The incidence of leukaemia in patients with polycythaemia vera treated by 32P

Ledlie, E.M.

doi:10.1016/s0009-9260(60)80037-2

Cited by 18 publications

(6 citation statements)

References 5 publications

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“…A review of the literature since 1897, revealed 48 reports of well documented Beard et al, 1975;Preisler and Lyman, 1977;Knospe and Gregory, 1971;Tchernia et a/., 1976;Sahakian et al, 1974;Carey et al, 1967;Woodliff and Dougan, 1964;Rheingold et al, 1963;Foucar et al, 1979;Tulliez et a!., 1974;Ezdinli el al., 1969;Aksoy et al, 1972;Moloney, 1959, Thorpe, 1964Meyer and Boxer, 1973;Ledlie, 1960;Seaman, 1969;Swanson and Cook, 1977) cases of HAL (all since 1959). The criteria used to define these previously published cases were: (1) normocellular or hypocellular marrows, (2) 3 30 per cent lymphoblasts or myeloblasts + atypical promyelocytes, (3) no secondary malignancy responsible for the decreased marrow cellularity (for example, multiple myeloma or marrow involvement in Hodgkin's disease) and (4) no associated chronic myelogenous leukemia.…”

Section: Methodsmentioning

confidence: 99%

Hypoplastic acute leukemia: Review of 70 cases with multivariate regression analysis

Berdeaux¹,

Glasser²,

Serokmann³

et al. 1986

Hematological Oncology

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Between 1971 and 1984, 22 of 190 adult patients (11.6 per cent) with acute leukemia seen at the University of Arizona had hypocellular acute leukemia (HAL), defined as lymphoblasts or myeloblasts (plus atypical promyelocytes) of greater than or equal to 30 per cent, but marrow cellularity of the core biopsy or clot section of less than or equal to 50 per cent based on a 1000 point count. These 22 patients with HAL plus the 48 previously published patients with well documented HAL (combined series of 70 patients) were evaluated in detail with multivariate analysis. The median leukocyte count was 2700/microL, hemoglobin of 8.2 g/dl, and platelet count 63,000/microL. Circulating blasts were noted in 27 of 52 patients (52 per cent). Twenty-seven of 34 patients (79 per cent) had abnormal cytogenetics. The overall median survival was 8 months (range: 0.1-48). The median survival for the 22 patients managed with supportive care alone was 4 months, 6 months for the 16 patients treated with non-aggressive induction therapy, and 13 months for the 32 patients treated with aggressive induction therapy (p less than 0.02 versus other categories). Multivariate analysis confirmed that aggressive induction therapy was a major favourable prognostic factor (p = 0.016). Multivariate analysis of the aggressively induced patients revealed that younger patients (less than or equal to 65; p = 0.04) and patients with no AHD (p = 0.09) lived longer. Thus, aggressive remission induction can be attempted in HAL and appears to contribute to prolonged survival especially under age 65 years.

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Section: Methodsmentioning

confidence: 99%

Hypoplastic acute leukemia: Review of 70 cases with multivariate regression analysis

Berdeaux¹,

Glasser²,

Serokmann³

et al. 1986

Hematological Oncology

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“…Thus MacDiarmid (1965) has found chromosomal damage after 32P administration. Ledlie (1960) has pointed out that the occurrence of acute leukaemia in her series was two and a half to four years after 32P administration and similar to the time interval after whole-body irradiation. Also, Modan and Lilienfeld (1965) have shown a correlation between the dose of 32P and the incidence of acute leukaemia.…”

Section: Discussionmentioning

confidence: 58%

“…For example, among the 69 deaths in this group reported in the review of Modan and Lilienfeld (1965) there was one case of acute leukaemia ; a single case was reviewed by Williams and Mendel (1954); Dameshek (1950) (1954) .. 39 Lawrence (1955) 73 Calabresi and Meyer (1959) 28 Ledlie (1960) 21 Halnan and Russell (1965) The occurrence of acute erythraemic myelosis, or erythroleukaemia, in polycythaemic patients is rare. A case of acute erythroleukaemia was reported by Dameshek and Gunz (1964), and cases of acute erythraemic myelosis by Dammert and Kaipainen (1960) in a 32P-treated patient, and by Perkins et al (1964) in a patient treated by venesection, intravenous nitrogen mustard, and thiotepa.…”

Section: Discussionmentioning

confidence: 98%

Treatment of polycythaemia vera.

