The Incidence and Prevalence of Adult Primary Sjögren's Syndrome in New York County

Izmirly, Peter; Buyon, Jill P.; Wan, Isabella; Belmont, H. Michael; Sahl, Sara; Salmon, Jane E.; Askanase, Anca; Bathon, Joan M.; Geraldino‐Pardilla, Laura; Ali, Yousaf; Ginzler, Ellen M.; Putterman, Chaim; Gordon, Caroline; Helmick, Charles G.; Parton, Hilary

doi:10.1002/acr.23707

Cited by 41 publications

(45 citation statements)

References 32 publications

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“…Thus, patients with DLE in evolution towards SLE would be considered in this study as pDLE. There were several limitations regarding the development of the MLSP that have been previously acknowledged and could have accounted for under-ascertainment of prevalent and incident cases 1 9. Those included lack of participation from one quarter of rheumatologists and two hospitals in the catchment area, including the Veteran’s Administration Hospital, which may have specifically under-identified men diagnosed with pDLE.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, cases would have been missed if they lived in Manhattan but sought care in other boroughs or a neighbouring state. Additional limitations of the MLSP resulted from the tremendous differences across medical systems of case-finding sources and abstracting several years after the surveillance period 1 9. Additional limitations pertain to assigning race and ethnicity based on administrative and medical records which have been previously described 1 9…”

Section: Discussionmentioning

confidence: 99%

“…Details on the MLSP have been previously reported 1 9. In brief, medical records were reviewed under the health surveillance exemption to HIPAA privacy rules (45 CFR § 164.512(b)) and as authorised by New York City Charter Sections 556(c)(2) and (d)(2) with no potential cases being contacted for this project.…”

Section: Methodsmentioning

confidence: 99%

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Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program

et al. 2019

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ObjectiveEpidemiological data for primary discoid lupus erythematosus (pDLE) remain limited, particularly for racial/ethnic populations in the USA. The Manhattan Lupus Surveillance Program (MLSP) is a population-based retrospective registry of cases with SLE and related diseases including pDLE in Manhattan and was used to provide estimates of the prevalence and incidence of pDLE across major racial/ethnic populations.MethodsMLSP cases were identified from rheumatologists, hospitals and population databases. Two case definitions were used for pDLE: the primary case definition which was any physician diagnosis found in the chart and a secondary case definition which was limited to cases diagnosed by a rheumatologist and/or dermatologist. Rates among Manhattan residents were age-adjusted, and capture–recapture analyses were conducted to assess case under-ascertainment.ResultsBased on the primary definition, age-adjusted overall prevalence and incidence rates of pDLE among Manhattan residents were 6.5 and 0.8 per 100 000 person-years, which increased to 9.0 and 1.3 after capture–recapture adjustment. Prevalence and incidence rates were approximately two and six times higher, respectively, among women compared with men (p<0.0001). Higher prevalence was also found among non-Latino blacks (23.5) and Latinos (8.2) compared with non-Latino whites (1.8) and non-Latino Asians (0.6) (p<0.0001). Incidence was highest among non-Latino blacks (2.4) compared with all other racial/ethnic groups. Similar relationships were observed for the secondary case definition.ConclusionData from the MLSP provide epidemiological estimates for pDLE among the major racial/ethnic populations in the USA and reveal disparities in pDLE prevalence and incidence by sex and race/ethnicity among Manhattan residents.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program

et al. 2019

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“…Primary Sjögren's syndrome is one of the most common autoimmune disorders, having a prevalence between 0.1% and 4.6%. The incidence and prevalence rates were approximately 6 times higher among women than men [20].…”

Section: Discussionmentioning

confidence: 92%

The Utility of Major Salivary Gland Ultrasonographic Parameters in the Diagnosis of Sjögren Syndrome

Caraba

Babalic²,

Iurciuc

et al. 2019

Disease Markers

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Objective. To investigate ultrasonographically the salivary glands and to correlate ultrasonographic parameters with focus score, serum beta-2-microglobulin, and stimulated salivary flow rate. Material and Methods. 32 patients with primary Sjögren’s syndrome (pSS) and 32 healthy controls were enrolled in this case-control study, performed in the Department of Internal Medicine, Division of Rheumatology, “Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania. All the patients and controls were examined by salivary gland ultrasonography (B-mode, color and spectral Doppler, and sonoelastography), determining the following parameters: salivary gland ultrasonography (SGUS) score, resistive index (RI) of transverse facial artery, and shear wave velocity (SWV). Serum beta-2-microglobulin and stimulated saliva amount were determined in all the patients and controls. Minor salivary gland biopsy with focus score assessment was done in pSS patients. Results. Patients with pSS presented higher SGUS score and parotid and submandibular SWV and reduced RI of transverse facial artery than controls (p<0.0001). In pSS patients, statistically significant correlations were identified between assessed ultrasonographic parameters and focus score, serum beta-2-microglobulin, and respective stimulated saliva flow (p<0.0001). Conclusions. This study highlighted statistically significant correlations between salivary gland ultrasonographic parameters and focus score, serum beta-2-microglobulin, and stimulated saliva flow.

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“…The American College of Rheumatology (ACR) criteria allow 330 different combinations of symptoms and laboratory tests to affirm a diagnosis of SLE 11. Classification criteria are insensitive; they exclude patients who, despite disabling and treatable symptoms, fall below criteria thresholds and those who have overlapping or changing forms of SLE, whom practising physicians treat according to rules established for typical SLE 12–21…”

Section: Definitionsmentioning

confidence: 99%

SLE: reconciling heterogeneity

et al. 2019

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The Incidence and Prevalence of Adult Primary Sjögren's Syndrome in New York County

Cited by 41 publications

References 32 publications

Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program

Population-based prevalence and incidence estimates of primary discoid lupus erythematosus from the Manhattan Lupus Surveillance Program

The Utility of Major Salivary Gland Ultrasonographic Parameters in the Diagnosis of Sjögren Syndrome

SLE: reconciling heterogeneity

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