The Incidence of Helicobacter Pylori-infection Gastritis in Children with Recurrent Abdominal Pain

Abstract

Background: Gastritis is a disease characterized by inflammation process in the mucosa layer of the stomach. It happened as a response to damage, that causes mucosal atrophy and epithelial metaplasia. Recurrent abdominal pain (RAP) remain the most symptom associated to gastritis. Helicobacter pylori (H. pylori) infection is the most common cause of gastritis globally. Objective: This study objective to describe the incidence H.pylori-infection gastritis in children with RAP and the association between H.pylori-infection gastritis and children with RAP. Methods: During May 2020 to December 2020, all children age 2-18 years with RAP who fulfilled Apley's criteria or Rome IV were enrolled to this cross sectional study. Diagnosis gastritis based on endoscopy using Sydney classification and H.pylori infection with rapid urease test (RUT). Exclusion criteria included avoiding PPI, H2R antagonist and antibiotic two weeks before test. Results: Total 84 of 110 RAP subjects were diagnosed as gastritis and 66 positive RUT and 30 subjects as control. Most subjects 50 (76%) in age group more than 10 years old, boys 36 (54%) and girls 30(46%). Underweight in 2 subjects and 59(90%) were normal. There were significant association between RAP and H.pylori infection gastritis (X 2 , p<001). Conclusion: The incidence of H.pylori-infection gastritis among children with reccurrant abdominal pain was 60 % and there was a significant association between H.pylori-infection gastritis and children with RAP. Tobacco exposure might be related to increasing the incidence of H.pylori-infection gastritis among children with reccurrant abdominal