Watkins¹,

Fairley²,

Scott³

1967

BMJ

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Age, per se, plays no direct part in determining rate of change of pressure in these populations even though, as is seen in Figs. 1 and 2, mean pressures are much higher in the old than in the young and even though almost all old people in these populations have high pressures. Age appears to play a part solely because the blood-pressure changes on average are positive and increase with higher pressures.'he relation between change of pressure and mean pressure also appears to be a graded phenomenon-the higher the pressure the greater the rate of increase-and seems partially to reconcile the conflicting views on the nature of unexplained hypertension.If this relation were found to be causal it could explain the observations that some individuals and some races show no apparent increase in pressure with age. For example, the populations in Oceania studied by Maddocks (1961) and Lovell (1963), where old people have the same pressures as young adults, have mean pressures below the levels at which our data suggest that a self-perpetuating mechanism could be implicated. But our analysis has shown only an association between change of pressure and mean pressure, not a causal relationship. It is possible that minor but sustained increases of pressure, due to a variety of environmental and genetic influences, could lead to changes in function and structure which perpetuate a vicious circle, but some other factor acting in a similar fashion may underlie the relationship found.A controlled therapeutic trial might show whether the pressure attained determines the subsequent increments in pressure; if, for example, it could be shown that after a reduction in pressure effected by hypotensive drugs the subsequent changes in pressure of previously hypertensive subjects revert to those occurring spontaneously in subjects with lower pressures, this would be strong evidence for a causal relationship. SummaryData obtained from the longitudinal surveys of arterial blood pressure in two general population samples have been used to examine the relation between change of blood pressure, the mean pressure attained, and age.It has been shown, by multiple regression analysis of change of pressure on mean pressure and age, that in these populations changes in pressure during intervals of 10 and 8O years are highly significantly related to mean pressures, but only indirectly related to age. This implies that ageing plays no direct part in determining the rate of change of pressure; age appears to play a part solely because the blood-pressure changes are positive and increase with higher pressures.If change of pressure is determined.by attained pressure, this would explain the observation that some individuals and some races show no apparent increase of pressure with age, and would partially reconcile the conflicting views on the nature of unexplained hypertension. However, the evidence has shown only association, not causality.We wish to record our thanks to the people of the Rhondda Fach and Vale of Glamorgan who so willingly continue to c...

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“…Factors of this kind might have been involved in producing largely contradictory results in retrospective studies reported by several centers [2,10,13,16,17,26]. therapy; however, they do not permit any appreciation of the individual patient's risk when radioactive phosphorus is administered.…”

Section: Radioactive Phosphorusmentioning

confidence: 99%

Present status of32P-therapy in management of polycythemia vera

Meuret

1975

Klin Wochenschr

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The aim of this study is to assess the present status of 32P-therapy in the management of polycythemia vera. The nature of the disease and its associated clinical problems was considered with respect to the characteristics of the different therapeutic approaches. We concluded that 32P is preferably administered to older patients, especially if long term remissions are achieved, if drugs are taken unreliably, or if patients are difficult to supervise. At present chemotherapy is preferably administered to younger patients, to those who respond inadequately to 32P, or who demonstrate early relapsing hyperproliferation of granulocytopoiesis, or who require 32P-administration at intervals shorter than one year.

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The incidence of leukaemia in patients with polycythaemia vera treated by 32P

Cited by 18 publications

References 5 publications

Hypoplastic acute leukemia: Review of 70 cases with multivariate regression analysis

Hypoplastic acute leukemia: Review of 70 cases with multivariate regression analysis

Treatment of polycythaemia vera.

Present status of32P-therapy in management of polycythemia vera

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