found that patients with cataract had higher hazard ratio developing tinnitus than controls (OR = 1.53, 95% CI: 1.17-2.01, p < 0.01). In addition, the number of individuals with comorbidities (anxiety, hearing loss, vertigo, insomnia) was significantly higher among the patients with cataract than in controls [445]. Furthermore, other studies showed that hearing loss, insomnia and anxiety were highly relevant to tinnitus severity [445][446][447][448].…”

Section: Hearing Loss Tinnitus Vibrations Whiplash Trauma and T Gondi...mentioning

confidence: 99%

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Solving the New Puzzle(s) 2014-2022: Flammer Syndrome Probably Represents a Mild Endophenotype of Raynaud’s Phenomenon Mainly Associated with Ocular Disturbances and Also Due to Latent T. gondii Infection

Prandota¹

2023

J Clin Med Cur Res

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negative effect on quality of life [9]. The study of 334 healthy subjects aged 50 years or elder in Japan showed that proportion of participants with increased sensitivity to cold widely ranged (6.1%-30.8% men, 14.3%-28.3% women) [12].In Eastern Asian populations CHHF occurs in 20%-52% of subjects [13][14][15], and ratio of men to women is 2:3 [16]. In Japan, this condition called "hiesho" is quite common involving over 60% of females, and in the latter stage of pregnancy "hiesho" manifests in about 40% of women, particularly in the advanced maternal age [17,18]. One study comparing Japanese with Brazilians reported that 57% of Brazilian pregnant women were aware of cold sensations [19,20]. CHHF is associated also with RP, gastric disturbances [21], as well as gynecological disorders, such as infertility and dysmenorrhea [22,23]. Nb. T. gondii infection causes ovarian dysfunction and disturbances in sperm motility, viability and concentration values, epididymis weight, and testicle inflammation [24][25][26][27][28].The presence of "hiesho" was found to be risk factor which can also lead to abnormal delivery because of weak labor pains, prolonged labor and atonic bleeding, premature delivery, amnion membrane rupture [17,29,30].In this context, it should be added that traditional Japanese fish dishes sushi and sashimi may, at least in part, play a role in development of these disorders [31], especially that wide distribution of T. gondii amongst sea fish and mammals may affect human health worldwide (e.g. the highest prevalence of the pathogen was found in otter (54.8%), and dolphin, whale and porpoise (30.92%) [32]. B. FS heritability.In Europe, most of FS symptoms appear in puberty and alleviate along with age, in women after menopause begun [33], albeit in the study of 3067 persons aged 65 years or elder 23.6% men and 28.6% women had cold extremities [34]. Importantly, parents of FS subjects also had similar symptoms which may suggest a heritability of this clinical entity [3,4]. Moreover, Konieczka & Erb [4] noted that there is a relationship between FS and RP, and suggested a genetic background of RP [35][36][37][38], but they believed that additional factor(s) may also play a role [4,35]. Nb. genetic factors appeared to be important in the development of RP as has been demonstrated in one familial and twin study [39]. FS often occurs in individuals who are slender, have a low blood pressure, are active, but also have unusually cold extremities, increased pain sensitivity, altered circadian rhythm, and prolonged falling asleep time [40,41]. C. Pathophysiological changes in FS.Individuals with FS have the autonomic nervous system imbalance with sympathetic predominance [4,42], lymphocytes and leukocytes in the eye have altered gene expression, and activated astrocytes in the retina also change their gene expression and morphology [2,[43][44][45], slightly increased plasma endothelin-1 (ET-1) levels, and increased systemic oxidative stress [5,46]. They also have enhanced sensitivity to some drugs, such as for ...

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Section: Hearing Loss Tinnitus Vibrations Whiplash Trauma and T Gondi...mentioning

confidence: 88%

Section: Hearing Loss Tinnitus Vibrations Whiplash Trauma and T Gondi...mentioning

confidence: 99%

Solving the New Puzzle(s) 2014-2022: Flammer Syndrome Probably Represents a Mild Endophenotype of Raynaud’s Phenomenon Mainly Associated with Ocular Disturbances and Also Due to Latent T. gondii Infection

Prandota¹

2023

J Clin Med Cur Res

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“…Intriguingly, not only the somatosensory system may be involved in tinnitus. Visual snow, the visual analogue of tinnitus [ 29 ], is comorbid with tinnitus [ 30 ], and cataract is a risk factor for tinnitus [ 31 ]. This suggests that possibly not only the somatosensory system is involved in tinnitus generation but in some patients the visual system may influence it.…”

