The Incidence of Peyronie’s Disease in Rochester, Minnesota, 1950 through 1984

Abstract

Peyronie's disease was diagnosed in 101 male residents of Rochester, Minnesota between 1950 and 1984. Mean patient age at diagnosis was 53 years. The average age-adjusted annual incidence rate of 25.7 and a prevalence rate of 388.6 per 100,000 male population were noted. The steady increase in incidence with time may reflect an increasing tendency to obtain medical help. However, the possibility of a true increase in the incidence rate cannot be ruled out. An effort was made to identify possible risk factors and other disease associations. Rheumatoid arthritis and hypertension were more common among the patients compared to the Rochester population. In contrast, no excess of diabetes mellitus was observed among patients with Peyronie's disease.

The association between Peyronie's and Dupuytren's disease

“…4 The very first cross-sectional study giving the proposed incidence and prevalence rates of PD was published in 1991 by investigators from Minnesota, USA. 5 The reported prevalence rate of 0.38% was consistent with earlier reports. It was estimated that there were more than 423 000 men with PD in the USA at that time and that 32 000 new cases occurred annually.…”

“…25 A comparable percentage (9.9%) was also observed in the Minnesota study. 5 Hindocha et al report a mean age of onset in familial DD of 49 years and 55 in non-familial DD. 13 This may explain the very low percentage of coexisting DD in the study by Levine et al 21 Finally, the varying or unknown follow-up periods in the different studies may explain the wide ranges of coexisting DD in PD.…”

“…Previous reports concerning coexisting DD in patients presenting with PD show ranges varying from 0.01 to 58.8%, a positive family history for PD in 1-4% and a positive family history for DD in 9.8% (Table 2). 5,9,[14][15][16][17][18][19][20][21][22][23][24] The series from the UK, Italy, Australia and Serbia show the highest percentage of PD patients with coexisting DD. 9,15,17,19,24 The two reports focusing on PD patients o40 years show a lower percentage of coexisting DD.…”

“…13 The literature concerning coexisting DD in patients presenting with PD shows wide ranges varying from 0.01 to 58.8%. 5,9,[14][15][16][17][18][19][20][21][22][23][24] The aim of this study is to investigate the coexistence of DD in a consecutive series of patients with PD and their clinical characteristics, presenting at the outpatient urological clinic of the University Medical Centre Groningen, The Netherlands.…”

Peyronie's disease: a critical appraisal of current diagnosis and treatment

“…4 Selection bias likely accounts for the 16% prevalence reported from tertiary referral centers treating men with erectile dysfunction (ED). 5 Historical reports of prevalence as low as 0.4% 6 contribute to the belief that PD is an uncommon disorder. Other authors have estimated the prevalence to approximate 1%.…”