The Incidence of Birthmarks in the Neonate

Jacobs, Alvin H.; Walton, Robert G.

doi:10.1097/00006254-197702000-00014

Cited by 289 publications

(380 citation statements)

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“…Benton EC [5] has not reported a single case of neonatal dermatitis during 25 years of their study period. Some international studies have mainly focused on benign cutaneous lesions in newborns [6,7]. 34.75% neonates had skin manifestations during the study period, reported incidence is 27.6% to 31% [8,9].…”

Section: Discussionmentioning

confidence: 99%

Clinical spectrum of neonatal skin disorders at Hamdard University Hospital Karachi, Pakistan

Javed¹

2012

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Objective: To analyze the clinical spectrum of skin conditions in neonates at Hamdard university hospital. Study Design: Descriptive (Observational) cross sectional study. Methods: This study was conducted from January 2008 to December 2009. All neonates seen at Hamdard university hospital during this period were examined. Neonates with skin conditions with in 28 days of birth were registered on a predesigned questioner by the house officer these cases were confirmed by the pediatric consultant, followed by detail physical systemic examination and skin examination. Dermatologist was involved in the diagnosis of difficult cases. Results: Total numbers of new born seen during the year 2008-2009 were 1660, there were 65% males and 35% females, 1360 (81.92%) were above 2.5 Kg at birth, 18.08% were below 2.5 Kg. Numbers of neonates with skin lesions were 577 (34.75%). Neonates with skin infections were 25.12%, 15.59% had with nappy rash and 15.59 % had erythema toxicum neonatrum. Neonates with milia were 60 (10.39%) and with erythema were 27 (4.67%). Conclusion: Clinical spectrums of neonatal skin are different in this study as compared to other regional and international studies. StreszczenieCel: Analiza kliniczna spektrum chorób skóry u noworodków w szpitalu Uniiwersyteckim Hamdard. Projekt badania: Opisowy (obserwacyjny) przekrój badania. Metody: Badanie zostało przeprowadzone w okresie od stycznia 2008 do grudnia 2009 roku. W tym okresie zbadano wszystkie noworodki widziane w szpitalu uniwersyteckim Hamdard. Noworodki z chorobami skóry w 28 dni od urodzenia były zarejestrowane na gotowych kwestionariuszach przez lekarza rezydenta, następnie te przypadki zostały potwierdzone przez konsultanta dziecięcego, po szczegółowym systemowym badaniu fizykalnym i badaniu skóry. Dermatolog był zaangażowany w diagnostyce trudnych przypadków. Wyniki: Całkowita liczba noworodków obserwowana w latach 2008 -2009 wynosiła 1660, w tym 65% płci męskiej i 35% płci żeńskiej, 1360 dzieci (81,92%) było powyżej 2,5 kg po urodzeniu, 18,08% było poniżej 2,5 kg. Liczba noworodków z zmianami skórnymi wynosiła 577 (34,75%). Noworodków z zakażeniami skóry było 25,12%, 15,59% miało pieluszkowe zapalenie skóry a u 15,59% stwierdzono toksyczny rumień noworodków. Noworodków z prosakami było 60 (10,39%) a z rumieniem 27 (4,67%). Konkluzja: Kliniczne spektrum skóry noworodków w tym badaniu różni się w porównaniu do innych badań regionalnych i międzynarodowych.

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Section: Discussionmentioning

confidence: 99%

Clinical spectrum of neonatal skin disorders at Hamdard University Hospital Karachi, Pakistan

Javed¹

2012

Our Dermatol Online

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“…1 Capillary malformation (CM, 'port-wine stain'), (OMIM 163000) is a common vascular malformation, occurring in 0.3% of neonates. 2 CMs are flat cutaneous lesions ( Figure 1) that are typically located in the head and neck region, and change in colour from pink-topurple with age. 3 These lesions are usually obvious at birth and grow proportionally with the child.…”

Section: Introductionmentioning

confidence: 99%

Locus for susceptibility for familial capillary malformation (‘port-wine stain’) maps to 5q

et al. 2002

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Capillary malformation (CM; 'port-wine stain'), is a common vascular malformation affecting cutaneous capillary vessels in 0.3% of newborns. Increased incidence of lesions in first-degree relatives of these patients and several reported familial cases suggest that genetic factors may play a role in the pathogenesis of CM. We report the first genome-wide linkage analysis of familial CM. In the non-parametric linkage analysis, strong evidence of linkage (peak Z-score 6.72, P-value 0.000136) was obtained in an interval of 69 cM between markers D5S407 and D5S2098, corresponding to 5q11 -5q23. Parametric linkage analysis gave a maximum combined HLOD score of 4.84 (a-value 0.67) at marker D5S2044 on 5q15, and analysis using only the linked families, defined a smaller, statistically significant locus CMC1 of 23 cM (peak LOD score 7.22) between markers D5S1962 and D5S652 corresponding to 5q13 -5q15. Interesting candidate genes implicated in vascular and neural development, such as MEF2C, RASA1, and THBS4, are in this locus.

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“…1 Port-wine stain birthmarks are commonly found on the face and neck and, as such, may have serious psychological consequences. [2][3][4] Port-wine stain birthmarks do not involute over time (unlike hemangiomas) and, in fact, may hypertrophy in adulthood, resulting in increased disfigurement.…”

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confidence: 99%