Section: Etiological Factorsmentioning

confidence: 99%

Tinnitus: Clinical Insights in Its Pathophysiology-A Perspective

Langguth,

de Ridder,

Schlee

et al. 2024

JARO

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Tinnitus, the perception of sound without a corresponding external sound source, and tinnitus disorder, which is tinnitus with associated suffering, present a multifaceted clinical challenge due to its heterogeneity and its incompletely understood pathophysiology and especially due to the limited therapeutic options. In this narrative review, we give an overview on various clinical aspects of tinnitus including its heterogeneity, contributing factors, comorbidities and therapeutic pathways with a specific emphasis on the implications for its pathophysiology and future research directions. Tinnitus exhibits high perceptual variability between affected individuals (heterogeneity) and within affected individuals (temporal variability). Hearing loss emerges as predominant risk factor and the perceived pitch corresponds to areas of hearing loss, supporting the compensatory response theory. Whereas most people who have tinnitus can live a normal life, in 10–20% tinnitus interferes severely with quality of life. These patients suffer frequently from comorbidities such as anxiety, depression or insomnia, acting as both risk factors and consequences. Accordingly, neuroimaging studies demonstrate shared brain networks between tinnitus and stress-related disorders shedding light on the intricate interplay of mental health and tinnitus. The challenge lies in deciphering causative relationships and shared pathophysiological mechanisms. Stress, external sounds, time of day, head movements, distraction, and sleep quality can impact tinnitus perception. Understanding these factors provides insights into the interplay with autonomic, sensory, motor, and cognitive processes. Counselling and cognitive-behavioural therapy demonstrate efficacy in reducing suffering, supporting the involvement of stress and anxiety-related networks. Hearing improvement, especially through cochlear implants, reduces tinnitus and thus indirectly validates the compensatory nature of tinnitus. Brain stimulation techniques can modulate the suffering of tinnitus, presumably by alteration of stress-related brain networks. Continued research is crucial for unravelling the complexities of tinnitus. Progress in management hinges on decoding diverse manifestations, identifying treatment-responsive subtypes, and advancing targeted therapeutic approaches.

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“…Presenile cataract is defined as the opacification of lens and/or its capsule before the age of 50 years when all other known causes of cataract have been ruled out [8][9][10] . This will definitely add on to the already existing burden of age-related cataract in India and worldwide.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors and Types of Presenile Cataract in Patients Attending a Tertiary Care Hospital in Kerala- A Retrospective Study

Dhanya

Abraham

2021

Int J Res Rev

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Background: Cataract is a major cause of blindness worldwide with a greater prevalence in developing countries like India. Presenile cataract refers to an onset of this disease below 50 years of age. Objectives: To study the factors associated with development of presenile cataract among the total cataract patients who attended out-patient clinic of Ophthalmology department from January 2016 to July 2017 and to find out the proportion of different types of presenile cataract. Method: The study includes patients who had undergone cataract surgery in the Department of Ophthalmology Government Medical College, Ernakulam from January 2016 and June 2017. Data was retrospectively entered and analysed. Results: There were 100 (49 males and 51 females) patients between the age 30 and 50 years. Around 70 study participants had co-morbidities. The average axial length was 22.5532mm, the average haemoglobin content was 13.01 g/dL, average total count was 8590.85, average BL urea was 22.755 mg/dL, average serum creatinine concentration was 0.9611 mg/dL and average GRBS concentration was 131.43 mg/dL. Drug history of 69 patients was observed in the current study. Conclusion: The most common type of cataract seen was posterior subcapsular cataract followed by mature cataract. Diabetes mellitus was the predominant risk factor in posterior subcapsular cataract. Keywords: Presenile cataract; Risk factors; Posterior subcapsular cataract.

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Increased risk of tinnitus in patients with early-onset cataracts: a nationwide population-based case-control study

Cited by 4 publications

References 38 publications

Solving the New Puzzle(s) 2014-2022: Flammer Syndrome Probably Represents a Mild Endophenotype of Raynaud’s Phenomenon Mainly Associated with Ocular Disturbances and Also Due to Latent T. gondii Infection

Solving the New Puzzle(s) 2014-2022: Flammer Syndrome Probably Represents a Mild Endophenotype of Raynaud’s Phenomenon Mainly Associated with Ocular Disturbances and Also Due to Latent T. gondii Infection

Tinnitus: Clinical Insights in Its Pathophysiology-A Perspective

Risk Factors and Types of Presenile Cataract in Patients Attending a Tertiary Care Hospital in Kerala- A Retrospective Study

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