The incidence of pediatric malignant soft tissue tumors of the skin and subcutaneous tissue

Liszewski, Walter; Maguiness, Sheilagh; Greengard, Emily; Boull, Christina

doi:10.1111/pde.13669

Cited by 5 publications

(8 citation statements)

References 3 publications

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“…1 CCSST is a rare tumor with 3 case series reported in children and the estimated incidence is 0.11 per 1 million children. [1][2][3][4][5] The tumor usually occurs in young to middle-aged adults and is equally distributed between the sexes. 4,5 CCSST occurs most commonly on the extremities, predominantly in the foot and ankle area.…”

Section: Discussionmentioning

confidence: 99%

A blue‐colored subcutaneous nodule on a child's sole

Kim

Lee

2023

Pediatric Dermatology

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A 13-year-old girl presented with a 1-year history of a nodule on the plantar surface of her right foot. The lesion was gradually increasing in size causing intermittent pain during walking. The patient did not recall any injury to the site. The patient's previous medical and family history were unremarkable. On physical examination, there was a 2.0 cm, slightly bluish to skin-colored, fixed, and firm subcutaneous nodule on the plantar aspect of the right foot, proximal to the third toe (Figure 1). A punch biopsy was obtained (Figures 2 and 3).

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Section: Discussionmentioning

confidence: 99%

A blue‐colored subcutaneous nodule on a child's sole

Kim

Lee

2023

Pediatric Dermatology

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“…Rhabdomyosarcoma (RMS) represents half of MSTT, followed by infantile fibrosarcoma (IFS) (24.5%), and malignant rhabdoid tumors (14.2%), which all may present as a lump or bump 2 . RMS is the most common sarcoma of the head and neck in children.…”

Section: Malignant Soft Tissue Tumors (Mstt)mentioning

confidence: 99%

“…Undifferentiated pleomorphic sarcoma (previously referred to as malignant fibrous histiocytoma) is rare in children. According to data from a SEER analysis 2000–2014, it manifests in the skin in 73.4% of cases 2 . Patients typically present with a painless enlarging mass on the upper extremities.…”

Section: Malignant Soft Tissue Tumors (Mstt)mentioning

confidence: 99%

“…Patients typically present with a painless enlarging mass on the upper extremities. The most common age of presentation is 15–19 years 2 . Prognosis is determined based on the size and depth of the tumor and histological grade of the tumor cells.…”

Section: Malignant Soft Tissue Tumors (Mstt)mentioning

confidence: 99%

“…Knight and Reiner's retrospective review of over 700 superficial lumps in children that underwent biopsy found that less than 1.5% of lesions were malignant 1 . Malignant soft tissue tumors (MSTT), though rare, represent 7.4% of all pediatric cancers, compared to 1.5% of adult cancers, and several MSTTs present in the skin 2 …”

Section: Introductionmentioning

confidence: 99%

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Lumps and bumps: What not to miss

Levin

Kinariwalla

Behr

et al. 2022

Pediatric Dermatology

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The evaluation of pediatric patients with subcutaneous nodules remains a diagnostic challenge. Pediatric dermatologists are regularly confronted with patients who have a nonspecific nodule. Though most masses that require evaluation are ultimately benign, the possibility of a more aggressive process, including borderline or malignant neoplasms, underscores the pivotal role of the pediatric dermatologist in recognizing these lesions. The aim of this review is to provide an overview of lumps and bumps that are important to recognize to prevent delay in diagnosis or treatment of a serious underlying condition. Clinical clues that may lead the pediatric dermatologist to have a higher index of suspicion for more aggressive lesions are reviewed. Suggestions for evaluation and workup, as well as tips for the difficult to discern lesion, are proposed.

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Ultrasound performance in pediatric deep soft-tissue tumor characterization

Li,

Chen,

Jin

et al. 2023

Sci Rep

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This study investigated the performance of ultrasonography in diagnosing deep soft-tissue tumors and tumor-like lesions in children with histological results. Demographic information and ultrasound characteristics of benign and malignant masses were statistically analyzed. Three radiologists (Radiologists 1, 2, and 3) independently reviewed the ultrasonography studies while being blinded to the medical history and other imaging findings. The 82 lesions included in the study were histopathologically classified as malignant (n = 25) or benign (n = 57). No statistically significant differences were observed between the benign and malignant subgroups regarding age (p = 0.059), sex (p = 1.0), disease course (p = 0.812), presence or absence of symptoms (p = 0.534), maximum diameter (p = 0.359), margin (p = 1.0), calcification (p = 0.057), or blood Adler type (p = 0.563). However, statistically significant differences were observed between the benign and malignant subgroups in terms of isolated or Multiple occurrences (p < 0.001), history of malignancy (p < 0.001), shape (p < 0.001), and echogenicity (p < 0.001). Parameters such as tumor shape (p = 0.042, OR = 6.222), single or multiple occurrences (p = 0.008, OR = 17.000), and history of malignancy (p = 0.038, OR = 13.962) were identified as independent predictors of benign and malignant tumors. The diagnostic sensitivities evaluated by the three radiologists were 68.0%, 72.0%, 96.0%, respectively, while the specificities were 77.2%, 82.5%, 77.2%, respectively. Ultrasound demonstrates good performance in the diagnosis of benign deep lesions such as hemangiomas/venous malformation and adipocytic tumors. Multiple irregular morphologies and a history of malignancy were identified as independent risk factors for malignant masses. The experience of radiologists in recognizing specific tumors is important. Careful attention should be paid to masses with ambiguous ultrasound features, as well as small lesions.

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The incidence of pediatric malignant soft tissue tumors of the skin and subcutaneous tissue

Cited by 5 publications

References 3 publications

A blue‐colored subcutaneous nodule on a child's sole

A blue‐colored subcutaneous nodule on a child's sole

Lumps and bumps: What not to miss

Ultrasound performance in pediatric deep soft-tissue tumor characterization

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